Report in Circulation urges a closer look at cardiotoxicity of cancer drug trastuzumab (Herceptin)
...itional information is available. "As cited in FDA product labeling, a substantial number of women treated with trastuzumab developed congestive heart failure; seven percent when receiving the drug alone in an open label study, and 28 percent when treated with a combination of trastuzumab, anthracycline and ...Product design and drug development breakthroughs help the environment
...ntists for environmentally conscious innovation in product design and drug development. The awards, sponsored... original production process, while increasing the product yield by more than 25 percent. U Using water, not hazardous solvents to spray on plastic coating (Pi...Pacific Northwest National Laboratory wins three R&D 100 awards
...an cause irregular cuts and generate truckloads of product that doesn't meet quality specifications. Processing plants incur costs to re-sort the product and have the waste shipped away for use as animal feed. Human inspectors can take upward of an ...Living in the pharmaceutical century
...chnology that made them possible. The history is a product of the joint efforts of four ACS publications: Chemical & Engineering News, the Society's newsweekly; the magazines Modern Drug Discovery and Today's Chemist at Work; and the research journal Analytical Chemistry. It will be distributed to all 161,00...Jefferson scientists hope to perfect gene therapy without viruses
...erted in exactly the right place and expressed its product - in this case, an antibiotic-resistant gene." Their results appear August 22 in the journal Gene. The technique has several advantages. "It avoids using viruses that cause immune reactions, it puts the gene in a precise, known location as opposed ...Testosterone skin patch improves sexual functioning in surgically menopausal women
...testosterone patch and is currently developing the product in collaboration with Watson Laboratories. "We know that women who have gone through menopause after surgical removal of their ovaries have decreased testosterone levels," says Jan Shifren, MD, of the MGH Vincent Memorial Obstetrics and Gyneco......rug Administration for review. The Zithromax® product label currently includes a 5-day, once daily dosing schedule that may make finishing medication easier than with conventional 10-day antibiotic regimens. This randomized, double-blind trial conducted at nine U.S. centers evaluated 350 children betwee...NIH awards grant to MetaPhore Pharmaceuticals to study novel pain treatments
...molecules into hydrogen peroxide and oxygen. This product of SOD's catalytic action also has potential benefits that complement those of free radical removal. Hydrogen peroxide has been shown to be critical to the functioning of white blood cells in killing foreign bacteria. "SOD mimetics have major medic...Hutchinson Center receives $1.2 million from National Science Foundation to study plant genetics
...be used for more detailed analysis. The entire PCR product is then heated and cooled, which causes the zipperlike DNA strands to separate and then randomly come back together. Any imperfect pairings indicate an area of genetic disruption, which can be analyzed further to pinpoint the exact genetic mutation. ...Attachment helps young children inhale asthma medications, UF researcher says
... therefore, there is no reason to use an albuterol product containing benzalkonium. Hendeles says his efforts to teach physicians and patients about the alternatives stem from wanting to make the care of an asthmatic child as easy for parents as possible and more cost-effective for the health-care system....ARICEPT better tolerated than Exelon in patients with mild to moderate Alzheimers disease
... Study patients treated according to approved product labeling NEW YORK, SEPTEMBER 27, 2000 - Resu...ks. Patients were dosed according to the approved product labeling for each medication. Patients in the ARICEPT study arm received 5 mg once daily for 4 we......l data on saliva that we have generated during our product development program, said Linda H. Masterson, Pres...combined in the LifePoint Test System enable broad product expansion into additional markets including therapeutic drug monitoring, rapid diagnostic testing, a...FDA awards grant to metaphore pharmaceuticals to study septic shock in humans
...molecules into hydrogen peroxide and oxygen. This product of SODs catalytic action also has potential benefits that complement those of free radical removal. Hydrogen peroxide has been shown to be critical to the functioning of white blood cells in killing foreign bacteria. SOD mimetics have major medic...... Arkansas Clinic on Friday, November 10. Maret's product development focuses on MARstem, an analog of the angiotensin family of novel small peptides to treat a variety of conditions that could benefit from an increase in the formation and release of stem cells. In addition to the adjuvant breast cancer st...European commission grants "orphan" status for new acute myeloid leukaemia treatment
...ukaemic cells. This compound represents the first product from Wyeth's promising oncology pipeline." As a de...tisfactory method of treatment exists or where the product will be of significant benefit. Orphan medicinal products do not automatically qualify for approval ...GPs prescribe significant numbers of "off label" drugs to children
...rugs to children that are outside the terms of the product license - "off label" - finds research in the Arch...bed for licensed medicines within the terms of the product licence. Less than half a per cent were for unlicensed medicines, but one in 10 were for off label l...Common hearing test for newborns may be wrong up to a third of the time
... study directly compared the results of distortion product otoacoustic emission (DPOAE) tests, analyzed using four different "pass" criteria, with those from auditory brain stem response (ABR) tests. The four different criteria were used because there are currently no universally accepted standards for a "pa...Product Quality Research Institutes (PQRI)
...d reporting requirements without compromising drug product quality. The institutes recommendations based on this research are expected to speed new drug approvals and reduce the industry's cost for pharmaceutical development. For additional information about PQRI, visit www.pqri.org. About AAPS PQRI is ...FDA, drug industry and scholars find success in effort to tackle regulatory issues
...sting policies while ensuring the highest level of product quality. PQRI is administratively managed by the American Association of Pharmaceutical Scientists (AAPS). In its first year, PQRI identified seven "working groups" to address the following regulatory issues: blend uniformity, manufacturing changes...Novartis receives FDA approval for Starlix, a new treatment for type 2 diabetes
... Yamanouchi and Hoechst Marion Roussel market the product in Japan under brand names Starsis or Fastic. Novartis licenses Starlix from Ajinomoto Co. Inc., Japan, and has a co-marketing and co-promotion agreement with Merck KgaA within Europe, and in certain African, Southeast Asian and Latin American count...