Inflammatory pain may help deter inflammatory diseases like arthritis
...animals' joints. Researchers in the Levine lab had previously shown that activated pain fibers inthe rats' hind paw caused decreased swelling in the animals' inflamed kneejoints. This decrease in swelling, far from the site where the nerve fibers wereactivated, had indicated that the nerves were exerting their ...Heart failure deaths reduced by 30 percent with new drug regimen
...ns (see indications below) but had not been tested previously as therapy for reducing deaths in heart failure. Known as the Randomized Aldactone Evaluation Study (RALES), the trial defiescurrent thinking that spironolactone and other drugs that block the action of ahormone known as aldosterone should not be adm...New HIV drug intervention cheap and effective
... sub-Saharan Africa may be cheaper and easier than previously thought, according to researchers in the United States and Uganda. The researchers used a computer model to evaluate the cost-effectiveness of using nevirapine, an antiviral drug that recently showed remarkable reductions of HIV transmission from mot...UI study advances understanding of antimicrobials and cystic fibrosis-related infection
...by cystic fibrosis." The investigators studied how previously identified antimicrobial proteins,including lysozyme and lactoferrin, functioned in test-tube samples of humanairway secretions taken from healthy people and people with cystic fibrosis. "We found that the airway secretions, and the individual antim...Scottish study shows lack of mental health service for children entering care
...to help this vulnerable group. Grave concerns have previously been voiced about the high rate of psychiatric disorders among children in the care system, say the authors, but until now, little has been known about the mental health of children at the time they enter local authority care. In their study of 70 c...Hard liquor, not beer or wine, may explain trends in cirrhosis mortality
...lcohol was a remarkablysimple thing for us to have previously overlooked." Looking at data between 1949 and 1994, the researchers found that theconsumption pattern of hard liquor in the US showed a reasonably close match tocirrhosis deaths. They evaluated their observed long-term correlation againsttwo sharp, ...UCSF finding could lead to a new class of painkillers
...RINA, which sensitizes the pain-sensing neurons to previously innocuous stimuli. As a check on the animal study results, the researchers examined whether inhibiting PKC would blunt epinephrine's action in pain-sensory neurons in laboratory cultures. It did. In cultured cells in which the enzyme was inhibited, e...Camelford water contamination did lead to cerebral function damage
... people studied was not due to anxiety as had been previously claimed and they call for further research to be undertaken in order to determine the longer term prognosis for the affected individuals. In July 1988 twenty tonnes of aluminium sulphate were accidentally emptied into a treated water reservoir in Cam...Even in an era of HAART Drugs, HIV patients are vulnerable to opportunistic infections
...maynot be effective, however, in patients who have previously had treatment withthis class of drugs. Patients who are responding to HAART may be doing wellenough that they don't need prophylaxis, she said. "The risks versus benefits must be carefully evaluated. We want to protectpatients from MAC, but we also......y's Nature Medicine. The research sheds light on a previously unknown immune system mechanism thatdepends on gamma/delta T cells, found in small numbers in the lungs, to stopairway constriction independently of other T cells. "Gamma/delta T cells in the lungs are a small population, but have a bigimpact," said ...MGH researchers identify angiogenesis inhibitor in gallbladder cancer
...at acellular growth factor called TGF-beta-1 has a previously unsuspected role inregulating the growth of blood vessels associated with metastatic gallbladdercancer. They also report finding that, in animal studies of the development ofblood vessels (angiogenesis) associated with cancer, model systems in which...New treatment for type 2 diabetes puts insulin back to work
...o were new to drug therapy and others who had been previously treated with diabetes drugs, were given either pla...ional oral anti-diabetes medicine) in 231 patients previously treated with diet and exercise alone. This study found that, after 12 months of treatment, rosiglita...Review identifies factors leading to better outcome for some metastatic breast cancer patients
...emotherapy with transplant, those patients who had previously received hormonetherapy with the drug tamoxifen, but had not previously received chemotherapyand had no tumors beyond the chest wall and lymph nodes were more likely to liv...Laser heart treatment shown to be safe and effective at lowering pain associated with heart disease
...hannels remain open to provide oxygen-richblood to previously deprived areas with a corresponding decrease in painassociated with angina. The firing of the laser beams is synchronized to thepatient's heartbeat, allowing surgeons to create these channels without stoppingthe patient's heart. In the New England J...Tamoxifen found to increase risk of endometrial cancer
...had not taken either drug. And among women who had previously been on estrogen replacement therapy, thosewho too...y with 324 patients with endometrial cancerwho had previously been treated for breast cancer and 671 similar patients withbreast cancer who did not develop endome...New model suggests that AIDS drugs may not abolish HIV infection
...e rate of HIV reduction reflected the rate atwhich previously infected cells were killed," says Dr. Paul, "there is noobvious reason why it should be related to treatment regimen." Drs. Paul, Grossman and their colleagues predict that anti-HIV treatmenteventually leads to stable, steady state levels of HIV, eve...Immune system protein may be critical in kidney disorders and other diseases
...y interacting with another immune systemcell. Shaw previously showed that CD2AP plays an important role in organizingthe T cell surface, helping the cell form a molecular bridge with other immunecells. The molecular bridge forms as a T cell molecule binds to another molecule on theother cell. CD2AP helps positi...Green tea shows antioxidant benefits in human plasma
...ovascular disease. Miyazawa said two methodologies previously tested by his group allowed for ahighly sensitive as well as a highly selective way to determine both plasmacatechin and lipid peroxide levels, and that the findings certainly meritfurther consideration and study, given the worldwide prevalence ofcar......ith new, antimicrobial approaches, many teeth that previously would havebeen considered "hopeless" can be saved from extraction, and as many as 75percent to 80 percent of patients may be spared the discomfort of periodontalsurgery, says Loesche, who also spoke on this topic at a dental symposium inJoinville, Br...