MetaPhore Pharmaceuticals initiates Phase I clinical trial of enzyme mimetic compound for oncology
...s a central role in the bodys oxidative chemistry, regulating normal levels of free-radical superoxide molecules. In certain disease states, however, the bodys immune system prompts an overproduction of superoxide free radicals and the natural SOD enzymes become overwhelmed, leading to tissue and cell damage. ...SNM reaction to OMB position on nuclear byproduct materials
...ed his expression of concern "that the benefits of regulating medical uses of byproduct materials may not justify the costs of the Part 35 requirements." Nuclear byproduct materials are used to produce some of the tracer elements injected into patients to conduct many potentially life-saving nuclear medicine pr...Organizations renew professionalism vows
...t, and professional responsibilities, such as regulating members and setting standards. The charter was written by members of the Medical Professionalism Project sponsored by the ABIM Foundation, the ACP-ASIM Foundation and the EFIM. Members of the projects working committee met for several years ...Testicular cancer - cure rates now so high patients may be more at risk from treatment
...imise this risk, such as controlling their weight, regulating their blood pressure and cholesterol levels and not smoking." Norwegian researchers lead by Dr Sophie Fossa from the Norwegian Radium Hospital, Montebello, Oslo, evaluated renal function in 85 former patients diagnosed between 1984 and 1988. There we...UCSD team reviews pituitary gland development, from a common primordium to distinct cell types
...ternal environment). The gland is a complex organ regulating a combination of neural signals from the hypothalamus as well as feedback from target organs. In recent years, researchers have begun to identify some of the molecules that direct the series of developmental steps by which precursor cells gain a pitu...Fatty acid from fish oil fights arrhythmias, sudden death
...own that the fatty acids play an important role in regulating the electrical activity of heart muscle cells. They stabilize these cells so they are very resistant to arrhythmias, he says. Leaf also notes that these findings support a theory that an imbalance of n-3 PUFA and fatty acids called n-6 PUFA promote ...A caring mother is a childs best defence against drug culture
...ilies but especially the unique role of mothers in regulating the behaviour of the great majority of young people. Dr McArdle and his colleagues analysed the answers to questionnaires filled in by 3,984 youngsters, aged 14-15, selected at random from cities in England, Eire, Italy, Germany and the Netherlands....Memory isn't 'lost,' just out of sync
.... Then we want to see if we can treat patients by regulating this disrupted memory circuit," Dr. Hart explained....Continued disruption of movement among alcoholics despite abstinence
...re damaged by chronic alcoholism are important for regulating smooth movement of the arms and legs," said Sullivan. "Selective damage of these structures can cause jerky and somewhat dyscoordinated movement. Thus, even when an alcoholic becomes sober, 'ataxia of movement' or instability and compromised moveme...The current status of elder abuse in the United States
...ness and uniformity. There are no federal statutes regulating the delivery of Adult Protective Services, and there is no federal agency charged with responsibility to collect data and issue reports. Mary Joy Quinn, RN, MA, of the Civic Center Courthouse in San Francisco and Candace J. Heisler, JD, a retired San...Proposals to regulate cosmetic surgery will not protect the public
Government proposals for regulating cosmetic surgery in the United Kingdom would permit unqualified surgeons to remain in practice, according to an editorial in this weeks BMJ. The proposals demand only that surgeons be medically qualified and have attended some postgraduate courses, d...Dopamine may play role in cue-induced craving distinct from its role regulating reward effects
... food motivation that is distinct from its role in regulating food's reward effects through the nucleus accumbens. Previous research has linked increases in dopamine in thenucleus accumbens, the reward center of the brain, with addiction. WHAT IT MEANS: The finding that dopamine may play a role in cue-induced e...Hypertension is study focus of $10 million NIH grant to MCG
...entists studying the body's natural mechanisms for regulating blood pressure. The grant makes it possible to fur...e. One way the body increases blood pressure is by regulating sodium retention and Dr. Harshfield has found that some healthy blacks have an impaired ability to e...Common diabetes drug causes arteries to spasm, endangering heart
...on the smooth muscle cells that surround arteries, regulating flow through these vessels. The researchers found that mice without the receptor, had no functional potassium channels in their smooth muscle, leading to calcium influx and contraction of the smooth muscle cells that surround arteries.. Drugs that...Platelet molecule regulates blood coagulation, study finds
...ne PS can be thought of as a "second messenger" in regulating blood coagulation. Thus, in the ever-ongoing stream of cell signaling, activation of platelets when a wound occurs triggers exposure of PS on the platelet membrane surface, which Lentz's work shows regulates the key event of the coagulation process,...Drug targets brain circuits that drive appetite and body weight
...nin directly and signal to regions associated with regulating energy. "Our study has linked the serotonin system, a classic brain pathway thought to be involved with eating disorders like anorexia nervosa, to the melanocortin system, a brain pathway involved in obesity," explained the study's senior author, Jo...Researchers identify brain pathway to explain how Fenfluramine causes weight loss
...tin that act on the brain's melanocortin neurons, regulating food intake and body weight," explains the study's senior author Joel Elmquist, D.V.M., Ph.D., a neuroscientist and endocrinologist at BIDMC and associate professor of endocrinology and medicine at Harvard Medical School. The diet drug d-FEN, which i...Study pinpoints link between sleep apnea, high blood pressure
...y found that changes in the expression of proteins regulating a potent natural vasodilator in the kidney mirrored changes in blood pressure of the kidney. The process appears to play a significant role in the development of high blood pressure during bouts of sleep apnea, concluded researchers Jon Klein and Dav...Researchers find gene that causes leukemia in children with Down syndrome
...mplete protein appears to be far less effective in regulating target genes, resulting in an outcome that is similar to having no GATA1 protein at all. "GATA1 is just part of the story," said Crispino, "but it is a crucial early step that should lead us to the rest of the pathway." The authors suspect that it r......ion of gene expression). "This novel strategy for regulating the anticarcinogenic activity of retinoic acid has...ompounds known as retinoids that play key roles in regulating gene transcription and, therefore, govern multiple functions in the body, such as cell division and ...