Alcohol researchers confirm molecular culprit of alcohol-induced liver damage
...ding to Dr. Thurman, phagocytes, or Kupffer cells, produce TNF-alpha in theliver. These cells engulf foreign bodies, including endotoxin-producing bacteriathat enter the liver from the gastrointestinal tract. Increased gut permeabilityfrom alcohol consumption can increase endotoxin levels, triggering the rel...Getting your teeth into superplastic forming
... is then duplicated in an "investment" material to produce a completed diewhich is inserted into the superplastic forming press and heated to 900 degreesCelsius over a period of 90 minutes. A disk of titanium is then inserted intothe press, clamped above the die and 'blown' onto the die by Argon gas atpress...Extract from traditional Chinese herb enhances recovery in stressed cells
...edtoxic compounds. In this revved up state, cells produce an explosion of freeradicals which can cause permanent cellular damage. Antioxidants like vitamin C and E work by binding to free radicals andpreventing them from doing damage to the cells. But vitamins C and E are slowto penetrate the cell membra...... deliberately placed in locations where they could produce echoes thatresembled the sounds of spirits and other elements of ancient legends (4aAA4). Acoustical consultant Dave Lubman ( dlubman@ix.netcom.com ) will report thatancient Mayan builders may have mastered the acoustical design tricks needed toena...Scientists find protein in Epstein-Barr virus causes B cell lymphoma in laboratory mice
... bearing a mutationpreventing CD40 function cannot produce effective antibodies. Because CD40 and LMP1 have been shown to interact with the same cellularproteins, the researchers crossed the mice to learn whether LMP1 could partiallysubstitute for CD40 in the immune-deficient mice. That's exactly wha...... suppressing cell suicide would allow the virus to produce morecopies of itself and spread more effectively. "What we didn't expect was thatthis would cause the virus to become less of a killer, and to convert to apersistent infectious agent." A persistent infection is "heaven" for a virus, Lau explained. I...Results of NUVANCE phase I/II asthma trial presented
...unex scientists used recombinant DNA technology to produce a soluble IL-4 receptor, a molecule the company named NUVANCE. When IL-4 binds with NUVANCE (soluble IL-4 receptor) instead of cell-surface IL-4R, the effects of IL-4 may be blocked....UF researchers show magnetic stimulation may be a safe alternative to shock therapy
...r brains are stimulated with electrical current to produce seizures.Patients run risks from the anesthesia, and the treatment often produces cognitive problems, such as memory loss, that maylast for months. "Because there are so many side effects to stimulating the brain withelectroconvulsive therapy, we wa...Discarded thymus tissue provides life for infants with DiGeorge Syndrome
...nd B cells, which arespecialized immune cells that produce antibodies to signal the presence of aninfection, ...t to the thymus after stemcells in the bone marrow produce them. "These immature T cells go to the thymusto get trained," she says. "It's just like going to sc...Yale cancer center to test cervical cancer prevention drug: NCI grant funds research
...Cancer-related viruses such as Epstein Barr or HPV produce oncoproteins, whichkick off the process of reproduction. By inhibiting the proteins, the tumorcells stop replicating. HPV depends on the E2 protein to keep itself going, soindole 3 carbinol was developed specifically to disable that protein so cruci......w is thawed and re-infused back intothe patient to produce a cancer-free immune system. Reynolds' group at CHLAcleansed the bone marrow for all the transplant recipients in this study. In a second phase of the trial, a subsequent therapy of high doses of 13-cisretinoic acid was given to a randomized selectio...Changing approaches to treating gum disease
...of anaerobic bacteria on the teeth. These bacteria produce toxins that can damage the gums. For some patients, thebest approach may be to combine the traditional scraping and planing withshort-term use of systemic antibiotics such as metronidazole or doxycycline,which are effective against anaerobic bacteri...Publicity about bowel cancer screening leads to reassurance not alarm
...eening Publicity about cancer screening does not produce widespread alarm say researchers from the Imperial Cancer Research Fund in this weeks BMJ. In a randomised controlled trial of nearly 3,000 (2,961) adults aged 55-64 years, Professor Jane Wardle et al found that patients who received information abo...New light on the role of microbial pathogens in atherosclerosis
...rol. Between 50 and 60% of the humanpopulation can produce high levels of this cytokine, while 40 to 50% produceintermediate levels and 5 to 10% can only synthesize small amounts. The Inserm team worked on a mouse strain deficient in IL-10. The animals wereraised in cages with filtered air (protecting them ...Duke team seeks novel vaccine strategy for HIV
...n't penetrate. "With this in mind, the trick is to produce an immune response that constantlyputs pressure on the virus and never lets it gain strength," Montefiori said. In order for an antibody to kill, or neutralize a virus, it must first "latch"onto the invader. What makes HIV such a formidable fo...Hopkins gene therapy trial is first to activate entire human immune system against prostate cancer
...ues. "The ability to activate the immune system to produce antibodies against cancerprovides critical new fundamental information that will broaden the potential ofthese gene therapy trials," Simons notes. Based on the research reported inCancer Research, Simons, Nelson, and team currently are conducting la...Lack of sleep alters hormones, metabolism
... suggesting that even eight hours of sleep doesnot produce the fully rested state. Young adults may function best after morethan eight hours of rest each night. "While the primary function of sleep may very well be cerebral restoration,"note the authors, "our findings indicate that sleep loss also has conse...Yale and state researchers develop improved test for new tick disease
.... But unlike Lyme disease, Ehrlichia equidoes not produce a bull's eye rash, which makes it more difficult to diagnose,said Dr. IJdo, a physician-scientist. Another problem hampering diagnosis is that testing for ehrlichiosis istime-consuming, costly, and is only performed in specialized researchlab...Jefferson researchers show melatonin's potential benefits in preventing Parkinson's damage
...ative stress to the cells.Various cellular insults produce oxygen free-radicals, resulting in cell death.The brain's dopamine neurons are particularly vulnerable. Melatonin, a hormone produced by the brain and which is marketed as ananti-aging agent commercially, is the body's most potent antioxidan......ugs such as cocaine and ecstasy have been found to produce long-lasting and possibly permanent cognitive defi... abuse in early adolescence or early adulthood can produce profound cognitive deficits that may persist for a couple of years or more after amphetamine use has...