Artery Temperatures Identify Hot Spots On Plaque That May Rupture And Trigger Heart Attack
...eratures rose. "The correlation between C-reactive protein andincreased temperature in coronary plaques supports the theory that temperatureis due to acute inflammation," Stefanadis says. Co-authors are Leonidas Diamantopoulos, M.D.; Charalambos Vlachopoulos, M.D.;Eleftherios Tsiamis, M.D.; John Dernellis, M......Over the next 18 years, the results of his soybean protein researchproduced numerous patents and successful products for Glidden, among them, apaper coating and a fire retardant foam used widely in WWII to extinguishgasoline fires. In the biomedical area, Julian's research made it possible toproduce large q......, Dr. Pulst will announce the recentdiscovery of a protein that is involved in causing human brain tumors.Identified by a member of Dr. Pulst's team, this protein binds to a protein thatsuppresses tumor growth. The presence of the tumor-suppressing protein appear...Repeated Exposure To Cocaine Alters Brain Structure
...rigger neuronal activity-expression of the nuclear protein c-fos--in thenucleus accumbens, the prefrontal cortex and other brain regions associated withlearning and emotion. "The fact that classical conditioning may produce alterations in neuronal geneexpression suggests that the craving and relapse associat...New Vaccine Provides Protection From HIV In Monkeys
...response generated by the insertedDNA. 3) purified protein vaccines - proteins for the viral envelope areproduced in culture, outside the body, and are then injected. In testing combinations of these three subunit approaches, Dr. Robinson'sresults show that the a...New Type Of Artificial Surfactant Shows Promise In Treating Lung Disease
...ons. "In our studies we overcame the absence of protein by adding the polymer,"Taeusch said. The new research on artificial surfactant is an extension of breakthrough workby UCSF scientist John Clements, MD, who was first to isolate and characterizenatural lung surfactant in the 1950s. Twenty years lat...Biochemical Marker Targets Brain Injury Leading To Movement Problems After Stroke
...lear, but studies suggest it may beassociated with protein building and the transmission of signals between nervecells. The researchers found reduced concentrations of NAA in a particularbrain region were linked with weakness in patients with stroke. This region,known as the internal capsule, has nerve pat...Jefferson Researchers Report Progress In Using Vaccinia-Based Vaccine For Melanoma
...ave inserted a gene for an immune-system enhancing protein intothe tumor cells of advanced melanoma patients, using the time-tested vacciniavirus as their vaccine vehicle. The gene encodes granulocyte macrophage colony stimulating factor, orGM-CSF, a substance which revs the body's immune reaction. ...Immunex Advances CD40 Ligand To Phase II Clinical Trial In People With Metastatic Kidney Cancer
...etween the ages of 50-70 years. CD40L is a protein primarily expressed on the surface of activated CD4+T cells. Its receptor, CD40, is expressed on B cells, antigen presenting cellssuch as dendritic cells, macrophages and on some other normal and tumor cells. Engagement of CD40 on antigen presenting...Biological Markers Found That Correlate To Esophageal Cancer Treatment Success
...rch team analyzed tumor samples forgenes and their protein products that studies of other cancers, such as co...ients= response to therapy,Harpole found the three protein markers whose presence or absence significantlyimpacted patient survival. The presence of one such m...Cholesterol Carriers Better Predictors Than Cholesterol For Second Heart Attack
...n activity inthe blood. Individuals with the blood protein profile of low apo A-1, high apo B, and highD-dime...eart disease. These reduce clotting activity. The protein tests, which can be performed in standard clinical laboratories, maybecome routine in the future, Mo...New Procedure Makes A Successful Transplant Possible
...cells and platelets. Their serum was replaced by a protein solution. Eight patients had this procedure six times over a two-week period. They alsotook anti-rejection medication to prevent the antibodies from coming back, usingthree new drugs: Prograf, Cellcept and IVIG. The rejection antibodies were success...Study Suggests Inflammation Signs Can Show Who Will Develop Diabetes
...nteers with the lowest levels of albumin, a common protein in bloodthat decreases during inflammation, faced ...bumin levels. Those with thehighest fibrinogen - a protein produced in the liver during inflammation andimportant to blood clotting -- showed about a 20 percen...Soy foods reduce risk of coronary heart disease
...ed intake of soluble fibreand replaced most animal protein with vegetable protein from soy, other legumesand cereals, meat substitutes and vegetarian cold cuts. Compared to the low-f...Study suggests a drug treatment for abdominal aortic aneurysms
...n healthy artery wall. They also attack elastin, a protein that helpsstrengthen the wall, enabling it to with...drugcontained two and one-half times as much MMP-9 protein as those from thedoxycycline-treated patients. And they contained five and one-half times as muchmes......and each step is mediated by a different enzyme, a protein thatspeeds and guides a biological process. With Auchus' guidance, Lee was assigned to investigate whether MPA works at highdoses by blocking the action of one of these enzymes. Studies of rats had shown that large doses of MPA might block the acti...Novel drug therapy tackles third 'pathway' causing congestive heart failure
DALLAS, June 29 -- A drug that inactivates a protein in the body that worsenscongestive heart failure could eventually lead to a new approach to treatingthis devastating disease. A preliminary clinical study involving the drug,called etanercept, is reported in today's issue of Circulation: Journal of ...Unexpected target may unlock the door to fighting sepsis
... Investigators found that when they blocked C5a, a protein product that isnormally activated by the immune system, they were able to provide a significantdegree of protection in sepsis-induced rats. C5a is a product of the mammaliancomplement system---a complex system of proteins and plasma that has powerful...Allergy-producing cells are also 'do-gooders,' helping stave off infections
...ed CD48 on the mastcell surface. CD48 recognizes a protein called FimH on the tips of hair-likeprojections on...ugh CD48 was discovered more than 10 yearsago as a protein that appears on the surface of some white blood cells such asmast cells, its biological role has not...Researchers discover treatment that delays onset of insulin-dependent diabetes
...reign nature of theaffected cells, in particular a protein named glutamic acid decarboxylase orGAD, from the ...y developdiabetes. The mice received the blocking protein from a very early age beforethey developed diabetes. The results showed a significant reduction in t...