New Drug Prevents Breast Cancer In Postmenopausal Women, UCSF Researchers Report
...cancer, only 11 or .21 percent of those assignedto raloxifene developed the disease. However, like tamoxifen and estrogen,Cummings noted that raloxifene does increase a woman's risk of developing bloodclots. He added that raloxifene also reduced the ris......It was designed primarily toevaluate the effect of raloxifene on bone mineral density (BMD) and spinalfractures ...the drug was well tolerated and women who received raloxifene hadno higher incidence of uterine bleeding and breast tenderness than those whotook a placebo. The t...... as Zeneca's tamoxifen(NolvadexTM) and Eli Lilly's raloxifene (EvistaTM), also have anti-estrogeniceffects and t...rug leads were tested in parallel withestrogen and raloxifene for their ability to inhibit bone resorption. The studyconcluded that Signal's drug leads were twic......findings show that the osteoporosispreventive drug raloxifene (Evista®) reduces risk for newly diagnosed, in...er 10,000 postmenopausal women age 31 to 80 taking raloxifene for morethan three years had a 63 percent reduction in the incidence of newly diagnosed,invasive bre......d to receive either 60milligrams (mg) or 120 mg of raloxifene per day, or a matching placebo. Of thesewomen, 2,572 received 120 mg of raloxifene daily; 2,557 received 60 mg and oneplacebo tablet daily; and 2,576 received two placebo tablets dail...Estrogen has antitumor activity in hormone therapy-resistant breast tumors
...nt breast cancer cells. Widespread use of the SERM raloxifene for the prevention of osteoporosis has raised concerns that such women may eventually develop breast cancers that are resistant to raloxifene. Treatment of cultured raloxifene-resistant breast cancer cells with estradiol for 12 to 24 days inhibited ...In a new observational analysis, Risedronate significantly reduced nonvertebral fracture risk
...x months for a bisphosphonate, nasal calcitonin or raloxifene were excluded. All risk estimates were adjusted for age, sex, estrogen use, prior fragility fractures and a general morbidity indicator (number of concomitant medications). A six-month analysis was also done involving 7081 patients initiating thera...Pittsburgh, Feb. 13 -- The drug raloxifene significantly reduces the risk of invasive breast ...Medical Association. "The MORE trial showed that raloxifene reduces the risk of invasive breast cancer by 72 percent in women who took this drug daily for four ...UCSD researchers find raloxifene is not associated with early cardiovascular harm
...earchers have found that the osteoporosis therapy raloxifene HCl was not associated with early cardiovascular h...he study. The researchers found that four years of raloxifene therapy did not significantly affect the risk of cardiovascular events in the overall MORE study pop...Raloxifene following tamoxifen may offer no more reduction in breast cancer risk
A new study done in mice suggests that taking raloxifene after 5 years of tamoxifen therapy may not further...prevent the growth of breast cancers. What's more, raloxifene may stimulate the growth of endometrial tumors, conclude Ruth M. O'Regan, M.D., and V. Craig Jordan,...Raloxifene after tamoxifen not beneficial
Taking raloxifene after five years of tamoxifen therapy does not pre...thwestern evaluated the effects on tumor growth of raloxifene after tamoxifen treatment in mouse models of breast and endometrial cancers. They found that, afte...Annals of Internal Medicine, tip sheet, July 2, 2002
...ast cancer avoid taking drugs such as tamoxifen or raloxifene to prevent breast cancer. The USPSTF says that women at high risk for breast cancer and at low risk for serious side effects from the drugs should talk with their doctors about the risks and benefits of taking the drugs to prevent breast cancer. The ...New research suggests drugs might help women at risk of breast cancer
...that the studies were small and shorter-term." The raloxifene study, which focused on postmenopausal women with osteoporosis, showed a 76 percent reduction in relative risk. "These are pretty substantial effects and are worth considering," said the physician, a member of the UNC Lineberger Comprehensive Cancer ...M. D. Anderson breast cancer prevention study reaches three-year mark
...ncer and uterine sarcoma; possible side effects of raloxifene are blood clots in the legs or lungs. Women interested in enrolling in STAR may call the "STAR line" at 713-792-8064 or visit the Web site at www.mdanderson.org/star . For more information about breast cancer, call the National Cancer Institute's C...Researchers compare drugs used to prevent osteoporosis
...journals. According to information in the article, raloxifene helps prevent bone loss and increases bone mineral...mpared the effects of CEE and different dosages of raloxifene on bone mineral density in 619 postmenopausal women (average age, 53 years) with prior hysterectomy ...Study finds continued reduction in breast cancer incidence associated with longer use of raloxifene
...women with osteoporosis, 4 years of treatment with raloxifene was associated with a 72% reduction in breast canc... effect of an additional 4 years of treatment with raloxifene in the same group of women. In the CORE trial, more than 4,000 women who had been part of the MORE ...