Scientists Produce New Anti-Malarial Compound
...ing an electron-hungry carbon free radical. Carbon radicals damage cells insidethe parasite by stealing electrons and breaking molecular bonds,making the drug toxic to the malaria parasite. "Our understanding of that mechanism has allowed us to designstructurally simpler compounds that would follow that chemi...Antioxidant-Enhancing Drug Partly Rescues Noise-Induced Hearing Loss
...he stress of loud noisescauses an increase in free radicals in the inner ear, which can damage or killsensory cells. To defend themselves, sensory cells express a rush ofglutathione, an antioxidant that absorbs free radicals. R-PIA was found toincrease the activity of glutathione, thus providing enhanced pr...Preliminary Study Proves Centuries Of Herbalists Right About Echinacea
...radicals, and we know from otherresearch that free radicals are not a good thing. We want the free radicalsto kill microorganisms, but we don't want free radicals being produced allthe time because they will damage healthy tissues. "Because we don't have the scie......riodontal disease and infection," she said. "Free radicals are released as aresult of bacteria clearance and killing. Periodontal tissue depends on naturalantioxidants to overcome this oxidative stress and maintain homeostasis. Whenantioxidants are depleted, the ability of gum tissue to overcome oxidatives......at arehighly reactive forms of oxygen such as free radicals and peroxides. Thiscoupled with the discovery, about 10 years ago, that cADPR is involved in theregulation of calcium ions, led the Jacobson research team to hypothesize thatcADPR may be a key component in cell death, particularly in those situation...UI Researchers Identify Possible Reason For Rare, Accelerated Aging Condition
...ia, protect most people against cell-damaging free radicals known asreactive oxygen species (ROS). "Understanding the molecular mechanism underlying progeria may help to furtherexplain the molecular basis of normal aging, " said Larry Oberley, Ph.D., UIprofessor of radiology and the study's lead investigator....Two Beta-Blocker Drugs Equal In Treating Heart Failure
...els of antioxidants. Antioxidants soakup the free radicals that help form the fatty obstructions, called plaque, inblood vessels, which can trigger a heart attack or stroke. Individuals taking either of the beta-blockers for six months felt better, wereable to exercise longer without becoming exhausted, a...Cancer tumors shown to consume large amounts of vitamin C
...min C is a powerful antioxidantthat consumes free radicals - or toxic substances in the body that can also begenerated from chemotherapy agents to destroy cancer cells. "It's possible that taking large amounts of vitamin C could interfere with theeffects of chemotherapy or even radiation therapy, since the...Alcohol consumption triggers free-radical damage in the body
...er diseases, measuresof oxidant stress due to free radicals were significantly elevated. Ten healthy volunteers were given 0.4, 0.6, and 0.9 g/kg of a 98 percentsolution of grain alcohol, which raised their blood alcohol levels, on average,to .08, .10, and .13 g/dl respectively. The volunteers experienc...Extract from traditional Chinese herb enhances recovery in stressed cells
...wear and tear of the cell. A rapid buildup of free radicals in cells may be an underlying cause of death incar...dants like vitamin C and E work by binding to free radicals andpreventing them from doing damage to the cells. But vitamins C and E are slowto penetrate the ce...Studies suggest that eating chocolate may be good for your heart
...earchers observed a decrease in the damage by free radicals on blood lipids, a situation that can be associated with the prevention of heart disease. Earlier in vitro studies have also suggested that polyphenols found in chocolate may decrease LDL oxidation and modulate platelet activity, and earlier epidemio......ays to assemble compounds. Fifteen years ago, free radicals - the kind of molecules that opened up the ozone hole overAntarctica, for example - were considered too reactive to be useful in the laboratory. Butadventurous researchers like Curran have found conditions and strategies to channel that"hyperreactivi..."Radical" Discovery Advances Medicine and Plastics
...esignate Moses Gomberg's discovery of organic free radicals a National Historic Chemical Landmark at a ceremon...and pair up quickly. The existence of organic free radicals seemed unlikely, especially since all attempts to find one had proved futile. Gomberg succeeded whe...... and MetaPhore Pharmaceuticals confirmed that free radicals particularly superoxide anions produced in large...reatment of septic shock. Removing superoxide free radicals protects catecholamines like dopamine, norepinephrine and epinephrine from deactivation, restoring r...Drug therapy significantly extends lifespan of worms
Using drugs that help eliminate oxygen radicals -- the toxic byproducts of metabolism -- scientist... compounds are catalytic drugs that convert oxygen radicals to water, then reconstitute themselves in a cogwheel-like process that continues to destroy addition...NIH awards grant to MetaPhore Pharmaceuticals to study novel pain treatments
...e mechanism against oxidative damage from the free radicals derived from oxygen known as superoxide. That def... (SOD). The research will study the role of free radicals in pain and develop the SOD mimetics as potential drugs for pain relief, either administered alone o...FDA awards grant to metaphore pharmaceuticals to study septic shock in humans
...ans. However, the large quantities of oxygen free radicals produced by the body during this internal fight al...m sepsis patients to confirm the link between free radicals and falling blood pressure. Because free radicals convert catecholamines into a second class of com...Researchers identify promising target to slow Alzheimer's
...n cells, the modified version did not produce free radicals or kill brain cells, according to the researcher. ...an antioxidant, appears to work by destroying free radicals (oxidants) produced by amyloid, says Butterfield. "Our research provides an important insight ...Free radicals mediate arsenic's harmful effects
...tions in the cell that produce free radicals. Free radicals form naturally in the body during oxygen metabolis...xyl radicals, extremely reactive and damaging free radicals that attack cell membranes and DNA to create mutations. "As such, antioxidants could be an intervent...Animal studies indicate new approach for treating end-stage skin and kidney cancers
...eficient in cancer states. When in excess, free radicals particularly superoxide anions have been shown to deactivate a class of molecules, called catecholamines, which aid the bodys natural blood pressure regulatory system. By reducing superoxide, the synthetic SOD enzyme restores the levels of catech...