EXANTA (TM), an oral direct thrombin inhibitor, significantly reduces risk of VTE in major OS
...) - when treated with EXANTA, compared to standard prophylaxis with enoxaparin (40mg od). The relative risk reduction in major VTE was 67 per cent (1.8% vs 5.5%) for total hip replacement and 60 per cent (3.3% vs 8.2%) for total knee replacement surgery. EXPRESS is a randomised, double-blind study of 2,800 pati...Family focus is hallmark of new South African grant
...cial support services, risk reduction messages and prophylaxis of opportunistic infections. We believe this research ultimately will benefit the many families living in the shadow of HIV/AIDS." The inauguration of this project was also marked today by a commemoration at Soweto's Chris Hani Baragwanth Hospital. D...American Thoracic Society Journal news tips for October (second issue)
...nducted to date designed to investigate antibiotic prophylaxis in critically ill patients. As contrasted to placebo, the total number of infections among the 256 treated patients was much lower (141 infections versus 274). The authors discovered that the treated patients had fewer: cases of pneumonia (6 versus...Therapy for mice with prion disease could offer benefit to human beings with CJD
...velopment of improved diagnostics and postexposure prophylaxis are urgently needed given the unknown prevalence of subclinical prion infection associated with the BSE outbreak."...MTCT-Plus makes HIV treatment a reality for poor countries
...ices that includes education, counseling, support, prophylaxis and treatment of HIV. Psychosocial support, patient education, and counseling. Support for community outreach and education, and linkages to local organizations and resources. Procurement and delivery of antiretroviral therapy and other treatments...Drug cocktail prevents hepatitis B virus from recurring after liver transplant
...y issue of the Annals of Surgery, showed the viral prophylaxis therapy or preventive treatment of hepatitis B immune globulin (HBIg) and lamivudine in combination prevents recurrence of HBV infection and lengthens patient survival rates following liver transplantation. Researchers studied a total of 3,094 liver...Antiretroviral therapy around childbirth reduces risk of mother-to-child HIV-1 transmission
...ealth has been long-standing. Typical of perinatal prophylaxis trials, the PETRA report mentions no maternal-health endpoints and no maternal mortality data later than 6 weeks after birth. 10-15 years into the pandemic when these trials were conceived, treatment access and success had not been widely demonstrate...... programme, including venous thromboembolism (VTE) prophylaxis in orthopaedic surgery, deep vein thrombosis (DVT) treatment, stroke prevention in atrial fibrillation and acute coronary syndrome. To date, more than 15,000 patients in 30 countries have been involved in clinical trials....New data support the efficacy and safety of the novel oral anticoagulant Exanta
...ase III results from US and European trials of VTE prophylaxis in orthopaedic surgery. These data show that Exan...e III trial, one of the largest ever trials of VTE prophylaxis in orthopaedic surgery, included 2788 patients undergoing total hip or total knee replacement surger...First large-scale clinical study establishes the efficacy of the new oral anticoagulant H 376/95
...venous thromboembolism is the use of anticoagulant prophylaxis e.g. injectable low molecular weight heparin or or...r low molecular weight heparin and warfarin in the prophylaxis of venous thromboembolism in orthopaedic surgery." The METHRO II study was a double-blind, dose-find...Even in an era of HAART Drugs, HIV patients are vulnerable to opportunistic infections
...the respiratory tract of HIVpatients who underwent prophylaxis therapy to prevent a bacterial infectioncaused by Mycobacterium avium complex (MAC), which causes serious illness thatultimately leads to wasting and death if untreated. Findings from the CMV research were both good and bad, said Mark Jacobson, MD,le...Antibiotic Prophylaxis Could Help Prevent Respiratory Infections in the Critically Ill
(Effectiveness of antibiotic prophylaxis in critically ill adult patients: systematic revie...search in Italy, investigate the use of antibiotic prophylaxis to prevent this type of infection happening. The authors found that if the most effective antibiotic...Need For HIV Guidelines For Health Workers In Developing Countries
...r body fluids. With such effective post-exposure prophylaxis available, if an in-country employer is not able to afford the cost and storage of such drugs then should health workers be given a personal supply before travel? Gilks and Wilkinson conclude that there is a need for realistic, usable guidelines for...TB Prophylaxis Unnecessary In HIV-Infected People With Anergy, Study Suggests
... 10 percent. To determine the effectiveness of INH prophylaxis in this population,investigators in NIAID's Terry Beirn Community Programs for Clinical Research onAIDS (CPCRA) divided more than 500 high-risk HIV-infected people with anergyinto groups that received either daily INH or placebo. They found that the...ACTG 315 Preliminary Results: Drug Cocktail Restores Partial Immune Function
...icians should becautious about backing off from OI prophylaxis once it is indicated,despite early increases in CD4 counts." In the three-month analysis, Dr. Lederman's group found that the increase in CD4+ T cells couldbe attributed to both more memory cells (those that have encounteredHIV before) and more na&iu......ters for Disease Control and Prevention) for early prophylaxis against P. carinii pneumonia in all HIV-exposed children may prove particularly beneficial in children under the age of six months," the authors conclude. "Therapeutic approaches will need to be more aggressive among these infants, with earlier use ...