Randomisation phase of the DIRECT programme (DIabetic REtinopathy Candesartan Trials) completed
...g the severity of diabetic retinopathy. However, a properly designed trial of sufficient size is needed to evaluate the role of RAS modulation in the treatment of this condition. Candesartan cilexetil was chosen for DIRECT because it may offer a more complete blockade of the RAS with improved tolerability. D...NIH researchers test promising new therapy for blinding eye disease
... which tissues in the eye become inflamed. If not properly treated, chronic inflammation causes scarring and leads to irreversible vision loss. Currently, people with severe uveitis must take steroids or other drugs that suppress the immune system to control the inflammation. Unfortunately, these powerful...Orthokeratology contact lenses cause permanent vision loss in children
...oxygen transmission or whether the lenses had been properly fitted for the patients. Factors that may have contributed to the increased risk of corneal ulcers and infection included: Overnight wearing of the OKLs that may have deprived the corneas of oxygen, The OKLs are designed to improve centrali...Babies conceived with medical assistance face high risk at birth
...sisted reproduction programmes should also be made properly aware of these risks, say the authors, and more work should be done on reducing risks for babies conceived with medical help. Twenty-five years after the first IVF baby, they conclude, serious challenges persist for reproductive medicine....Successful, rapid protein crystallization possible with technique developed by UCSD researcher
...e a protein is knowing whether it is really folded properly or has some disordered regions that might prevent crystallization," said Ian Wilson, DPhil., JCSG principal investigator, one of the PNAS authors and a professor of molecular biology and Skaggs Institute for Chemical Biology at TSRI. "So, no matter h...Hospital volume may not be best criteria for selecting hospital for coronary bypass surgery
...analyses using contemporary analytic techniques to properly account for clinical factors, differences in site variability, and clustering within sites. We found that, compared with high-volume hospitals, low-volume hospitals tended to operate on patients with higher risk and under more emergent conditions," t...Placebo-controlled clinical trials put children with asthma at risk
...eason, it's "unconscionable" that children are not properly treated when joining these studies. "Those who don't get the experimental drug should get standard treatment." The researchers chose to scrutinize asthma research because the respiratory disease is one of the most common chronic conditions of ch...Standardized blood pressure measurement could improve hypertension prevention, care in the Americas
...hould be seated during the examination, and how to properly choose and position on the person's arm the cuff of the blood pressure measurement device. The article covers a number of related issues, including proper types of equipment, calibrating the equipment, training and certification for the techni...New study in Pediatrics shows nitric oxide therapy for newborns effective and cost saving
...d-vessel walls in the lungs, allowing the lungs to properly oxygenate the blood and provide it to the rest of the body. As with all pharmaceuticals, inhaled nitric oxide has side effects. The treating physician needs to assess the risk versus the benefit for the individual patient. This study was supported in...New study in Pediatrics shows nitric oxide therapy for newborns effective and cost saving
...d-vessel walls in the lungs, allowing the lungs to properly oxygenate the blood and provide it to the rest of the body. This study was supported in part by a grant from INO Therapeutics, Inc., which manufactures INOmax....Patients and doctors lack knowledge about adrenaline injections
...uld therefore ensure that patients and parents are properly educated, they conclude....Glycerin may help skin disease, study finds
...serving as a substrate to allow the skin to mature properly and, when you don't have enough glycerol in the skin, cells don't mature properly and that is why you get hyper-proliferative, thick skin," Dr. Bollag says. A mouse model for dry, f...Buckwheat may be beneficial for managing diabetes
...characterized by the inability of cells to respond properly to insulin. Przybylski is currently collaborating with Kade Research Ltd., a Canadian-based company involved in research and development of new buckwheat varieties that contain much higher amounts of chiro-inositol for food applications....The Endocrine Society responds to Institute of Medicine report on testosterone therapy for older men
...5 before committing the time, energy and cost of a properly powered study of the long-term benefits and risks of testosterone therapy in this age group. The Endocrine Society supports the IOM panel in their efforts to help the public and the medical community better understand the existing body of ...Jefferson scientists use gene therapy to restore function of damaged heart cells in laboratory
... the beta-adrenergic receptor system fails to work properly in individuals with end-stage heart failure. Such receptors "drive the heart both by rate and force of contraction," he says. The researchers' target has been the beta-adrenergic kinase (ARK1), an enzyme that is elevated in human heart failure. On...Cancer patients find more pain relief when treatment guidelines are followed
... pain. Health-care providers are often not trained properly to assess pain, have an inadequate knowledge of proper medications and interventions, and fear side effects and addiction. Patients, too, worry about addiction and side effects, and they also may have a reluctance to complain. "By following guideline...Fashionable, nonprescription contact lenses may pose a danger to your eyesight
...fit and teach the patient how to handle the lenses properly and how to keep them sterile. The doctor will monitor the patient to make sure problems don't develop later. The risk for corneal ulcers the most serious adverse affect of contact lenses and considered ophthalmologic emergencies among prescription ...Report cites risks associated with over-the-counter cosmetic contact lenses
.... They did not receive any instructions on how to properly care for or wear the contact lenses. And all of them were sold individual contact lenses without a prescription, an examination or a fitting by an eye care professional such as an ophthalmologist. According to the case report: One 14-year-old pat...Gastric bypass surgery resolves or improves diabetes in most patients, reports Pittsburgh study
...n form of diabetes, in which the body is unable to properly use the insulin that it produces. About 80 percent of people with type 2 diabetes are overweight....Post-stroke treatment with antidepressants appears to reduce death rate
...ay poorly control their diabetes by failing to eat properly and failing to take medications. However, a non-depressed person with diabetes may be more attentive to these important self-care measures. Depression also may be associated with changes in platelet function. Platelets play a role in blood clotting a...