Salk news: Diabetes first steps
...'s team has discovered that a molecule called CREB regulates fat burning and fat storage in the liver, as well as sugar release. , Short for cAMP Response Element Binding protein, CREB blocks the production of a switch protein, called PPAR-gamma, which normally promotes fat storage. By shutting off the PPAR-ga...Bone marrow stem cells build new circulation to lungs
...l and blood. This lining, called the endothelium, regulates a host of basic processes, such as blood clotting and blood pressure. Our results show that endothelial progenitor cells from the bone marrow circulate in the bloodstream. We can use them to form new blood vessels or repair damaged ones, Stewa...Antidepressants decrease chronic pain by inhibiting TNF production in brain, UB researchers find
... neurons make TNF, we've shown that norepinephrine regulates TNF, and vice versa, suggesting a physiologic role for TNF. These results will provide insight into diseases, including chronic pain, caused by alterations in the levels of TNF or by changes in the regulation of neurotransmitter release from neurons...Protein identified that may play central role in inflammatory bowel disease
...ed here at U.Va. is a cytokine, a key protein that regulates the immune response, that could be an important target for therapy in IBD patients who are not responding to current treatments for ulcerative colitis and Crohn's disease," said Dr. Fabio Cominelli, principal investigator of the study, professor of i...Scientists identify novel enzyme with key role in leukemia protein's normal function
...Jekyll-and-Hyde personality. Normally, the protein regulates when and how body parts develop, but when mutated,... its normal state, the MLL protein switches on and regulates a special set of genes known as HOX genes. This gene set is the master controller of the development...Jefferson and Michigan scientists identify gene defect behind muscle-wasting disease
...ochondria, which generates energy in the cell. Omi regulates apoptosis, or programmed cell death, by binding an...s and to understand at the molecular level how Omi regulates mitochondrial function," he says....Unrestricted metabolic research grant awarded to Beth Israel Deaconess
...eptin. They have demonstrated that leptin not only regulates appetite, but also serves as a regulator of the neuroendocrine axis for reproductive, thyroid and adrenal control. Dr. Flier has created a dynamic team at Beth Israel Deaconess and we are very pleased to add our support to this exciting work." "The u...Emory researchers find Paxil improves memory and brain structure in PTSD sufferers
...associated high levels of cortisol, a hormone that regulates stress, with negative effects on this area of the brain. Studies in animals have also shown that medications such as Paxil have a beneficial effect on the growth and structure of hippocampal neurons. The study participants were all residents of the ...Comfort-food cravings may be body's attempt to put brake on chronic stress
...s of corticotropin releasing factor, which in turn regulates adrenocorticotropin both key inciting hormones in the chronic stress response system. This creates a positive feedback loop between the stress systems of the body and brain. From their studies, the researchers concluded that rats with chronically el...Rush studying the role of intra abdominal fat in coronary artery disease risk in women
...cally at their highest. Cortisol is a steroid that regulates blood pressure and cardiovascular function as well as the body's use of proteins, carbohydrates, and fats. Cortisol secretion increases in response to any stress in the body, whether physical (such as illness, trauma, surgery, or temperature extremes...JCI table of contents, 1 August 2003
...d development of this class of drugs. TITLE: P2Y12 regulates platelet adhesion/activation, thrombus growth, and thrombus stability in injured arteries AUTHOR CONTACT: Pamela B. Conley Millennium Pharmaceuticals, Inc., South San Francisco, California, USA. Phone: 650-244-6839 Fax: 650-244-9208 Email: pconley@m...Emory scientists contribute to study of key regulatory protein in neurodegeneration
...P could be regulated by Pin1," he says. "And Pin1 regulates many proteins, not just tau and APP. This research is really at the crossroads." Dr. Li hypothesizes that Pin1 loss of function could contribute to other neurodegenerative diseases like Parkinson's and Huntington disease....UCSD researchers determine mechanism for degradation of G proteins
...ally target G proteins for degradation and thereby regulates G protein signaling by controlling the amount of G protein expressed in the cell. This occurs via GIPN binding to the N terminus of G alpha interacting proteins (GAIP), which is the mechanism that sets the ubiquitin system in motion. The ubiquitin ...UT Southwestern researchers, Nobel Prize winners share 2003 Albany Medical Center Prize
...ntributions pertaining to how a family of proteins regulates cholesterol synthesis by specifically controlling the low-density lipoprotein (LDL) receptors, which play a key role in cholesterol build-up. "Joe and I are grateful to the committee for selecting us for this honor," said Brown, professor of molecula...Enzyme found in blood vessels likely target to treat lung injury
...e blood from entering tissues and organs. MLCK 210 regulates normal endothelial cell function, but the contribution of MLCK 210 to the mechanisms of lung injury in the living animal was unknown. Wainwright said that cell culture (or, in vitro) studies have identified several enzymes, including MLCK 210, in th...Other highlights of the January 1 JNCI
...und that the phosphatidylinositol 3-kinase pathway regulates nuclear translocation of C/EBPß....U.Va. team identifies gene that could halt spread of cancer
...scu hopes to discover exactly how the RhoGDI2 gene regulates cell metastasis....Pituitary tumor cells in Cushings syndrome found to express large amounts of protein receptor
...hich lowers blood sugar. In fat cells, PPAR-gamma regulates sugar metabolism. In view of the relationship between excess steroid hormones and obesity, the investigators first examined normal human pituitary tissue to determine which pituitary cells expressed PPAR-gamma. Their analysis revealed that PPAR-gam...New drug may reverse bone loss without estrogens side effects, Science study says
...ies. The so-called "genotropic" signaling pathway regulates the expression of genes in the cell nucleus, and it is this pathway that has been linked to cancer development in reproductive tissue. The "non-genotropic" pathway promotes bone growth, by extending the lives of bone-building cells called osteoblasts...People near freeways are exposed to 30 times the concentration of dangerous particles
...S. Environmental Protection Agency (EPA) currently regulates particles less than 2.5 micrometers in diameter, and ultrafines represent the very smallest particles inhaled by the public. Traffic-related air pollution is of great concern to Los Angeles, which has the most severe particle air-quality problem in t...