People from large families may have greater risk of Alzheimer's
...e said. "The effects of impaired development could produce a brain that is normal, but functions less efficiently." Moceri said the negative effects of this less efficient brain would likely be marginal until they were aggravated by the aging process. "Families with five or more children were more like...Study: Productivity can be increased even as baby boomers retire
...be maintained and productivity can be increased to produce enough goods and services for society. Professor Robert L. Brown, using Canada as an example and noting similarities to U.S. conditions, says this can occur if people do not continue to retire at ever-earlier ages. Also, in a stable economy, this w...U-M health leaders offer an innovative framework for keeping academic medicine viable
...iences Research Corridor project, both intended to produce biomedical research results for the future of health care and Michigan's economy. "As we celebrate the 150th anniversary of medicine at Michigan, we are confident that the U-M is in a strong position to prepare the next generation of health care p......unex scientists used recombinant DNA technology to produce a soluble IL-4 receptor, a molecule the company names NUVANCE. When IL-4 binds with NUVANCE instead of cell-surface IL-4R, the effects of IL-4 may be blocked....Expert calls for common sense, science in national response to medicinal herbs
... protection that would cover development costs and produce profits as well as standardization that resulted in known strengths. "In comparison, many of the old botanicals were also effective, but they were discarded because of lack of patentability and subsequent assured profit margins," Tyler said. "Becaus...Novel approach may roust HIV from its hiding places
...or nelfinavir in the brain and testes of mice that produce P-glycoprotein, compared with mice that were genetically altered not to produce P-glycoprotein. LY increased the concentration of nelfinavir in brain tissue by 37-fold, and in the...New tools for early cancer detection
...normal growths. Using the Advanced Light Source to produce an intense beam focused on a tiny spot (typically 10 microns, the size of a human cell), Michael Martin of Lawrence Berkeley Lab (510-495-2231, MCMartin@lbl.gov ) and his colleagues can observe subtle molecular changes (such as DNA breaks) in living...'Smart scalpel' detects cancer cells in seconds
...er, make the cells part of the lasing process, and produce meaningful results. As it's turned out, we can do...r results The microcavity laser is far quicker to produce results than flow cell cytometers - the standard instrument used to determine the presence of cancer...New horizons, treatments in anticancer chemistry
...ne system to recognize tumor-specific antigens and produce antibodies that destroy them, vaccines could be used to keep tumors from recurring after conventional treatment. Targeted areas include prostate, breast, ovarian and colon cancer. Researchers will report on the latest advances, including some vaccine...Study links one human gene to multiple diseases of old age
... of tumors. Other genes stimulated by p21 produce proteins that cause or are associated with several... also stimulated by p21. Other p21-activated genes produce various proteins and enzymes that contribute to atherosclerosis, arthritis and amyloidosis. ...University of Rochester awarded patent for class of drugs known as cox-2 inhibitors
...chanisms by which steroids reduce inflammation and produce other effects in cells. "This patent recognizes the contributions of Dr. Young, an outstanding scientist who has devoted his career to understanding a problem that afflicts tens of millions of people," said Jay H. Stein, M.D., senior vice presiden...Purdue 'stealth compounds' attack cancer cells
...hat have fewer side effects and are less likely to produce drug resistance in patients being treated for cancer and certain viruses such as HIV, says Richard Borch, principal investigator of the study who is the Lilly Distinguished Professor of Medicinal Chemistry and Molecular Pharmacology at Purdue. "Pot......g its shield and is fed along its entire length to produce in one application a uniform electric field over the length of the gland. The frequency of operation is at the 915 MHz ISM band to permit sufficient penetration radially to heat the periurethral cells of the enlarged transitional zone. The windows in...Can the body trick the body into an autoimmune response to thwart HIV?
... strategy, Schiller's lab has persuaded monkeys to produce antibodies against CCR5, a protein on the surface of human cells that HIV latches on to. Other studies had suggested that blocking CCR5, a co-receptor for CD4, could be an effective strategy against HIV. People with two faulty CCR5 genes seem to be ...OHSU researchers discover new synapses in brain
... edition of the journal Nature. Oligodendrocytes produce myelin, a sheath that surrounds and insulates nerv...mmunication are in their immature stage and do not produce myelin. Previous work has shown that glutamate, the chemical used to transmit signals at these synap...Bexxar highly effective as first-line treatment for patients with non-Hodgkin's lymphoma
Study shows radioactive antibodies produce durable remissions of three years or more NEW ORLEANS - A radioactive antibody compound known as Bexxar produced tumor shrinkage in 97 percent of 76 previously untreated patients with advanced-stage, low-grade non-Hodgkins lymphoma (NHL) in a new s......cludes scaling up manufacturing of the antibody to produce quantities sufficient for human clinical trials, and conducting formal toxicity and pharmacokinetic studies. Ron Cohen, M.D., Acorda's president and CEO, states, "Acorda is proud of its collaboration with Dr. Rodriguez and Mayo Clinic. The identifi...Experimental drug reverses effects of Fabry disease in mice
...ation by inhibiting a key enzyme the cell needs to produce these molecules. We now have two compounds with high levels of inhibitory activity and no observed toxic side effects." According to the Journal of Clinical Investigation study, treatment with one of these compounds produced a highly significant red...Bad neighborhoods can cause depression
...thy, and danger, trouble, and crime are common may produce feelings of depression," said study author Catherine E. Ross, Ph.D., of Ohio State University in Columbus. Analyzing data from a survey of nearly 2,500 Illinois residents, Ross found that residents of disadvantaged neighborhoods -- characterized by a......at environmental cues associated with drug use can produce profound molecular changes in brain circuits linked to learning and decision-making as well circuits related to emotion," said Ann Kelley, UW Medical School professor of psychiatry. "The changes in cognitive regions may contribute significantly to th...