Tag: "protease" at medical news

AIDS Treatments Seek To Eradicate Virus, Restore Immunity

...ial is inserted in a hostcell's gene. Ritonavir, a protease inhibitor that received FDA approvalearlier this year, kills HIV by crippling an enzyme crucial to its survival,a mechanism different from other anti-viral compounds. The three drugs are expected to reduce the "viral load" or theamount of HIV in pa...

ACTG 315 Preliminary Results: Drug Cocktail Restores Partial Immune Function

...sistsof zidovudine (AZT), lamivudine (3TC) and the protease inhibitorritonavir. Protocol chair Michael M. Lede...l therapy (HAART) --drug combinations that include protease inhibitors -- can experiencedecreased plasma levels of HIV, increased circulating CD4+ T cellcounts,...

NIAID Stops AIDS Study Prematurely Because Drug 'Cocktail' Boosts Survival

...s have found a three-drug "cocktail" including the protease inhibitor indinavir significantly reduced AIDS sym...dy medications were well-tolerated." Indinavir, a protease inhibitor, works by preventing protease enzymes from cutting up proteins needed to form viruses, Ero...

Substance from Grapefruit Juice May Make Medications Safer

...ssure) and some immunosuppressants, sedatives, and protease inhibitors (used to treat AIDS). Although the "grapefruit juice effect" was discovered serendipitously almost a decade ago when scientists gave volunteers grapefruit juice to mask the taste of a medication, researchers did not know how the effect wo...

Researchers Finding May Boost Effectiveness Of Anti-HIV Drugs

... The finding raises hope that the effectiveness of protease inhibitorscould be boosted by combining the anti-H... quantities of Pgp, the VUMCresearchers found that protease inhibitors were not readily absorbed by thecells. In the body, Pgp is present in the intesti...

"Powerful New Tool" For AIDS Is Reported In Science

...nt of T cell counts and the patients' responses to protease inhibitor therapy in AIDS. T cells were indeed being destroyed with a higher degree of efficiency in AIDS patients than in healthy people without HIV infection, but more important is their body's capacity to form new cells. "We at Berkeley/UCSF are ...

Declining National Rates Of HIV-Related Deaths And Illnesses Due To Combination Antiretroviral Therapy With Protease Inhibitors

...on antiretroviral therapy --specifically including protease inhibitors -- dramatically reduces death ratesand ...din prescription of combination regimens including protease inhibitors from 2percent in mid-1995 to 82 percent by June 1997. Similarly, incidence of thr...

First Patients Enrolled In NIH Clinical Trial On Effects Of Marijuana In HIV Patients

...potentialinteractions with antiviral drugs such as protease inhibitors. Named the "Short-Term Effects of Canna...vir ornelfinavir, the two most commonly prescribed protease inhibitors for HIVinfection. "Our main goal is find out what is safe for HIV/AIDS patients. We know...

Crystal Structure Of gp120 Reveals HIV In Action

...ucture of HIV protease, which led todevelopment of protease inhibitors. But X-ray crystallography requires crystallizing a compound, which wasno small feat for gp120. "The mechanisms that HIV has to protect itself from the immunesystem also make it difficult to crystallize," says Dr. Kwong. Those prot...

Answers To Access, Adherence And Tolerance Of Protease Inhibitors

...atients who tried one or more of the fouravailable protease inhibitors eventually discontinued the drug. The m... Brown University. "Patients can only benefit from protease inhibitors while they are taking thepills," Stone says. "If it turns out that regular patients in cl...

Powerful AIDS Drugs May Promote Heart Disease

...t, but all the women had takencocktails containing protease inhibitors. The study also documented another side effect. Of 116 women who were treatedwith the popular drug protocol at the Miriam Hospital Immunology Center inProvidence, R.I., 21 complained of the body fat changes, some as early as sixweeks into ...

Many Gay Men Infected With HIV Are Opting To Delay Treatment, Despite Availability Of Drugs

...s--were using multiple-drugtherapy consisting of a protease inhibitor in combination with otheranti-retroviral drugs. The study found no major differences in the rates amongthe cities. "What I found surprising was the inability to detect differences based on incomeor ethnicity," Stall said. "All were in the...

Only Eight Percent Of San Francisco HIV-Positive Urban Poor Receive Protease Inhibitors

...or HIVinfection. For those HIV-positive people on protease inhibitors, theresearchers looked at three measure...e infected with HIV--andonly eight percent were on protease inhibitors prescribed by the San Franciscopublic health system. Although these people are HIV posit...

Study Shows Efavirenz Promising In Treating Pediatric HIV Infection: Leads To Approval Of New Drug For Testing HIV-Infected Children

...herapy consisting of efavirenz, the protease inhibitor nelfinavir and nucleoside ...ad not been previously treated with protease inhibitors or NNRTIs, and were able to swallow capsules. The median ag...

Study Shows Three-Drug "Cocktail" Needed To Keep AIDS Virus Curbed

...y to suppress the deadly particles. Indinavir, a protease inhibitor, works by preventing protease enzymes from cutting upproteins needed to form viruses, Eron said. Zidovudine and lamivudine work by...

Study Finds Less Intensive Treatments May Not Maintain HIV Suppression

...l,phase of the study, all individuals received the protease inhibitor indinavir(IDV) in combination with zidovudine (AZT) and lamivudine (3TC). After six months, more than 300 individuals whose viral loads had been reducedto 200 or fewer copies of HIV RNA/ml of blood were randomized to receive eitherthe same...

HIV Patients Treated With Protease Inhibitors Are More Likely To Engage In Risky Sex, Emory Researchers Report

...atients living with HIV who are being treated with protease inhibitors may beless concerned about practicing s...s living with HIV and found that thosetreated with protease inhibitors were more likely to report inconsistent condomuse compared to persons not treated with pr...

New Protease Inhibitor Could Thwart AIDS Resistance To Current Drugs

Researchers have developed a new protease inhibitor effective against mutatingstrains of the...tly. "We have studied the mutation pattern of HIV protease from patientswho take the existing drugs and found that the enzyme often rejects the drug byreducing...

A Note of Caution: Be Careful When Mixing Grapefruit Juice With Rxs

...rugs we studied, such as immunosuppressives andHIV protease inhibitors, patients may get a further increase in absorption bytaking their drugs a couple of hours after a glass of grapefruit juice. According to Dr. Benet, Patients who have not previously taken their drugs withgrapefruit juice should be very cau...

Study Finds Combining Exercise With Male Hormone Therapy Benefits Men With HIV-Wasting Disease

...g treatmentwith HIV anti-retroviral drugs known as protease inhibitors. "This is an important point because ...he total study population, 13 patients were taking protease inhibitorsas a treatment for HIV infection. They were represented evenly in both groups. Study...

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