Tacrolimus Stops Rejection Of Kidney Transplants
...transplant centers. Despite tremendous progress in regulating the immune system, stubborn or "refractory" rejection-an unrelenting immune system assault against the transplanted organ-remains one of the principal problems of organ transplantation. This is the first multi-center trial to demonstrate such encoura...Wistar Scientist Awarded American Cancer Society Grant For Study Of Tumor Suppressor Proteins
...ncers all share acommon characteristic -- the gene regulating the activity of P16INK4, whichfastens itself to the CDK4 inhibitory protein, is either deleted or mutated. The consequence of this genetic alteration is that the P16INK4 protein does notinterfere as it should with tumor growth. "Because of its key ...Effective Obesity Treatment Likely To Require Targeting Of Multiple Weight Control Systems
...y has numerous integrated and redundantsystems for regulating weight, and that many pathways in the central nervoussystem participate in responding to signals informing the brain about the fatcontent of the body. "While the notion of a single 'magic bullet' for obesity treatment isoverly optimistic," sa......te the central and the autonomic nervous system by regulating thesecretion of various hormones into the blood stream. One of the hormones, whichis secreted under acute stress conditions in the hypothalamus, is theneuropeptide corticotropin-releasing hormone (CRH). CRH triggers the release ofthe adrenocorticotro...New "Body-Friendly" Fat Substitute Can Help To Transform
...ts or barley. Beta-glucans may also play a role in regulating blood sugar levels. Studiesconducted by Judith Hallfrisch, Ph.D., and Kay M. Behall, Ph.D., researchers at the ARSHuman Nutrition Research Center in Beltsville, Md., suggest that beta-glucanslower and steady the production of insulin, released by ...Steroids May Reverse Loss Of Substance Tied To Nervous-System Diseases
...the world. "Steroids seem to be very important in regulating the initiationand synthesis," said Michael Glaser, professor of biochemistry andlead investigator of the project. "They had been implicated as havinga role in the overall process, but not for enhancing the actual synthesis. It is our hope that this ...UCSF Study Finds DHEA Benefits Cardiovascular Function
...sure, maintainingthe tone of coronary arteries and regulating blood flow to the heart and otherparts of the body, Zellner said. When ET-1 is elevated the heart's vesselsconstrict, meaning the flow of blood is hampered and the heart's tissue does notget the oxygen and nutrients it needs to perform well and stay ...Insulin Resistance And Obesity Avoided In Genetically Modified Mice, As Reported In Science
...one. PTP-1B also appears to play a role in regulating metabolism, asevidenced by the fact that the knockout mice resisted gaining weight moresuccessfully than the normal mice. However, more work must be done to understandhow this occurs....A Genetic Marker Of Panic Disorder
...onto?s Clarke Institute report a study of thegenes regulating CCK function in 99 patients with panic disorder and age- andsex-matched controls. They found that panic disorder is highly associated to ahighly polymorphic marker on the regulatory region of the CCK-B receptor. Thus,variations in CCK receptor functi...Stress may increase susceptibility to infectious disease
... known as cytokines play in regulating the immuneresponse. In some cases, they stimulate the release of othercompounds essential for inflammation. In other cases, theymaintain the balance of other components of the human...Study reveals how brain controls eating in normal rats
...e known that the hypothalamus played a key role in regulating food intake and body weight. In these classic experiments with rats, lesions in one part of the hypothalamus created massively obese rats. Lesions in another part of the hypothalamus blocked the urge to eat and even caused death by starvation. Howev...UCSF finding could lead to a new class of painkillers
...These results suggest that PKC plays a key role in regulating pain sensitivity," said a senior author of the UCSF paper, Robert Messing, MD, an associate professor of neurology. "The fact that inhibiting PKC reduced pain in response to several different sensitizing agents is significant." Since absence or inhi...Of vasectomies, vitamins and prostate-cancer risk: Hutchinson Center study examines the links
...healthy prostate tissue. Zinc may playsome role in regulating healthy prostate growth. The results for vitamin E oncancer risk were somewhat smaller than the protective effect found in oneprevious study. Overall, Kristal says, the study adds weight to the idea that some supplementalvitamins and minerals may i...Lack of sleep alters hormones, metabolism
...eep deprivation alteredbasic bodily functions such regulating blood-sugar levels, storing away energyfrom food and the production of various hormones. They followed 11 healthy young men for 16 consecutive nights. The first threenights the subjects were allowed to sleep for eight hours, from 11 p.m. to 7a.m. T...Scientists identify new pathway of antidepressant action
...uman brain may play a strong physiological role in regulating anxiety and depression." Lead author on the PNAS paper is Lisa D. Griffin, MD, PhD, assistant professor of neurology at UCSF. Studies by other researchers have shown below-normal brain neurosteroid levels among people with some depressive disorders, ...Researchers discover alcohol-sensitive membrane channel
... distributed in the brain and play a major role in regulating inhibitory responses in the central nervous system. They act by regulatingneuron-to-neuron communication and the rate of this information transfer. Whereas most potassium channels are either unaffected or inhibited by ethanol and other alcohols, GIR...Patients with social phobia benefit from long-term treatment with sertraline HCl
..., among other behaviors. Serotonin is critical in regulating the brain's control of anxiety, depression and aggression. For a person whose serotonin recycling is not balanced, sertraline can increase the availability of serotonin to help the brain regain control, according to Van Ameringen. For this 24-week r...Beyond Viagra: other phosphodiesterase inhibitors are candidates for potential therapies
...nd memory. On the one hand, this means that drugs regulating PDEs may someday provide a treatment for people with vision or memory problems. But at the same time, any researcher wanting to use PDE inhibitors to treat one specific part of the body must make sure that the therapy does not interfere with other PD...Smoking restrictions in restaurants are not bad for business
...about the economic impact of impending legislation regulating employee tobacco use and smoking in restaurants. A...e large firms, numbering 200, already had a policy regulating smoking in place. Over half of large firms without a policy would opt to impose a smoking ban rather...Highest known catalytic rate for superoxide dismutation achieved
...s a central role in the bodys oxidative chemistry, regulating normal levels of free radical superoxide molecules. In certain disease states, however, the bodys immune system prompts an overproduction of superoxide free radicals and the natural SOD enzymes become overwhelmed, leading to tissue and cell damage. ...