New study in 'Nature' demonstrates protection against cell death during heart attack
...covered that blocking a particular protein in mice protects the heart from injury due to loss of blood flow du...hilin D, it also blocks calcineurin, an agent that protects the immune system. Fortunately, there are so-called analogs of cyclosporin that block cyclophilin D...Suppressing the cells that trigger cat allergy
... studies have suggested that keeping pets actually protects against later allergy - i.e., that early exposure may somehow modify an individual's immune system to tolerate specific antigens. Various attempts to modify abnormal immune responses to specific allergens, such as those to cat dander, have been made....US attempting to flout ethical practice for patient trials abroad
...ving a widely accepted code of medical ethics that protects patients who take part in trials is not necessary for studies conducted abroad, states a comment in this week's issue of THE LANCET. The 2000 Declaration of Helsinki, produced by 82 national medical associations, states that: "At the conclusion of th...Component of green tea protects injured livers in mice
... that "the data presented here indicates that EGCG protects the steatotic liver from I/R injury by reducing hepatic fat content, increasing energy stores, serving as an antioxidant and may stimulate the production of additional antioxidants such as GSH." They add that these activities warrant further investig...Wine keeps women's hearts beating healthily
... effects on HRV may be one of the reasons why wine protects heart health, suggest the authors....Transport system smuggles medicines into brain
...he brain, the so-called blood-brain barrier (BBB), protects the brain from toxic substances. It only lets through important nutrients for the brain such as iron, glucose and oxygen. Visser allowed larger molecules, such as medicines, to pass through the blood-brain barrier by attaching these to the iron-conta...Carrot component reduces cancer risk
...d the development of anti-cancer drugs. Falcarinol protects carrots from fungal diseases, such as liquorice rot that causes black spots on the roots during storage. The scientists investigated the compound after a previous published study suggested it could prevent the development of cancer. The research tea...Rheumatoid arthritis patients have double the risk of heart failure
...en," says Dr. Nicola. "This suggests that whatever protects women from heart failure compared with men in the general population is not the same in patients with rheumatoid arthritis." Heart failure is a serious disease, according to Dr. Nicola, causing a survival as short as most cancers. He indicates that ...Substance protects resilient staph bacteria
...ne altered to produce excess PGA--to show that PGA protects S. epidermidis from innate immune defense, human antibiotic compounds and salt concentrations similar to levels found on human skin. Dr. Otto's group also used mice fitted with catheters to demonstrate that the S. epidermidis strain deficient of PGA ...Rat whisking may provide insight into debilitating eye disorder
...r in blepharospasm. Normally, the blinking reflex protects the eye from bright light and other environmental hazards, but in blepharospasm this blinking response gets out of control. The resulting muscle spasms can be so intense that the eyelids remain forcefully closed for several hours at a time. "The ...Study estimates number of excess cases of coronary heart disease caused by Vioxx
...IDs. Previous studies have suggested that naproxen protects against coronary heart disease. Dr Graham comments: "An estimated 88,000-140,000 excess cases of serious coronary heart disease probably occurred in the USA over the market life of rofecoxib. The US national estimate of the case-fatality rate (fatal ...Study shows drugs such as Vioxx and Celebrex were widely over-used long before recent problems
...ich triggers inflammation, as well as COX-1, which protects the stomach lining and helps to decrease the risk of GI bleeds and stomach ulcers. These newer and far more expensive drugs were designed to target only COX-2 and to be used to treat patients with chronic inflammatory disorders such as arthritis. Th...Study of CPR quality reveals frequent deviation from guidelines
...rest. CPR "buys you time," explained Abella. "It protects your heart and brain until we can get your heart pumping again," which usually requires shocking it back into a normal rhythm. The study authors have used their data to launch an effort to increase the quality of CPR delivered at the hospital, combi...Penn researchers add more evidence to demonstrate role of COX inhibitors in heart-disease risk
... main source of a fat prostacyclin or PGI2 which protects the heart from factors that activate the clotting system, harden the arteries, and raise blood pressure. "Although a clinical trial is a crude detection system for uncommon side effects, such as the cardiovascular risk from coxibs, we predicted that ...Antibiotics protect nerves in mice by turning on genes
...other transporters, too." Because ceftriaxone only protects against glutamate damage, just one problem in ALS, it's not surprising that the mice eventually succumbed to weakness and paralysis despite treatment, he says. "If we can find drugs that protect against other causes of nerve death in ALS, the combina...Blocking molecules protects health of implants
New Haven, Conn.--Blocking a key molecule protects breast implants, permanent catheters, pacemakers, artificial joints, glucose sensors for diabetics, and other biomaterials from rejection and damage by the body, according to a study published this month in The American Journal of Pathology. The more...NIH halts use of COX-2 inhibitor in large cancer prevention trial
...eat and prevent disease and to do so in a way that protects the lives and safety of the participants." NIH sponsors over 40 studies using celecoxib for the prevention and treatment of cancer, dementia and other diseases. In light of these new findings, NIH Director Zerhouni requested: a full review of all N...Study suggests Akt3 protein is key to melanoma's resistance to chemotherapy
...aggressive," Robertson said. "The Akt3, in effect, protects the cancer cells from the normal signals that would tell them to die. Using samples of human melanoma tumors, we found that levels of active Akt3 increase progressively during melanoma tumor progression with highest levels present in advanced-stage m...Got heart disease? The answer may be in your fingertips
...lium that lines the blood vessels. The endothelium protects vessel walls from injury and helps modulate their expansion and contraction to maintain appropriate blood flow and blood pressure. Endothelial dysfunction is the earliest measure of functional abnormality in the blood vessels, so coronary endothelial...Understanding how prostaglandin prevents gut injury during radiation therapy
...ol of Medicine pursued the mechanism by which PGE2 protects against radiation-induced injury in mice. They demonstrate that radiation-induced cell death can be dependent or independent of the bax protein, however the beneficial effect of PGE2 treatment is only achieved via a bax-dependent mechanism. Bax is n...