Investigational drug may provide new option for preventing transplant organ rejection
...one of the most promising safety and effectiveness profiles of any new immunosuppressive agent tested in the 20 years since the introduction of cyclosporine," said Christian Larsen, MD, DPhil, director of the Emory Transplant Center and a co-investigator. "Currently available anti-rejection drugs like cyclosp...Research targets biologic profile of obesity
...or RNA extraction. Upon analysis, gene expression profiles of obese patients were compared to the lean control samples, with and without gender separation. Genes with statistically significant up- or down-regulation of more than two-fold were considered for further inspection. Of 120 patients enrolled, gen...Increased risk of cardiovascular disease shown in PCOS patients
...ifferent metabolic or inflammatory CVD risk factor profiles when compared with controls. "While past studies have shown that menstrual irregularity, which is a sign of PCOS, may be a metabolic marker for CVD, solid evidence linking PCOS to CVD disease has been difficult to acquire because of the lack of a ...Cancer gene therapy news backgrounder: New ideas fuel next generation gene therapy research
...other treatments until the time comes when genetic profiles can be developed of each individual person's unique cancer. Then, therapies tailored exclusively to the patient can be developed, and gene therapy may ascend, says Jack Roth, M.D., an M. D. Anderson researcher who is nationally known for his pioneeri...CAD system shows promise as adjunct to breast MRI
...wed no significant differences between enhancement profiles of the benign versus malignant lesions," she said. "It is important to note again that this is a very small sample, and further research needs to be done," she said. Dr. Chen will present the study on May 4 at the American Roentgen Ray Society Annual...Pfizer's VFEND (R) as effective in treating Candidemia as two-drug standard of care, study shows
...hotericin B therapy was 4 days. The adverse event profiles were comparable for both treatment groups. However, more renal events were reported in the amphotericin B/fluconazole arm. Discovered and developed by Pfizer, VFEND is indicated for the treatment of serious fungal infections. In the U...Combination therapy w/ ACTOS (pioglitazone HCI) shown to improve components of diabetic dyslipidemia
...dications, on the lipid subspecies and subparticle profiles of patients with diabetic dyslipidemia when administered in conjunction with other diabetes therapies. Three randomized, double-blind, multi-center trials studied the effect of ACTOS 30 mg or 45 mg plus either a sulfonylurea, metformin or insulin on ...Low-dose transdermal estrogen viable short-term treatment for menopausal women
...ses and delivery systems may exhibit better safety profiles than CEE/MPA formulations, with no loss of efficacy," Dr. Minkin noted. Transdermal, unlike oral, HT delivery bypasses the liver, permitting the use of estrogen doses that are substantially less than in pills, thereby reducing the risk of certain a...CNS cancers and other diseases: Using proteomics to identify unique protein 'fingerprints'
... to test the diagnostic sensitivity of the protein profiles for larger scale clinical use....SSX, a new family of cancer vaccine targets
...nical trial, which will assess the safety and dose profiles of an SSX-2 peptide-based vaccine, is scheduled to begin this year at the CVC Clinical Trials Center in Zrich, Switzerland....Concussion causes emotional disturbances, say researchers
...A comparison of pre- and post-concussion emotional profiles of athletes to the emotional profiles of a healthy functioning comparison group could also highlight important emotional changes that resu...Preschoolers lead growth of antidepressant use, study reveals
...he April issue of Psychiatric Services. The study profiles trends of prescription antidepressant use in children and adolescents using prescription claim information from a random, nationwide sample. The study by Express Scripts examined antidepressant use among approximately two million commercially-i...Nanotech imaging, molecular fingerprints and signatures hold promise for cancer
...olecules. By comparing the albumin-binding protein profiles from 115 ovarian cancer patients with 127 healthy women, Mehta and colleagues discovered clusters of proteins from cancer patients that differed radically from the protein profile found in healthy women. The results were extremely sensitive and speci...Mount Sinai to offer NearVision CK
...were reported, giving CK one of the highest safety profiles among refractive procedures. CK uses leading-edge radiofrequency energy, instead of a laser or scalpel, to restore near vision without cutting or removing corneal tissue. In a three-minute procedure using topical (eye drop) anesthesia, CK uses a...Blood protein may be important predictor of future cardiovascular attack
...w adding C-reactive protein (CRP) to patient lipid profiles because of past study findings that high levels of CRP are predictive of heart attack and other cardiovascular events such as stroke," said B. Delia Johnson, Ph.D., epidemiology faculty research associate at the University of Pittsburgh's Graduate Sc...Stroke news tips for Friday, Feb. 6, 2004
...morrhagic stroke and healthy individuals. Genetic profiles were studied in 343 patients with ischemic strokes, 157 with hemorrhagic strokes, and 108 healthy controls. It turns out that one gene type with the SNP variant, the AA allele, was less prevalent than the GG allele among stroke patients than the hea...Novel technique may help detect certain head and neck cancers
...s. The researchers discovered several protein profiles that were present more commonly in patients with HNSCC than in healthy smokers or control patients. Using these protein patterns to develop a classification system, the researchers were able to distinguish between patients with HNSCC and normal and ...Study expands understanding of alcoholic memory disorder
...n these disorders is the same, while their overall profiles are different." The amnesia of alcoholic Korsakoff's syndrome was long believed to be rooted in the thalamus (relay center for impulses) and other deep structures of the brain. The Korsakoff's patients in the study had twice the hippocampal damage pr...Dependent older patients may cost hospitals more
...ese figures to take into account the difference in profiles of dependent and independent patients, they still found that dependent patients cost the hospital 23 percent more than independent patients. The team found that most of the differences in cost could be attributed to the fact that dependent patients h...After bypass surgery, women have worse quality of life than men
...en, finish worse than men, and have worse recovery profiles than men," she concluded. While there was a significant difference in the quality-of-life measurements, the impairments to cognitive function attributable to the surgery were similar between men and women. Since the differences between the genders ca...