Computer simulation shows how fibrils form
...omething to do with the general nature of proteins rather than with the specifics of the particular disease-associated proteins." Besides studying fibrils in the test tube, researchers would like to make computer models to view fibril formation. This is not possible using the traditional atomic-level pro...Chernobyl disaster caused cancer cases in Sweden
... already established tumors in their early stages, rather than that new tumors occurred....Ventricular regulation may be key to preventing heart failure
...a do not relate to the high atrial rate itself but rather to the concurrent high ventricular rate and the consequent development of heart failure," states lead researcher, Bas A. Schoonderwoerd, MD, PhD. Changes in atrial function and structure are known as atrial remodeling. Schoonderwoerd explains t...Policy-makers should enhance selection process for Presidential S&T appointments
...line could include conducting one background check rather than separate reviews by the White House and Senate, clarifying job criteria, and simplifying financial disclosure rules. Conflict-of-interest requirements also should be reviewed to ensure that they are neither too burdensome nor too lenient. APP......f water-rich foods and to select reduced-fat foods rather than full-fat ones. In both cases eating more low-energy-dense, water-rich foods, such as fruits and vegetables, was associated with lower body weights. "Decreasing the energy density of your diet by choosing more low-energy-dense foods, such as fr...Compound in apples may help fight Alzheimer's disease
...pound is mainly concentrated in the skin of apples rather than the flesh, Lee says. Products such as apple juice and apple sauce do not contain significant amounts of skin. In general, red apples tend to have more of the antioxidant than green or yellow ones, although any apple variety is a good source of q...Chemoprevention backgrounder: Working for a future of cancer chemoprevention
...ancer occurrence, because of time constraints, but rather look at the incidence of adenomatous (glandular) polyps, which are known to increase colon cancer risk. Based on that study, Lynch, an associate professor in the Department of Gastrointestinal Medicine and Nutrition, is heading another international ...Brain's immune system triggered in autism
...id Pardo. "We wanted a more definitive answer, so rather than looking at the overall immune system, we focused on immune responses inside the relatively sealed environment of the nervous system." Led by first author Diana L. Vargas, M.D., a postdoctoral fellow working in Pardo's laboratory, the resea...Stanford study reveals that cells linked to asthma and eczema also help cure deadly illness in mice
...e it," said Galli. To see the mast cells in action rather than in a culture dish, senior research scientist Mindy Tsai, DMSc, helped produce genetically engineered mast cells that could or could not respond normally to endothelin-1. The researchers could then selectively transplant these mast cells to mice ...Vegetable lovers should be viewed as different from fruit aficionados
...encouraged to try different spices with vegetables rather than meats and impress dinner guests with the right choice of wine. "For health professionals and educators, the importance of targeting different messages to differently predisposed target markets can mean the difference between a cost-effective pr...Uncoupling proteins in human heart
...enter the mitochondrial matrix; this produces heat rather than ATP. In isolated rat cardiomyocytes, mRNA levels of two UCP isoforms in the heart (UCP2 and UCP3) increase and concentrations of the insulin-responsive glucose transporter (GLUT4) fall in the presence of long-chain free fatty acids. To investiga...Marine sponge leads researchers to immune system regulator
... they target lipids, often bound to carbohydrates, rather than proteins. When presented with a lipid that may signal a threat, they pump out chemical signals, such interferon-gamma and interleukin-4, which tell other components of the immune system to rid the body of these invaders. Mice with defects in t...Generic anti-inflammatory causes significantly fewer GI complications than branded medications
...savings can be achieved if patients were to use it rather than branded medications such as Celebrex or Bextra," said Dr. Byron Cryer, associate professor of internal medicine at UT Southwestern, a VA physician and senior author of the study published in the November issue of Gastroenterology. "In the 13 yea...Heavy, lifetime alcohol users may be toasting metabolic syndrome
...e who tend to become involved in episodic drinking rather than moderate drinking should be discouraged." The researchers concluded that it is healthier to drink smaller amounts per drinking day than to drink more on fewer days, in line with current guidelines on moderate drinking. "The drinking pattern of...Drug-eluting stents adopted quickly, with early disparities
...een more as an impetus for further clinical trials rather than an immediate safety issue, since cardiologists have been placing traditional stents for more than 10 years and are comfortable with the procedure. Stents are tiny mesh tubes that are inserted into the site of a blockage in a coronary artery that...Limitations of current evaluation techniques for the cost-effectiveness of treatments
...ons in PD. It cannot replace clinical studies but rather complements them to better inform physicians and policy makers about the potential long-term effectiveness and costs of new and promising interventions. ...'Outgrown' a peanut allergy? Eat more peanuts!
...t these patients continue to avoid peanut for life rather than risk the chance of having a serious allergic reaction in the future when their allergy may recur," he says. In an accompanying study, also in the November issue of the Journal of Allergy and Clinical Immunology, Wood and colleagues report that w...Study of Big Ten football injuries shows NCAA rule change did not reduce injury rates
...s broken fingers or dislocated elbows or shoulders rather than the usual lower extremity injuries. The study results indicate that the way to reduce spring injury rates is to eliminate or reduce scrimmages and limited-contact practices leaving just regular contact practices where players play normally and a...MRI technique for measuring blood volume helps distinguish between abscesses and tumors in the brain
...ally removing tissue from the brain, but one would rather make the diagnosis by a noninvasive measure. The treatments for the two entities are also different: antibiotics for abscesses and surgical removal, chemotherapy or radiation therapy for tumors. A worst-case scenario would be one in which the wrong t...No justification for colposcopy in screening of young women for cervical cancer
...sue of THE LANCET suggest that regular smear tests rather than colposcopy is the best way of monitoring low-grade cervical lesions among adolescents and young women. Around 70% of sexually active women become infected with human pappiloma virus (HPV); around a quarter of women with HPV infection develop lo...