Ugandan study highlights best drug combinations for treating malaria in Africa
...ted clinical experience and the high cost of these regimens are important obstacles. In Kampala, amodiaquine+sulfadoxine-pyrimethamine currently offers a readily available, efficacious, and economical alternativeAlthough the lifespan of amodiaquine+sulfadoxine-pyrimethamine might be limited by resistance, thi...Mayo Clinic researchers announce promising next generation treatments for multiple myeloma
...wly diagnosed with multiple myeloma. "These oral regimens are as effective as the standard intravenous chemo... side effects, and may in the future replace other regimens including the thalidomide-dexamethasone combination as initial treatment for myeloma," Dr. Rajkumar ...Cell marker identifies patients who are more likely to respond to taxol
...usztai. "If it doesn't, perhaps other chemotherapy regimens would work better." The results also suggest a way to improve the use of Taxol, Pusztai says. "If you block the effect of tau with an agent, you could possibly increase the effectiveness of Taxol in more patients, making them super responders." The...Novel antibiotic shows promise in shortening treatment duration of tuberculosis
...he World Health Organization (WHO). Also, cocktail regimens containing R207910 cleared infection in mice in half the time than the currently used regimen. "The drug acts through a novel mechanism of action, and is therefore active against all multi-drug resistant (MDR) strains of TB tested so far," says Dr. ...Re-analysis of large trials shows greatest benefit of chemotherapy in ER-negative tumors
...east Intergroup, all tested different chemotherapy regimens and doses in women whose cancer had spread to their lymph nodes, and all three showed statistically significant results. But, patients were treated "irrespective of hormone sensitivities or whether they had received tamoxifen or not," Berry says. In ...OTC treatment for acne as good as antibiotics
...mments: "Differences in cost-effectiveness between regimens were large; the cheapest treatment (benzoyl peroxi...propionibacterial resistance. By contrast, topical regimens that included erythromycin and benzoyl peroxide were unaffected by resistance but were not superior...Size of myocardial infarct measured using MRI
...s information for determining more accurate dosing regimens for stem cell therapies currently under development, in which upwards of 200 million stem cells are injected directly into the damaged heart muscle. "The size of a heart attack matters for determining how well a patient will recover from the trauma...Triple-drug therapy promising against African HIV subtype
Triple-drug antiretroviral regimens that are widely used in the United States and Euro...IDS morbidity and mortality. Since the triple-drug regimens have markedly reduced the morbidity and mortality associated with the subtype that predominates in d...Mayo Clinic Cancer Center receives SPORE grant for brain cancer research from NCI
...ard therapy. Clearly more effective and less toxic regimens are needed." Over the next five years, research activities may also extend to gliomas of children and adolescents, as brain tumors are currently the most common cause of cancer deaths in those age groups. All four SPORE projects are based on research...American Thoracic Society Journal news tips for January 2005 (second issue)
...treated patients as compared with two fixed dosing regimens that were also tested. The study was conducted at 246 centers in 22 countries. Patents were randomized to one of three treatment groups: budesonide/formoterol (bud/form) twice a day plus the same combination as needed for relief of symptoms; bud/fo...Mayo Clinic discovers a key to 'low metabolism' and major factor in obesity
... require special or large spaces, unusual training regimens or gear. Unlike running a marathon, NEAT is within the reach of everyone," Dr. Levine says. So promising is the role of NEAT in explaining obesity that Dr. Levine believes further studies are warranted to help expand scientists' understanding of the...Controversial Atkins Diet may be beneficial for people with epilepsy
... has recently been published. Among those dietary regimens is the low-carbohydrate Atkins Diet which has proven successful in suppressing epileptic seizures in a small series of patients. The review, published in Epilepsy Currents, explores the benefits of low-carb, high protein, and other restricted dietar...Other highlights in the February 2 JNCI
...ype of Leukemia After treatment with chemotherapy regimens that include the drug cytosine arabinoside, children with Down syndrome who have acute myeloid leukemia (AML) have much higher survival rates and lower rates of relapse than non-Down syndrome AML patients. A new study has found that a gene mutation c...New treatment rivals chemotherapy for lymphoma, U-M study finds
...ed for follicular lymphoma, including chemotherapy regimens that take months to complete. It's very well-tolerated by patients and we saw complete remission in the majority of patients lasting for years," says lead study author Mark Kaminski, M.D., director of the Leukemia/Lymphoma Program and the Multidiscip...Promising treatments for Huntington's disease identified in UCI study
...aid. "They can serve to rapidly identify treatment regimens that are very likely to provide effective therapeu...treats one component of the disease process. These regimens are attractive because lower doses of drugs can be used in order to avoid undesirable side effects c...Antimicrobials to prevent infection in major surgery are used properly only about half the time
...to the study. "However, only 78.7 percent received regimens that were limited to the recommended agents, suggesting that a substantial amount of antimicrobials are used unnecessarily." "The results of this study raise additional concerns regarding antimicrobial resistance. Our data suggest that vancomycin con...Study examines three-day antibiotic regimens for treating bladder infection in women
...s conducted a randomized trial that compared 3-day regimens of amoxicillin-clavulanate and ciprofloxacin for treatment of women with acute uncomplicated cystitis and used follow-up to evaluate the women for recurrent infection. Ciprofloxacin is in the fluoroquinolone class of antibiotics, a potent and freque...Older women can benefit from chemotherapy to treat breast cancer
... alone should not prohibit the use of chemotherapy regimens in older women with breast cancer who are otherwis...ons in breast cancer mortality and recurrence from regimens containing more chemotherapy." "Our study adds to the increasing number of trials that suggest that ...