Therapeutic opportunities in neurodegenerative diseases
...inson's Disease,amyotrophic lateral sclerosis, and prion diseases. The use of inhibitors towardsprotein aggregation, secretase pathways and other targets, as well as a variety ofapproaches using stem cells, novel vaccines, gene therapy and modulation ofhormone levels will all be discussed....Crystallographers meet in Los Angeles
...new report on the three-dimensional structure of a prion protein, which may help explain the molecular basis for mad cow disease A talk on the chemical composition of the paint color Naples Yellow, sponsored in part by Christies auction house, which can help researchers identify and authenticate artwork fr...Science, engineering and technology news tips -- August 2001
...lepoy and colleagues built a mathematical model of prion growth. They set rules for how a few infectious pr...ons in their correctly folded form were added to a prion infection in progress. They found that if the dose were high enough, the foreign prions would block ...Vaccination delays onset of prion brain disease in mice
...a vaccine can delay symptoms in a natural model of prion disease in mice, according to the NYU researchers....pie in sheep. Humans can get a number of different prion diseases, including variant Creutzfeldt-Jakob disease (vCJD). The vaccine approach pr...Therapy for mice with prion disease could offer benefit to human beings with CJD
...nt which increased the survival time for mice with prion disease. These results could represent a new appro...ynucleotides) as a form of disease treatment after prion infection in mice. CpG oligodeoxynucleotides have previously been shown to stimulate the immune resp...Urgent need for more research into prevalence of CJD
...es were tested for lymphoreticular accumulation of prion protein, which is known to be a reliable marker of...results give an estimated detectable prevalence of prion protein accumulation of 120 per million. The margin of error for this figure is high and the authors...Action needed to prevent spread of vCJD
...mplications for tests (due to begin this year) for prion protein in tonsils collected from children and adu...whose tonsillar tissue tests positive for abnormal prion will develop vCJD, they are potentially at risk. The potential transmission of vCJD through blood m...Physicists study mad cow-type diseases
...models to study issues such as theincubation time, prion "strains" and treatment or detectionstrategies. Diseases such as BSE in cattle, Creutzfeld-Jakob disease in humansand chronic wasting disease in deer are all apparently caused byprions, misfolded versions of a normal brain protein. Similardiseases h...Blood transfusion poses CJD risk
...ansfusion as a possible route for infection by the prion protein responsible for variant Creutzfeldt-Jakob ... degree of tissue infectivity (using the misfolded prion protein as a marker) among macaques (monkeys native to south and southeast Asia) who were given tiss...UCSF scientists show prion shape affects nature of infection
... first time that a change in the folded shape of a prion protein changes its infectious properties -- inclu...ecies barriers." The research, based on studies of prion infectivity in yeast, solves one of the great puzzles about prions: If they are infectious proteins ...World's Alzheimer's disease experts to showcase latest research
...t and social-behavioral research Human and animal prion diseases, such as Creutzfeldt-Jakob and "Mad Cow" Alzheimer's Disease and the Alzheimer's Association: An estimated 4.5 million Americans now have Alzheimer's disease with millions more the Baby Boom generation about to enter the age of greates...New study raises questions about the number of people in the UK who could be incubating vCJD
...appendix and tonsil samples showed evidence of the prion protein associated with vCJD, but urge caution abo...ositive. Although the scientists are certain that prion proteins were present in three samples, only one showed a pattern of prion accumulation that resembl...Scientists raise concerns about second wave of 'mad cow' prion infection
... leukocyte reduction and value of integration with prion reduction for safer and more efficient blood proce...irector, Pall Medical: Results of new research on prion reduction by blood filtration technology: Scientific and Symposium presentations....Computer simulation shows how fibrils form
...such as Alzheimer's, Parkinson's and the so-called prion diseases like Mad Cow researchers at North Carolina State University decided to make movies. Dr. Carol Hall, Alcoa Professor of chemical engineering at NC State and Hung D. Nguyen, a graduate student in Hall's lab, used a computer simulation techn...New study shows how mad cow prions hitch a ride into intestine
...l of Medicine shows that the infectious version of prion proteins, the main culprits behind the human form .... Furthermore, the study finds that the infectious prion proteins, also known as prions, cross the normally stringent intestinal barrier by riding piggyback ...News tips from the Journal of Neuroscience
...f transmission of the infective agent, the scrapie prion protein (PrP Sc ). Mishra et al. were surprised to find PrP Sc associated with ferritin, a protein clearly abundant in muscle tissue associated with food....Infectious agent linked to mad cow disease found in organs other than the brain
... mice were infected with prions, the team detected prion accumulation in the inflamed organs. They conclude...inflammation. "The study suggests that the current prion risk-classification of farm animal organs may need to be reassessed in animals suffering from inflam...Test could improve detection of prion disease in humans
... refined in the future so it can be used to detect prion disease in living people and animals before the on...id Michael Nunn, Ph.D., NINDS program director for prion research. "It has been very difficult to generate diagnostic tests in this area and these results ar...Diagnosis of prions in patients should utilize novel strategy, team says
... involves detecting prions in brain sections using prion protein-specific antibodies -- may have led to an ...tudied, the traditional tests failed to detect the prion in a high proportion of cases. For example, in an experiment that focused on 18 brain regions from e...