Novel drug therapy tackles third 'pathway' causing congestive heart failure
... says. "Since in laboratory animals TNF alone can produce many of the symptoms ofcongestive heart failure, including dilation of the heart, a weakening of theheart's contraction force and a buildup of fluid in the lungs, it seems likelythat it would play a major role in heart failure." TNF is produced by th...Narcolepsy network issues national 'wake up' call
...S), which is characterized by "sleep attacks" that produce suddenand irresistible episodes of sleep. These episodes may last a few seconds tomore than an hour, sometimes occurring in the middle of conversation or whileperforming a task. Other symptoms of narcolepsy include: cataplexy - brief episodes of...Unexpected target may unlock the door to fighting sepsis
...he therapy preserved the capacityof neutrophils to produce hydrogen peroxide---a vital product in the ability...ook blood samples and stimulated theneutrophils to produce hydrogen peroxide. The neutrophils taken from ratstreated with antibody to C5a produced high levels ...Scientists use bacterial toxin to kill brain tumors
...d Pathobiologyat the U of T. "Some E. coli strains produce a toxin known as verotoxin. Ourearlier research has shown that, in the test tube, verotoxin kills certain braintumor cells very efficiently. We wanted to determine if this was also the casein a living animal." As part of her doctoral studies in Dr. L......ecrets behind this impressive ability. In order to produce a response in the olfactory system, molecules of aparticular substance must penetrate the nose. There they encounterolfactory receptors -- specialized proteins protruding from the surface of nervecells in the inner lining of the nose. When an odor mo...Transmitting infertility from father to son
...nks it's possible that men with AZFc deletions may produce normal amounts ofsperm during puberty and early adulthood, but less than normal amounts as theyage. "In that case, the physician might consider harvesting the boy's spermwhen he's younger and saving it until he's ready to start a family," he says. "...Weizmann Institute scientists develop a potential future treatment for myasthenia gravis
... for myasthenia gravis. Such fragments are easy to produce and are much less likely to trigger the productionof harmful antibodies than the entire receptor. Another major innovation of the study is that the receptor fragments were giventhrough the nose rather than injected. The nose drops protected the rats ...New, less invasive repair of major artery defect
...pecialistsbring to the procedure "have combined to produce optimal results." "This is clearly a procedure that requires extensive training to develop theskills necessary to do it safely and to do it with the best outcomes forpatients," he states. "At UNC, we've performed over 30 cases with successfulresults,...NYU researchers uncover the neurobiology of decision-making
... than to an inability to contract the muscles that produce amovement. If that turns out to be true, then we will have made an importantadvance in understanding just what goes wrong in these patients." Glimcher and Platt's Nature article is based on two experiments, both of whichmeasured the activity of dozen...New study will revolutionise treatment for Parkinson's disease
...isease occurs when nerve calls in the brain, which produce achemical messenger known as dopamine, die or are damaged. L-dopa is the current gold standard treatment for Parkinson's disease, but isknown to cause disabling side effects known as dyskinesias (twitching, noddingand jerking) when used over a long...Keep an eye on the weather if you take herbal antidepressants
... wort, reacts with visibleand ultraviolet light to produce free radicals. In laboratory experiments, JoanRoberts of Fordham University in New York and her colleagues showed that thisreaction can damage proteins in the eye that give the lens its transparency. "Ifthe proteins are damaged, they precipitate out ...Stress may increase susceptibility to infectious disease
... hormonesin the blood might produce an improvement in immunefunction. They also said that enough is known now to show thatcertain changes in lifestyle can increase a person's resistanceto some infectious diseases. Mo...New computer model supports the importance of annual mammograms
...model indicated that prompt annual screening would produce a 51percent reduction in breast cancer deaths. It also raised the possibility thateven more frequent screening could cut death rates even further - with twiceyearly screenings resulting in a death rate reduction as great as 80 percent. While the cur...Experimental peptides prevent diabetes and halt its progression
...hat some ofthese might prompt the immune system to produce Th2 cells. "We were trying to immunize NOD mice under certain conditions to induceGAD65-specific Th2 cells, which in turn would suppress the activity of Th1cells," Tisch says. The animals at the age studied were not overtly diabetic, "but wer...Immune system responds greater to uncontrollable stresses
... of the Dutch study. Uncontrollable stressors also produce high levels of cortisol, which suppressesimmune sy... efforts required to copewith high-level stressors produce only brief immune changes that appear to havelittle consequence for health. The researchers' findi...Combination immune therapy kills melanoma in mice
...diated, to kill them, andgenetically engineered to produce granulocyte/macrophage colony-stimulatingfactor (G...M-CSF). This compound, which the immune system can produce naturally,triggers scavenger cells known as macrophages to travel to a site of infectionand engulf i...For-profit hospital ownership means higher costs, Dartmouth-VA study finds
...they are more likely to respondto market forces to produce high quality services at lower costs," saysSilverman, also an instructor at DMS. "Previous work has focused on the costs of individual services. We haveexamined the impact of hospital ownership on the Medicare population as a wholeand found costs i...Cholesterol lowering in elderly reduces heart disease and strokes
...terol-lowering drugs,especially the statins, which produce the largest reduction in cholesterollevels. The report adds that cholesterol-lowering treatment works for bothwomen and men. The report's recommendations include: *Older Americans should have their total cholesterol tested once every...Study suggests potential new approach to glaucoma therapy
...tients with glaucoma." This enzyme -- NOS-2 -- can produce excessive amounts of nitric oxide, and Neufeldand colleagues regarded its presence as evidence that nitric oxide might beinvolved with the ganglion cell damage seen in glaucoma. To explore that idea,they set out to determine whether NOS-2 was causing...Friends don't influence the prejudices and stereotypes of adolescents
...ents' interactions with their friends, which would produce limited influence. Secondly, adolescents may influence each others' behaviors, but not their attitudes; there is often a discrepancy between attitudes and behavior." The final possible explanation for no effect being found, according to Dr. Fishbei...