New compounds effective against Alzheimer's disease onset and progression
...for future drug development because they provide a proof of concept that targeting neuroinflammation with aminopyridazines is a viable Alzheimer's disease drug discovery approach that has the potential to modulate disease onset and progression, Van Eldik said. Deposition of the beta-amyloid plaques and ne...Rehabilitation professionals in nationwide survey cite barriers to assistive technology transfer
...G. Collins, Clarkson University President. "We're proof positive that academia, healthcare providers and industry can join forces to facilitate effective assistive technology transfer and allow consumers to more readily tap into the reservoir of available technology options." About the Survey The Barrie...Engineered stem cells can home in on tumors and deliver drug payload in mice
...the Journal of the National Cancer Institute, is a proof of principle, conducted in mice, that shows this k... beta therapy in this study is less important than proof that the MSC strategy works. "The most important discovery here is that these cells are indeed homin...Radiotherapy + cetuximab significantly improve disease control and survival in head and neck cancer
...one year and from 48% - 56% at two years. "This is proof that drugs coming from the laboratory can be used to cure more patients", said Dr. Giralt. Overall toxicity resulting from the combined treatment was dominated by recognised side effects of high dose head and neck irradiation e.g. mucositis (inflamma...Human spinal cord cells help rats with Lou Gehrig's disease
... and behavioral sciences at Hopkins. "Our study is proof of principle, that neuronal stem cells do have potential in conditions caused by separation within the nervous system, whether by disease or injury." The next step, he says, is to see whether a more aggressive treatment approach might further improv...The 23rd Congress of the European Society for Therapeutic Radiology and Oncology (ESTRO)
...r survival rate after 3 years. With this trial the proof of principle is established and demonstrates that the use of "smart drugs" will lead to improvements in cure rates. The design of such smart drugs is based upon an investigation of mechanisms leading to uncontrolled cell growth in the cancer process....MRI can measure early benefits of cholesterol-lowering drugs and plaque reduction
...of plaque reduction. "The direct correlation was proof that, indeed, the early benefits of statin therapy resulted from its lipid-lowering properties," said Lima. According to the latest statistics from the American Heart Association, in 2001, there were more than 72,100 deaths directly related to athero...Switch of a gene turns cancer cells healthy in mice, Stanford scientists find
...ells and produced liver proteins. These cells were proof that turning off the Myc gene alters the cell's fate rather than killing it outright. The hurdle now is finding drugs that deactivate the Myc gene in humans. Felsher's experiments worked because the group could create a modified Myc gene that ...U-M team treating mouth wounds by engineering tissue grafts
.... These five patients are part of what is called a proof of concept study for the Food and Drug Administrat... team is working with five patients to demonstrate proof of concept. That is the precursor to moving into the trials that inform an FDA decision to approve a...Heat-controlled drug implants offer hope for future
...thic form. The insulin tests, said Lyon, serve as proof of a concept that this method of drug delivery is worth further investigation. Currently, the films release their cargo at 31 C, six degrees below human body temperature, but Lyon's group is working on pushing the release point to a temperature sligh...Obesity reversed in mice by destroying blood vessels that service fat cells
...ular liposuction." Moreover, the study is another proof of the concept of vascular "zip codes" which was first pioneered by Arap and Pasqualini. Blood vessels are not simply a uniform and ubiquitous "pipeline" that services all parts of the body, but are different depending on the kind of organ or tissue ...Cancer gene therapy news backgrounder: New ideas fuel next generation gene therapy research
...u describes himself as "very cautious; it's just a proof of a concept right now," he also says he is "excit...veness of the therapeutic virus. "We will have our proof of principle in treating gliomas," says Conrad. "If it is safe, and shows some benefit, we will want...AAN 2004 Public Leadership Award goes to Leon Fleisher, musician who overcame dystonia
...ndation. "His remarkable comeback as a musician is proof that people can recover from debilitating neurological disorders, and his selfless commitment on behalf of dystonia research and education merits a standing ovation in itself from the both the neurological community and society at large." Trained ...American Academy of Neurology awards 2004 Potamkin Prize to two scientists
...ttee and past President of the AAN. "Their work is proof that the fight against Alzheimer's disease is well underway, and progress is being made." Thal is one of the world's foremost authorities on the development of therapies for Alzheimer's disease. His pioneering clinical research work in the 1980s led ...'Off-pump' bypass surgery has similar outcomes, lower cost, than conventional bypass surgery
...omparisons such as the SMART trial demonstrate the proof of concept for OPCAB. "In the right hands and for the right patients, OPCAB offers safe, complete, and durable revascularization that may reduce complications relative to conventional CABG with cardiopulmonary bypass. The question of whether OPCAB s...Policy highlights from Tufts University Friedman School of Nutrition
... outlets but their availability is not necessarily proof that they are safe. Currently, because of a 1994 regulation, dietary supplements are regulated like foods rather than drugs, which means that they are considered to be safe unless proven otherwise. While most dietary supplements are safe when used as...Human studies show feasibility of brain-machine interfaces
... signals. While the new studies provide an initial proof of principle that human application of brain-machine interfaces is possible, the researchers emphasize that many years of development and clinical testing will be required before such neuroprosthetic devices are available. The research team, led by n...Key to proper blood vessel growth in eye and ear discovered
...-detecting retina. The work also offers the first proof that nature has site-specific growth signals that could one day be exploited to treat a variety of diseases in which blood vessels -- or the need for new ones -- play important roles, such as in cancer, heart disease and stroke. In their laboratory ...March 2, 2004, Annals of Internal Medicine tip sheet
...res. An editorial writer says that despite lack of proof that interventions work, the medical profession, which seeks "to meld science and art in the service of humanity," should remain vigilant and look and listen carefully for family and intimate partner violence among children, women or older adults (Ed......ases of NRT were obtained by a minor buyer without proof of age, despite warnings printed on the product," the authors write. "Given these findings, we conclude that the FDA-approved product labeling has little effect on actual sales practice. However, health practitioners recommending NRT to adolescent ...