Discovery: Experiments Confirm Novel Eye Pigment Controls Circadian Rhythm
...at SAD patients have a defective gene that doesn't produce thepigment properly or simply suffer from a vitamin B-2 deficiency. Maybe we cantreat some patients with vitamin B-2." Second, industrial accidents such as those at Three Mile Island andChernobyl often occur at night. American industry has co...WFU And IntraVec To Develop Innovative Cancer And HIV Treatments
...is colleagues genetically modified normal cells to produce and secrete a toxin,or poison, that attacks and ki...t some people withcertain "defective" genes do not produce the chemokine that permits "docking" bythe HIV. Chen and his colleagues designed a novel ap...New Drug Boosts The Power Of Traditional Cancer Therapies, UF Animal Studies Show
... these effects by giving relatively low doses that produce no side effects in mice," Siemann said. Combretastatin A-4 prodrug, one of a new class of compounds that launch an indirect attack on tumors by interfering with their blood supply, is seen as a potentially effective therapy for solid tumors, which re...New Vaccine Being Tested In Prostate Cancer Patients
...r naturally and attached them to proteinswhichhelp produce an immune response. "Through chemistry, we were able to makesubstantial quantities of the material that allowed us to then do the testing,"addsKuduk. In mice, the Tn-protein complex was especially effective at triggeringantibody production. "It's a...Discarded Treatment For Heart Attacks May Yet Prove To Be A Life-Saver
...heart muscles can metabolize evenwithout oxygen to produce enough energy to help them maintain their membranesand the "pumps" that move sodium and potassium in and out of cells. It alsoreplaces potassium lost as a result of cell damage. And it may inhibit theinsulin resistance that occurs in heart attacks......HMI researchers have used x-ray crystallography to produce a three-dimensional picture of a key AIDS virus enzyme. The structure reveals details that clarify how HIV mutations render the retrovirus resistant to antiviral drugs such as AZT. Once HIV invades a human cell, reverse transcriptase (RT), one of th...U-M Researcher Addresses Changes In The Heart As It Ages
...slow by one beat a year and by age30, you begin to produce less of a protein that regulates how long each beatlasts, which means your heart must work harder on each beat to keep up itsnormal output. "Aging itself is not a disease and it is not unhealthy to age, but it does placesome limitations on the heart....Promising New Drug Uses Antibody Targeted Chemotherapy To Fight Leukemia
...ncer Research Center. "Also, the treatmentdid not produce some of the more common chemotherapy-induced side ...rtunistic infections). CMA-676 treatment does not produce theseeffects. As with all standard chemotherapy treatments, CMA-676 produces atemporary suppression......and then used the bacterialreproductive process to produce an identical recombinant amelogenin protein. This ... amelogenin protein, which the researchers can now produce inquantity, has since been shown to self-assemble to make nanosphere structuresidentical to those se...... of current and new infectious disease vaccines to produce effectiveimmune responses. Similarly, the ability of ISS-DNA to modulate the immuneresponse should enable the development of more effective therapies for chronicinfectious diseases and cancer. Dynavax's technology also provides opportunitiesto interv...Study Offers Hope For Immune Reconstitution After HIV Infection
...dversely affect the thymus, the gland continues to produce new Tcells after the infection is suppressed by intensive anti-HIV therapy. A reportof their findings is published in the Dec. 17, 1998, issue of Nature. "This is a very promising finding because it confirms that the thymus is activein adults and po...Children Of The Great Depression By Glen H. Elder, Jr.
... and group cohesion;adversity may also, of course, produce panic and demoralization. Glen Elder'sscrupulous and provocative account of the life course of people who werechildren during the Great Depression of 1929-1939, and came to maturity at theoutset of World War II, offers a convincing story of survival...Forecasting Killer Heat: UD Systems Predict Deadly Weather Worldwide
...d atmosphere within the tropicalPacific--routinely produce unhealthy heat levels, notes WMO representative TanjaCegnar, head of climatology at the Hydrometeorological Institute of Slovenia. "The current variability of climate, and the intensity of heat in large,urbanized areas, point to the need for this hea...Statistician Keeps Health Researchers Ahead Of The Curve
...ewform of data analysis called curve estimation to produce clearer pictures of howhealth changes over time. S...ected by HIV between 1984 and 1991. Wu was able to produce charts that will enable physicians to predict how quicklythese cells will decline. This information ...Study Finds Olestra Chips Don't Generate Gastrointestinal Woes
...hips,supported the new study. Other companies that produce and promote olestraproducts are Frito-Lay and Nabisco. Sandler, who does not own stock in the companies, agreed to conduct theresearch with the understanding that he would refuse to publish any conclusionshe did not support....... highlyeffective medications available that do not produce unwanted side effects suchas drowsiness....Interleukin-2 Boosts Cancer Vaccine Effectiveness In Mice
... immune responseagainst cancer cells, it could not produce antigen-activated T-lymphocytes fastenough to overcome large, well-established tumors, according to Mulé. "IL-2 gives the immune response a boost," Mulé said. "First, dendritic cellsfind and activate T-cells with the specific receptors...Insulin Resistance And Obesity Avoided In Genetically Modified Mice, As Reported In Science
... severe and early-onset form of thedisease) do not produce insulin at all and must give themselves regular insulininjections. People with type II diabetes do produce insulin but their bodies areresistant to its effects. Previous research has suggested that a...