OHSU researchers uncover genes involved in early stages of Alzheimer's disease
...re involved in mitochondrial energy metabolism and programmed cell death. "We studied gene expression levels at three distinct stages of disease progression in the genetically-altered mice relative to age-matched wild-type normal mice," explained Reddy. "We conducted gene expression analysis long before (2 mo...Temperature and humidity can affect LASIK surgery results
...al data should play a role in how the equipment is programmed to further refine the visual outcome," said Walter. He has developed a formula for programming the equipment at Wake Forest, and has already seen improved results. "Our study doesn't mean that consumers should avoid LASIK surgery during the summer," ...Jefferson scientists find how HIV causes dementia
...ound that two "well described" pathways leading to programmed cell death called the intrinsic and extrinsic systems were activated by viral proteins. "We feel that it's mainly the virus and viral proteins causing the neuronal cell death, and now may know the precise pathways involved," Dr. Pomerantz says. "Now ...Discovery sheds light on how cancer cells grow and divide
...r the cell, and as such is involved in the natural programmed cell death called apoptosis. In yet another role, the centrosome is important in setting up the two poles of the cell during mitosis, when cells segregate their chromosomal material and divide. Both these functions, when disrupted, can cause disease....Alcohol use and victimization among college women
...gression, what have you, is not something that's programmed into people. The perpetrator has a choice; they don't have to attack or assault. The issue is not the woman's drinking, although obviously the woman's drinking increases the risk, the issue is the perpetrator's choice to engage in a particular be...Cell research uncovers intriguing clues to 'Trojan horse' gene in HIV infection
...e protecting the infected cells from apoptosis, or programmed cell death. Dr. Finkel and colleagues used a genetic-based technique called suppressive subtractive hybridization to identify gene products involved in maintaining cell survival, despite HIVinfection. By comparing dying T cells with surviving T cell...Existing therapies applied to new use in broader spectrum of cancer care
...ng to up-regulation of genes causing apoptosis--or programmed cell death. Lindner and Bauer documented how the elevated levels of nitric oxide in the tumor cells inhibit a molecular pathway that normally promotes cell survival. By hampering the activity of the NFkB pathway, elevated nitric oxide pro...Advances in prevention and treatment research hold promise for 'pipeline'
...progesterone receptor antagonist appears to induce programmed cell death, or apoptosis." In comparison to other therapeutics that target steroid receptors to reduce tumor growth, such as the anti-estrogen tamoxifen, the agent studied by Hoffmann and his colleagues is unique because it does not just stop the c...Optical glucose sensor holds promise for diabetics and intensive care patients
...ucose monitor connected to an insulin pump that is programmed to deliver appropriate doses of insulin to maintain healthy blood glucose levels. "That is the holy grail that many people have been pursuing. It won't cure diabetes, but it would make management of the disease a lot easier," Singaram said. Singaram...Lupus discovery may pave way to better-designed COX-2 inhibitors
... discovered how autoimmune lupus T cells stave off programmed cell death and drive production of autoantibodies directed against the body's own DNA. Syamal Datta, M.D., and colleagues found that lupus T cells increase production of an enzyme called cyclooxygenase 2 (COX-2), which helps trigger inflammation, ...New technology facilitates adherence for patients
...n be delivered with inhalers, some of which can be programmed to deliver specific doses. "The ultimate goal," Dr. Langer concluded, "is to administer drugs at the right time, at the right dose anywhere in the body with specificity and efficiency. This will help all patients take their medications when they ne...Sepsis drug also protects brain cells
...ect against a variety of causes of "apoptosis," or programmed cell death, one of the major ways we all lose brain cells. Preventing neurons from killing themselves committing apoptosis when they shouldn't is a broad goal of researchers. Apoptosis often happens when cells detect danger and go into a state ...U.S. push for diesel poses risk to public health, scientists say
...ontrols such as traps and filters. The researchers programmed data from the extensive U.S. National Emission Inventory into their model. The inventory contains emissions from hundreds of thousands of sources including 1,700 types of vehicle sources, of which 870 types are gasoline. The researchers validated the...Researchers create lung cancer 'cluster bombs'
... to." The idea is that the nanoparticles can be programmed to escape immune system surveillance like a Trojan Horse, and carry designer drugs that target cancer cells while leaving healthy cells alone. "This drug and this delivery system have a lot of potential--there are a lot of different things we can ...A pair of discoveries helps unravel complex genetics of inflammatory bowel disease
...f the foremost regulators of the immune system and programmed cell death. The results are reported in the January 1, 2004 issue of the journal Human Molecular Genetics. "Our greatest hope is that by identifying the gene abnormalities associated with inflammatory bowel disease (IBD), we'll be able to figure out ...Drug prolongs lives of chronic lymphocytic leukemia patients
...eve rituximab kills malignant CLL cells by causing programmed cell death, or apoptosis. This randomized phase 2 study included 104 previously untreated CLL patients. The outcomes of these patients were compared to those of 179 similar patients who received fludarabine alone as part of an earlier randomi...Most hospitals don't use latest ordering technology
PORTLAND, Ore. -- Computers programmed to screen out errors and standardize physicians' orders for prescriptions, tests and other care have been a source of hope in reducing medical errors and improving patient safety. The problem is that most hospitals aren't using this technology, known...Hearing problems may be programmed at birth
Hearing loss in adulthood may be programmed at birth, and short people may be particularly susceptible, say researchers from Sweden in this week's BMJ. Their conclusions are based on the theory (known as the thrifty phenotype hypothesis) that events before birth, such as malnutrition or exposu...Epstein-Barr virus contributes to Burkitt's lymphoma
...die. "In effect, EBNA-1 rescues B cells from their programmed death, and allows the cells to continue to prolife...patients," Sugden says. "Such therapy would induce programmed cell death in Burkitt's lymphoma." It's reasonable to expect, he says, that a small molecule could ...Brain signals from the paralyzed or injured captured by computer
...ts with the two-way radio link and can be remotely programmed to detect and sort the neural signals received by the prosthetic device. The device is designed to be placed under the skin on the skull and connected to recording electrodes in the cortex. These electrodes amplify and transmit the recorded signals f...