Tag: "receptor" at medical news

Unexpected benefit seen in treating HER-2 breast cancer with new preoperative drug combo

... to over-express the human epidermal growth factor receptor 2 (HER-2), a protein that fuels the growth, and thus the aggressiveness, of the cancer. Herceptin is a monoclonal antibody drug designed to block the action of these receptors, but use of the agent by itself has shown only modest benefits. The Food a...

OHSU scientists test medication to treat involuntary weight loss

...s based on earlier studies that demonstrated how a receptor on certain brain cells -- called the MC4 receptor -- can influence metabolism and appetite. Previous research involving mice demonstrated that when th...

A marker for new blood vessel formation in tumors

...tide, ([18F]Galacto-RGD), which binds tightly to a receptor - αvβ3 integrin -expressed in some tumors, especially in the blood vessels. As well as a role in angiogenesis, integrins are important in holding tumor cells together and connecting them with the extracellular matrix; what happens when the...

Novel therapy tested in mice could chase away cat allergies

...man antibody (called IgG Fc1) that docks to a cell receptor that can be recruited to stop allergic reactions. The investigators named the chimeric molecule GFD, or gamma Feline domesticus, for its human and feline parts, explains principal investigator Andrew Saxon, M.D., of UCLA. The cat allergen end of GFD...

Some brain cells 'change channels' to fine-tune the message

..." in the cell's membrane to open. Depending on the receptor and the channel, in will flow sodium, calcium, chloride or other charged atoms that then keep the communication process going. In the cells in the cerebellum, a channel made of proteins called AMPA receptors, built from subunits called GluR3 and GluR...

Scientist works on innovative treatments for brain tumors

... that glioblastoma cells have a particular type of receptor for interleukin 13 (IL 13), a naturally occurring protein that regulates the immune system in the body. Normal cells do not have these same receptors. Debinski developed a drug that combines a form of Il 13 with a toxin that kills cancer cells. By ta...

Genes for alcohol consumption identified

...ular genetic variant a version of the dopamine D2 receptor gene (DRD2) - was strongly associated with alcohol consumption. The DRD2 gene appears to influence the 'high' that people derive from drugs such as alcohol. People without this variant might derive less pleasure from alcohol, and may therefore drink ...

Blacks less likely to get expensive, newer heart treatments

...ntiplatelet drugs (including glycoprotein IIb/IIIa receptor blockers and clopidogrel), and angiotensin converting enzyme (ACE) inhibitors, if they have heart failure, diabetes or high blood pressure. Upon discharge, they should receive aspirin, beta blockers, clopidogrel, lipid-lowering therapy and ACE inhib...

Tumor-targeted immune cells cure prostate cancer in mice without causing systemic immune suppression

...d. After inserting a mutated form of the TGF-beta receptor into CD8+ T cells, Lee and associates transplanted the tumor-specific immune cells into mice that had been given a particularly aggressive form of prostate cancer, called TRAMP-C2. TRAMP-C2 prostate cancer cells produce large amounts of TGF-beta, an...

Proteins found in urine of pregnant women could help diagnose preeclampsia

...ental growth factor (PlGF), and their soluble VEGF receptor (sFlt1). The ratio of sFlt1 and PlGF had a high sensitivity (88 percent) and specificity (100 percent) for identifying severe preeclampsia, and was more accurate than proteinuria alone. Buhimschi said current tests such as liver function, proteinuria...

Studies underscore genetic involvement in nicotine addiction & aggressive hostility

... instructions to build a protein that is part of a receptor that recognizes acetylcholine, a major neurotransmitter that plays a role in the brain's pleasure system and also aids learning and memory, sleep, control of muscle movement, heart rate, blood pressure and more. Because nicotine is chemically very s...

Mood elevating hormone may trigger depression and heart problems

New Haven, Conn.--Impaired function of a receptor that regulates release of a mood elevating hormone...heart rate and blood pressure, suggesting impaired receptor function. The effects were more pronounced after the subjects were given a medication that blocked t...

Potential treatment for Fragile X Syndrome demonstrated in fruit fly model

...n increased activity in the metabotropic glutamate receptor (mGluR), which is located on the surface of neurons, including in the hippocampus the memory and learning center in the brain. In turn, this increased activity compromises neurotransmission for memory-associated functions. Jongens and colleagues su...

Resistance to chemotherapy

...inhibitors and inhibit the epidermal growth factor receptor (EGFR) kinase molecule. Both of them, gefitinib (Iressa) and erlotinib (Tarceva), have shown therapeutic benefits in a subset of patients with lung cancer. Recent work has helped to understand why some patients respond and some don't: responsive tumo...

Study finds new designer drug is potent treatment for chronic myelogenous leukemia

...hen constructed compounds that would lock into the receptor more securely than Gleevec. Investigators at Dana-Farber tested the new compounds to measure their effectiveness against CML in laboratory cell cultures and mice with the disease. Data from the study published in Cancer Cell showed that in experimen...

Gene signature can predict breast cancer spread

...nd tumour sizes, including women who had oestrogen receptor positive and negative breast cancer. Patients were followed up for an average of 8 years and 93 (33%) were found to have cancer that had spread to another part of their body. The investigators analysed 115 of the tumours for a selection of markers an...

American Thoracic Society Journal news tips for February 2005 (second issue)

...TIONSIN YOUNG CHILDREN Montelukast, a leukotriene receptor antagonist, significantly decreased the rate of exacerbations and lengthened the time between exacerbations in 2- to 5-year-old asthma patients who suffered from intermittent symptoms. The researchers pointed out that montelukast significantly reduc...

Johns Hopkins scientists receive presidential medals

... of candidate drugs, advances made possible by his receptor binding technology. In addition, Snyder's identification of novel neurotransmitters, such as the gases nitric oxide and carbon monoxide and D-amino acids such as D-serine, has radically reshaped concepts of neurotransmission. "This honor recognizes S...

Hypothyroidism associated with reduced breast cancer risk

...is well known phenomenon of cross-talk between the receptor of these hormones may promote or inhibit thereby determining the "fate" of a cell towards either a regulated growth or a cancer," he says. "If results of a planned M. D. Anderson prospective study bear out this conclusion, then it may be possible to ...

Study finds new designer drug is potent treatment for chronic myelogenous leukemia

...hen constructed compounds that would lock into the receptor more securely than Gleevec. Investigators at Dana-Farber tested the new compounds to measure their effectiveness against CML in laboratory cell cultures and mice with the disease. The final product was AMN107, a half-new, half-old hybrid. Half of AM...

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