Brookhaven Lab and BioSET develop a synthetic peptide that enhances the effect of BMP-2
...ogenetic protein 2, or BMP-2. BMPs are a family of proteins in the human body responsible for the proliferation, repair, and differentiation of cells in many tissues, including bone. The researchers designed one portion of the peptide to target the BMP-2 receptor molecules that occur on the surface of bone-...St. Jude scientist to lead NCI Pediatric Preclinical Testing Program
...nohistochemical determination of the expression of proteins relevant to molecularly targeted new agent testing. New agents will be tested, when feasible, near the time that they are entering evaluation in adults with cancer and before their possible initial evaluation in children. Several standard chemother...IgG treatment during pregnancy reduces severity of rare, recurring liver condition in newborns
...purifying, identifying and cloning candidate fetal proteins for use in blood tests. Other future directions include other clinical trials and creating animal models of NH to further study the disease and perhaps improve postnatal therapy for NH. ...Longterm immune memory cells cells do not develop during chronic viral infections
... T cells kill the virus-infected cells and produce proteins called cytokines that prevent the growth of viruses and make cells resistant to viral infection. During the acute phase of a viral infection, activated CD8 T cells respond aggressively for a few weeks, then about five percent of them become "memory ...Pitt researchers identify biomarkers of lupus which could lead to quicker and better diagnosis
...eristic of SLE and combined measurement of the two proteins has high diagnostic sensitivity and specificity fo...them using flow cytometry to compare the levels of proteins in 100 patients who were confirmed to have lupus, 133 patients who had other diseases and conditions...Research on fabrics and cancer-fighting foods featured at ACS meeting
...he analysis of complex molecules such as peptides, proteins and DNA. Mass spectrometry is the technique used to map the human genome. (Thursday, Nov. 11, 5:15-6:30 p.m., Auditorium) Banquet honoring Ernest Eliel Professor Ernest Eliel of the University of North Carolina at Chapel Hill will be honored at a ...Researchers discover potential skin cancer prevention target
...rs of transcription 3 (STAT3) belong to a class of proteins called transcription factors that can lead to canc...ignals to divide. Transcription factors are potent proteins because they set off a cascade of events by activating numerous genes, which in turn lead to the pro...A key to pregnancy-associated malaria
...egnancies. Although a family of related malaria proteins that confer the ability to bind to the placenta had been identified previously, the role of this protein has remained elusive. Salanti et al now show that another member of this protein family, VAR2CSA, is selectively produced on the surface of infe...Molecular clock genes influence metabolism of sugar and dietary fats
...y. They found in mice that two of the well-studied proteins in the clock control the ability of animals to recover from the fall in blood sugar that occurs in response to insulin. The investigators demonstrate a role for the circadian clock proteins, Bmal1 and Clock, in regulating the day-to-day level...NIH awards OHSU $4 million biodefense contract to study tuberculosis
...art of the National Institutes of Health, look for proteins that activate the body's immune response to emerging infectious diseases. OHSU's team will focus on tuberculosis and will use cells from TB patients whose immune response has been successful at keeping the disease under control. The goal is to use t...Researchers shed light on cancer susceptibility using 'supermice'
...of human cancers. This locus encodes two different proteins that act together to check uncontrolled tumor development. A study to be published in the November 15 issue of Genes and Development illustrates the importance of these gene products in controlling cancer in mammals. The Tumor Suppressor group heade...Scientists discover enzyme crucial to HIV replication
...ell nucleus where they can then be translated into proteins to begin their most destructive work. The cellular enzyme represents a potential new target for developing improved HIV drugs, say the researchers from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes...Gene-silencing technique offers new way to fight drug-resistant leukemia
... Medicine. "Lyn kinase is a member of a family of proteins that we know plays a role in cell survival, growth, and development," explains Gewirtz. "CML cells, especially those that arise in Gleevec-resistant patients, are very dependent on its function." To disable it, the researchers used short interfering ...New finding could make addiction treatment more effective
...sleep. The primary generators of spindle waves are proteins called calcium channels that are involved with cell communication. These channels may also help to set the phase of sleep. Chronic alcohol consumption has been shown to disturb the function of calcium channels in the thalamus, a brain region i...Technology points to possible targets for epilepsy and Alzheimer's drugs
..."Being able to measure levels of a large number of proteins simultaneously is a step forward in understanding ...little is known about the hundreds of thousands of proteins that are manufactured by genes. Genes exert their effects through these proteins. Humans and other o...Animal study suggests safer immunization approach to Alzheimer's
.... "The vaccine reduces the accumulation of amyloid proteins for at least four weeks, providing a window during which other treatments could be used to prevent the formation of new plaques." Alzheimer's is an age-associated degenerative neurological disease and the leading cause of dementia in older people. An...New insights into hormone therapy highlight when estrogen best aids brain
...rvals) and examined them for the production of the proteins associated with neuron repair and the formation of...en, the estrogen-treated mice produced more of the proteins important for repair and neuronal function. However, with prolonged, continuous estrogen treatment, ...Researchers identify brain protein that halts progression of Alzheimer's
... on the study. "In Alzheimer's patients, the 'bad' proteins significantly outnumber the 'good' proteins." Johnson discovered the effect of transthyretin while studying mice genetically engineered with defective genes taken from human patients with early-onset Alzheimer's disease. As expected, the defective ge...Exercising limbs protects brain cells affected by Parkinson's, study in rodents shows
...it's because exercise stimulates production of key proteins that are important for survival of neurons," said ...l of Medicine. Called neurotrophic factors, these proteins protect neurons and promote their survival. According to the researchers' studies, one particular ne...New protein associated with aggressiveness in breast and ovarian cancer
...on blocking Ras function are now being tested. Rab proteins are anchored to intracellular membranes, and are activated when a receptor on the outside of the membrane is stimulated and the signal is brought into the cell. The "best current evidence" is that Rab25 is involved in deciding whether those internali...