Research in yeast yields missing link in DNA maintenance machinery
...d a particular protein complex, called INO80, that regulates access to DNA. Inside cells, long strands of DNA are wound tightly around a series of proteins called histones. The combination of DNA and its associated proteins is called chromatin. The histone proteins help compact the DNA and help keep it organiz...Anger, negative emotions may trigger stroke
... response by the sympathetic nervous system, which regulates body functions such as heart rate or blood pressure. The study also examined whether other factors such as positive emotions, heavy physical exertion, and heavy meals were triggers for stroke, and no significant relationship was found. ...Study suggests Akt3 protein is key to melanoma's resistance to chemotherapy
... melanomas. Robertson found that PTEN specifically regulates Akt3. Consequently, when PTEN is lost, Akt3 malfunctions and accumulates, allowing melanoma cells to survive. "In addition to the connection to PTEN, we also found that more copies of the Akt3 gene are present as melanoma cells become more aggressiv...Scientists stalk PPAR-gamma, find novel cancer connection
... Velcade, which targets the parts of the cell that regulates protein expression, Bernstein said. The latest research may offer a third novel approach. The myeloma research emerged from a larger investigation conducted by Phipps' laboratory into inflammation, the culprit of many serious illnesses. One a...Farnesyl transferase inhibitor can help patients at high-risk for developing AML
...zrock says. "It has become apparent that Zarnestra regulates other important cancer genes, although we don't know which ones they are."...System that regulates blood pressure may also affect aging
WINSTON-SALEM, N.C. The same system that regulates blood pressure may also play a role in aging, according to new research from Wake Forest University Baptist Medical Center. Four separate studies point to the renin-angiotensin system, which helps regulate blood pressure, as also being important in ...Ventricular regulation may be key to preventing heart failure
...natriuretic peptides (ANP), a cardiac hormone that regulates blood pressure, are also noted in this experiment. The researchers conclude that "a rise in atrial rate results in an additional increase of circulating ANP, but only in the presence of elevated atrial pressures." ANP levels also rise with atrial p...Researchers discover potential skin cancer prevention target
...We discovered that STAT3 is a unique molecule that regulates critical sets of genes involved in the initiation and promotion of cancer," says DiGiovanni. "Furthermore, we have evidence that if you block the action of STAT3, you get tumors that regress. This makes STAT3 an attractive target for both treatment a...Mixed signals to blame for restless legs syndrome
... TH is phosphorylated, or activated. The active TH regulates the production of dopamine, a substance in the brain that transmits messages from the brain and central nervous system to the body, giving it instructions for normal functioning. Connor's team found that people with RLS have very high levels of activ...Increase in childhood leukaemia may be part due to increased light at night
...n, will be exploring the mechanisms by which light regulates the circadian system. He explains "Embedded within the genes of us, and almost all life on earth, are the instructions for a biological clock that marks the passage of approximately 24 hours. Until we turned our nights into days, and began to travel ...Health benefits of citrus topic at American Chemical Society meeting in Philadelphia
...ibiting a key enzyme, CYP3A4, that metabolizes and regulates certain drugs involved in the grapefruit-drug interaction. The researchers hope that these enzyme-blockers can eventually be developed into a super-pill or specialty grapefruit juice that can be co-administered with prescription drugs to increase the...Duke scientists identify new way to block blood vessels that feed cancer growth
...er cells and provides major insight into how HIF-1 regulates angiogenesis after radiation therapy, he said. "We've known that oxygen levels and blood vessel growth inside tumors are two major influences on how a tumor responds to radiation and chemotherapy," said Dewhirst. "Now we've shown for the first time t...Alzheimer's pathology reduced, longevity improved in mouse model, Gladstone study shows
Removal of an enzyme that regulates the activity of many proteins can suppress key fea... increase or decrease the expression of Fyn, which regulates many other proteins through the attachment of specific groups of atoms known as phosphate groups. Th...New molecule may be basis for drugs that battle overeating and drug dependency
... Connecticut have created a molecule, AM1172, that regulates the processing of a neurotransmitter called anandamide. In tests on mice, Piomelli found AM1172 to be effective in increasing brain anandamide activity, in much the same way as the antidepressant drug Prozac increases activity of the neurotransmitter...New research in atrial fibrillation
...a. (Potassium channels are part of the system that regulates the excitability of the heart.) There are currently potassium channel blockers used to control AF. But, because they affect channels in both the upper and lower (ventricular) chambers of the heart, they can have dangerous side effects and must be car...Computer prescribing systems risk patient safety
... in this week's BMJ. The NHS Information Authority regulates the use of general practice computer systems, but these contain only general references to safety and there is evidence that they do not prevent contraindicated prescribing. Researchers in Edinburgh, Kent and Nottingham tested four computer systems c...Women's health research registry aims to improve women's health for future generations
...es more accurately. The U.S. Food and Drug Agency regulates clinical trials and gives investigators permission to conduct tests under strict regulatory conditions. Some women, Nosakowski says, want to participate in clinical studies because they have a strong family history of a particular disease or condit...New darifenacin data released at the American Urological Association (AUA)
...ction of the detrusor muscle of the bladder, which regulates urination, OAB is characterized by incontinence, urinary urgency and frequency, and nocturia (awakening at night to urinate). According to the American Foundation for Urologic Diseases, at least 16 percent of the population over the age of 40 suffer...Controlling hormones could reduce risk of strokes in younger people
...nsin II, part of an important hormonal system that regulates blood pressure. This is an important mechanism by which these gene abnormalities lead to poor blood supply in CADASIL patients. Angiotensin II, which causes common cardiovascular disorders such as high blood pressure and heart failure, is also abnor...Nitric oxide links bulk of sporadic and familial Parkinson's disease
...enny Chung found that NO is attached to parkin and regulates its activity. But in a mouse model of PD and in patients with PD or a similar condition called diffuse Lewy body disease, NO modification was so high parkin couldn't do its job at all. "We looked at NO modification of parkin step-by-step from the mos...