Fat may promote inflammation, new study suggests
...eart disease, our study suggests that inflammatory proteins produced by fat itself may play a role." The study...ogy and Metabolism, evaluated whether inflammatory proteins produced by fat are linked to risk factors for heart disease, including high blood pressure, high ch...Some brain cells 'change channels' to fine-tune the message
Johns Hopkins researchers have identified the proteins that allow specific brain cells to "change channel... In the cells in the cerebellum, a channel made of proteins called AMPA receptors, built from subunits called GluR3 and GluR4, is usually found at the synapse. ...First mouse model for multiple system atrophy points to new treatment targets for brain diseases
... disorders seemed related, based on the -synuclein proteins in cells. In the clinic, many patients with MSA present with symptoms similar to Parkinson's disease (PD), and MSA has been misdiagnosed as such. Collectively, MSA now includes three related disorders characterized by their most prominent symptoms: ...Targeting mutant B-Raf protein reduces melanoma development
... imperative that we continue to look for important proteins that could be targeted therapeutically. Studies li...ntify how inhibiting important melanoma regulating proteins reduce melanoma development will lead to a better understanding of the disease, and thus, the develo...Chemical decoy shows promise for slowing Alzheimer's by acting as decoy
...coy that shows promise in blocking the toxic brain proteins thought to cause Alzheimer's disease was described...c. It is the diffusible beta amyloid species tiny proteins that can easily reach the brain that are thought to be toxic in Alzheimer's and associated with bra...Mechanism of RNA recoding: New twists in brain protein production
...c editing method cells use to expand the number of proteins assembled from a single DNA code. According to his...ety. RNA recoding lets cells generate an array of proteins from a single DNA sequence, each with a slightly different function. Producing different proteins i...Research suggests possible blood test for multiple sclerosis
...f there is a "fingerprint," or distinct pattern of proteins and peptides in people with MS. Proteins are made ...t was designed to look for a pattern of individual proteins that can differential people with MS from healthy people." The analysis combined mass spectrometry, ...Chemists identify immune system mechanism for methamphetamine binges
...howed that methamphetamine reacts with glucose and proteins to form a larger-size "glycated" product. This product is then recognized by immune system components, stimulating the production of antibodies to the drug. In follow-up studies using mice, those injected with the drug developed antibodies to it. "An...Earlier use of prostate cancer vaccines urged by Hopkins scientists
...ells and marking them for destruction. Changes in proteins on the T-cell's surface give clues to whether they "see" the cancer and are targeting it. Those cells that have been ignoring the cancer need time to regroup and multiply in order to mount an attack, the scientists say. T-cells multiplied three time...New ways to design safer & more effective topical (transdermal) drug delivery announced in the PNAS
...um Corneum (SC) is made of dead cells that contain proteins and lipid molecules which are arranged in bi-layer...ion are typically associated with the unfolding of proteins in skin cells. By studying the molecular properties of a CPE, its propensity to penetrate or irrita...Neuronal death and processing of Tau protein in Alzheimer's disease
...ubules (major cytoskeletal structures); in AD, tau proteins dissociate from microtubules and aggregate into NFTs. Inappropriate neuronal apoptosis (or neuronal cell death) is present in AD, as well as in other neurodegenerative diseases. In a previous study, the authors showed that tau is a substrate for the ...Study of obese diabetics explains why low-carb diets produce fast results
...could have, they did not compensate by eating more proteins and fats and they weren't bored with the food choices. In fact, they loved the diet. The carbohydrates were clearly stimulating their excessive appetites," said Boden. All patients stayed in the hospital for the length of the study to insure exact m...... content, and salivary-gland-specific proline-rich proteins that play a role for their sorting into secretion ...clusion that there is no common module in secreted proteins that ensure their sorting into secretion granules, and that this process therefore is of a passive n...Cockroach allergens have greatest impact on childhood asthma in many US cities
...es and other "dust traps." Dust mite allergens are proteins that come from the digestive tracts of mites and are found in mite feces. Researchers tested 937 inner-city children with moderate to severe asthma symptoms. The children, ages 5 to 11, were given skin tests for sensitivity to cockroach and dust mite...Researchers discover link between insulin and Alzheimer's
...chool have discovered that insulin and its related proteins are produced in the brain, and that reduced levels of both are linked to Alzheimer's disease. The findings are reported in the March issue of the Journal of Alzheimer's Disease ( http://www.j-alz.com ), published by IOS Press. "What we found is that ...Proteins found in urine of pregnant women could help diagnose preeclampsia
...atio for the presence or absence of three specific proteins that are normally secreted by human placenta. They...uses of hypertension. The ratio between two of the proteins correctly identified all the women who had severe preeclampsia. "It will take several years to devel...Potential treatment for Fragile X Syndrome demonstrated in fruit fly model
...protein, which controls the availability of select proteins involved in neuron-to-neuron communication. Senio...ling is a conserved function of the dFMR1 and FMRP proteins and that loss of dfmr1 function in flies leads to at least a subset of the cognitive and behavioral ...Molecule important in cell construction also critical in learning and memory
New Haven, Conn.--A family of proteins that help build the cytoskeleton, or the bones of the cell, also play an important role in learning and memory, according to a study published this month in The Journal of Neuroscience . Marina Picciotto, associate professor of psychiatry, pharmacol...CK2 protein sustains colon cancer cells by sabotaging ability to commit suicide
... enzyme composed of four small proteins--two alpha proteins and two beta proteins. The finding holds promise f... signaling complex). The DISC is a large jumble of proteins that interact with each other after TRAIL binds to the outer cell membrane. After DISC forms, an enz...Protein that promotes survival of stem cells might be key to poor leukemia prognosis
... investigators showed that growth factors (natural proteins that stimulate cells to grow), such as the "stem cell factor," trigger the expression of the Mcl-1 gene. This was an important clue to how cells control the powerful effects of Mcl-1. Other authors of this study are Hiromi Iwasaki, Christy C. Ong, He...