USC researchers define role of protein, discover cause of chromosome damage
...Lieber said, through oxidative free radicalshighly reactive atoms with an unpaired electron that can rip through our cells "like a bullet." "Our bodies are being riddled with these bullets every day," explained Lieber, "whether we like it or not. And the sorts of double-strand DNA breaks we were looking at ar...Early promise of simple screening for coeliac disease
...atographic assay, is a nitrocellulose strip with a reactive and a control zone. When the strip is dipped in serum or plasma, a positive result, indicating the presence of antibodies to transglutaminase, is seen as two dots on the strip. A negative assay shows only a control dot. Results are obtained in less t...Researchers link stroke patients' anger and aggression to brain injury
...ore likely a symptom of brain injury rather than a reactive behavior secondary to stroke, even in patients with physical disabilities," said Jong S. Kim, MD, Department of Neurology, Asan Medical Center, Seoul, Korea. "Anger and aggression seems to be a behavioral symptom caused by disinhibition of impulse co...Survey identifies drugs most likely to be found in the environment
... see in most European cities. Ozone, which is more reactive than chlorine, is widely used as a disinfectant in Europe, while we use chlorine. In Europe, the use of activated charcoal to remove trace organics in drinking water treatment is also much more prevalent than in our country. The Johns Hopkins study c...University of Pittsburgh transplant researchers present findings at international meeting
...widely used, less sensitive test called PRA (panel reactive antibody) based on lymphocytotoxicity. Such information may help clinicians tailor therapies to prevent rejection from actually occurring. In the study of pediatric heart transplant patients, ELISA performed before transplantation indicated that 10 ...Test identifies patients at risk for severe organ rejection, say Univ. of Pittsburgh researchers
...totoxicity, which determines a percentage of panel reactive antibody. Having more reliable information may help clinicians tailor therapies to prevent rejection from actually occurring. Indeed, in a retrospective study of pediatric heart transplant patients, four of the five "rejecters" were not identified a...Estrogen may lower women's risk of heart disease by working as damper on inflammation
...injection. Researchers measured the generation of reactive oxygen species, or oxygen free radicals -- components known to damage cells in blood-vessel walls and induce inflammation -- in specific cells (mononuclear cells), molecules (polymorphonuclear leukocytes) and in plasma. They also assessed concentra...Behavior plays key role in disease development and control, according to 10-year prospective review
...ess. Recent findings show that airways are just as reactive to psychological state as other physiological conditions. Asthma education programs that teach about the nature of the disease, medications and trigger avoidance tend to reduce the incidence of asthma. Psychological interventions showing promise when...Drug developed at Duke appears effective in treating respiratory failure in newborns
...ts SNO, not NO. "These free radicals are extremely reactive atoms implicated in the rebound phenomenon, as well as in the potential damage to other tissues and organs," Stamler said. "This problem has limited the use and efficacy of inhaled NO. It is still unclear how long the drug can be given safely." The c...JAMA study looks at role of pharmacist in health care
...ng a pharmacist work closely with individuals with reactive airway diseases such as asthma improved health out...f the American Medical Association. Patients with reactive airway diseases, costly and prevalent conditions, tend to visit the pharmacy with much more frequenc...Antioxidant reduces brain damage in stroke model
... hours following the stroke. Free radicals, highly reactive molecules, kill many of those cells. The researchers used a synthetic antioxidant, known as AEOL 10150, to neutralize the damaging free radicals and reduce cell death in a mouse model of stroke. AEOL 10150, developed by Dr. Crapo and his colleagues ...Doppler-guided fluid administration during surgery improves outcome
...ssure, urine output or heart rate. Instead of this reactive approach, the Duke researchers proactively used an...h fluid needs to be administered. "The traditional reactive indicators do not always accurately reflect the status of fluids, since the changes we see tend to o...Lauder supports James nutrition and breast cancer study
...le to detoxify certain metabolic byproducts called reactive free radicals. Some scientists believe that when free radicals build up in the body, they can lead to cancer. Paskett says changes in the metabolism of GSTM1 and GSTT1 as well as other chemicals in the women's blood and urine may turn out to be g...Brookhaven spotlights: News from the March 2003 American Chemical Society Meeting
...These reactions involve radicals, which are highly reactive molecules present in the combustion of fossil fuels. "Reactions between radicals are challenging to study," Fockenberg says, "because they lead to more reactions and products than those expected from the reaction of interest alone. Now, we can detect...Immune response to Alzheimer diseaserelated protein changes as we age
...hose with AD, contained elevated levels of T cells reactive towards Abeta, when compared to healthy middle-aged adults. While the general trend is for a diminished immune response with age, this finding demonstrates a very selective increase in the Abeta-reactivity of T cells with age in both healthy and AD-a...JCI table of contents, 1 August 2003
...hose with AD, contained elevated levels of T cells reactive towards Abeta, when compared to healthy middle-aged adults. While the general trend is for a diminished immune response with age, this finding demonstrates a very selective increase in the Abeta-reactivity of T cells with age in both healthy and AD-a...Illinois chemist wins national award for new drug research
...t's overproduced. Then it turns out to be a fairly reactive molecule that can degrade tissue," he said. "For example, there's evidence that it contributes to damage from stroke and diseases like Parkinson's, Alzheimer's and arthritis." The challenge is to block the overproduction nitric oxide in the brain wit...Cranberries may help reduce stroke damage
...ls, as they are exposed to excess levels of highly reactive oxygen species. Like a second-wave of attacks, these "superoxides" can continue causing brain cell damage and cell death for days and weeks after the initial stroke. Both groups of cells were then exposed to varying concentrations of cranberry extra......e Progenics team can induce high levels of broadly reactive neutralizing antibodies against HIV, and, if successful, whether such antibodies protect against HIV infection and AIDS. These vaccine development contracts are part of NIAID's expanded commitment to develop an HIV vaccine, and they complement other...