Study could lead to exercise-mimicking drug
...ulin-dependent protein kinase (CaMK) that controls production of mitochondria in mammalian muscle tissue. Mitoch...rs a signaling pathway that controls mitochondrial production in mouse cells, so that the muscles of sedentary mice assumed the characteristics of muscles of anim...Mice lacking fat-making enzyme are leaner, more sensitive to leptin and insulin
...nimals, DGAT is essential for the last step in the production of triglycerides, the major component of fat. Mice that lack one of the DGAT enzymes, DGAT1, are leaner than mice with normal amounts of DGAT1and twice as activedespite their high-fat diets. Put simply, without DGAT1, the mice werent able to become o...A combination of targeted therapies may be needed to keep prostate cancer at bay
...ce to standard treatment with drugs that block the production of testosterone.) The drug was then given to the two groups of mice orally (with a dropper) five times a week for three weeks and compared to a control group of mice that received no drug. The investigators found that tumor growth was inhibited by ...Buck Institute researcher identifies new drug targets for Alzheimers disease
...ually provide significant relief by inhibiting the production of the toxicpeptide that causes the harm in the fi...find drug inhibitors for these targets that reduce production of beta-amyloid, it is possible that these drugs may provide new therapeutics for treating Alzheimer...Statin drugs may lower risk of Alzheimers
...sity lipoprotein (LDL) cholesterol by blocking the production of a liver enzyme used by the body to make cholesterol. In this study, cholesterol-lowering drugs other than statins were not associated with a reduced risk of Alzheimers. There was also no difference between the use of natural and synthetic statins....Retinal cell implantation shows promise and improvement in advanced Parkinsons disease patients
...ed retinal cells serve as a new source of dopamine production in these patients. "This is the first human intracerebral retinal cell implantation study in the world and we are encouraged by the results so far," Dr. Watts reports. "Weve been following these six participants for over a year, and weve found the...Fetal cell transplants show long-term benefit for Parkinson's
...s into the brain. The progressive loss of dopamine production in the brain triggers the symptoms of Parkinsons.The transplants duplicated the results that patients had been receiving from the drug levodopa, themain drug for Parkinsons, prior to the transplant. The results were directly proportionate to the resu...... TxA2 formation to go unchecked by suppressing the production of PGI2. We wished to investigate the likely impor...en their opposing actions, he speculated that PGI2 production is stimulated as a response to platelet interactions with the vessel wall, to limit the harmful effe...American Thoracic Society Journal news tips for April (second issue)
... organism that, when entering the body, causes the production of an antibody to neutralize, destroy, or weaken it. Based on a skin prick test, the mildly allergic asthmatic students received a graded inhaled antigen challenge of either ragweed, cat dander, or house dust mitesubstances that would cause an immed...Applied Biosystems introduces next generation production level DNA analysis systems
...systems 3730xl DNA Analyzer. These next generation production scale systems are expected to improve data quality...he human, mouse and other important genomes. These production level systems could further accelerate discovery and significantly expand the sequencing market by m...Special cell prevents diabetes in mouse model, report University of Pittsburgh researchers
...l the bone marrow dendritic cell into blocking the production of the IL-12 cytokine, a hormone-like substance th...cate with each other. Because the B220+DC inhibits production of IL-12, a cytokine that normally signals T cell proliferation, the researchers wanted the bone mar...Heart health should be the front line of diabetes care
...s type 2 diabetes, which results from insufficient production of insulin, poor response to insulin (insulin resistance) or both. People with type 2 diabetes often have other risk factors for CVD too, such as high cholesterol and obesity. Type 2 diabetes is usually brought on by obesity, but susceptibility to ...Statin drugs may increase risk of peripheral neuropathy
...sity lipoprotein (LDL) cholesterol by blocking the production of a liver enzyme used by the body to make cholesterol....NIAID teams with Wyeth on HIV/AIDS vaccine
...efine several versions of the vaccine and scale-up production capacity. Eventually, the experimental vaccine will be tested in people through NIAIDs HIV Vaccine Trials Network. NIAID launched the HVDDT program in 2000 with four contracts to public-private research teams totaling $70 million over 5 years. Li...Mayo Clinic study links gene to heart disease marker
...on between common variations in IL-1 genes and the production of CRP and other inflammatory proteins by the live...in reaction of inflammatory proteins that leads to production of CRP. "By understanding the genetic underpinnings of cardiovascular disease, physicians may in the...Cancer drug proves effective in treating sickle cell disease
..."Like hydroxyurea, decitabine works by turning the production of fetal hemoglobin back on," DeSimone explained. ...the sickling of the cell. Increasing the patient's production of fetal hemoglobin results in a decrease in the severity of sickle cell symptoms. Patients have few...First clinical data presented on latest technological advance in haemophilia a therapy
... of human- or animal-derived components during the production process and final formulation. All currently avail... or animal-derived proteins at some point in their production processes or final product formulations. To date, more than 5 billion units of Recombinate rAHF hav...High blood pressure drug eases vessel stiffness, lowers systolic pressures
... inhibitor, the single-molecule omapatrilat blocks production of the potent vasoconstrictor hormone, angiotensin II. It also blocks the breakdown of a family of hormones that cause vesselsespecially large arteriesto dilate and become less stiff, Mitchell explains.The researchers used pulse pressure (the differ...Studies yield key insights in preventing destruction of insulin-producing cells
...eventing type 1 diabetes and of preserving insulin production in people newly diagnosed with the disease. The s...he drug delayed the progressive decline in insulin production typically seen in type 1 diabetes. One year after treatment with anti-CD3 mAb, the treated patient...Type 1 diabetes safely arrested with short-term use of new drug
...is more chronic in nature." Preserving insulin production is a very important finding of this trial since patients taking the new drug would not be entirely dependent on exogenous insulin for metabolic control, says Columbias Kevan Herold. People with diabetes who make some insulin have a much easier time i...