Mayo Clinic researchers discover how key cancer protein works
...nsely investigating. Their question is: How do the regulating mechanisms of the "cell-cycle" work? The cell cycle is the complex, natural -- and normally orderly -- process by which cells reproduce. The Mayo Clinic research reveals the details of a molecular mechanism involved in cell cycle regulation of a gene...High levels of immune protein in infant brain linked to SIDS
...various cytokines (a class of proteins involved in regulating the immune system) in the brains of each group. All 19 SIDS brains showed strong or moderate levels of interleukin-1 (a type of cytokine) in the same regions of the brain stem. Six of the non-SIDS brains had weak, negligible or no level of interleuki...Leading the way in novel anti-cancer research
...kinases : The Aurora kinase family is important in regulating mitosis and cell division. Because these kinases are only expressed in cells that are actively dividing, they could be an important new target in cancer. Aurora kinases are commonly over expressed in breast, colon, pancreas and bladder tumors and thi...Experimental drugs show promise in halting brain tumors
...r cells called mTOR. This protein is essential for regulating a cell's metabolism. Without it, cells cannot produce adequate levels of protein to carry out cellular functions, and thus the cells do not grow properly. The combination of these two drugs inhibited tumor growth more significantly than either drug a...Faulty wiring in the brain may cause early-onset schizophrenia
...ntal lobe that disrupt the transmission of signals regulating behavior, according to a study presented today at the 89th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA). "Until now there's been no sophisticated method of finding abnormalities in the white matter of the...Major cause of painful gastroenteritis under study at MCG
...e bit about." Body temperature, which is a cue for regulating some proteins, is one factor he's exploring. Chickens which are the main hosts for Campylobacter yet are unaffected by the infection have a higher internal temperature than people. "We are in the process of identifying proteins that are turned on i...Anti-eosinophil therapy shown to be effective in treating hypereosinophilic syndrome
... (IL-5). IL-5 is a cytokine critically involved in regulating several aspects of eosinophils including their production, activation and tissue recruitment. Four patients, previously dependent on a variety of toxic medications to partially treat their hypereosinophilic syndrome, were given three intravenous do...Optic nerve disease may cause sleep disorders
...ldren with optic nerve disease might have problems regulating their internal body clocks. To measure the impact of the loss of those cells, first author Raymond Wee, a graduate student in Van Gelder's laboratory, had participants wear a device known as a wrist-worn actigraph. Worn like a watch, the actigraph me...New breast pap smear detects early cellular changes; May prevent onset of breast cancer
...is present inside cells, vitamin A can do its job: regulating how breast epithelial cells grow, divide and event...enes -- CBP and p300 -- which are also critical in regulating how a cell grows. One key to reversing the methylation of RAR beta could lie in vitamin A and substa...Metabolic 'footprint' may be new measure of obesity risk in kids
...and higher levels of leptin, a protein involved in regulating weight. The adiponectin level in normal-weight children averaged 30.4 micrograms per milliliter of blood (g/ml) and 21.6 g/ml in obese children. Leptin levels averaged 37.6 nanograms permilliliter (ng/ml) in obese children and 8.5 ng/ml in normal-w...Data shows new drug, rimonabant, helps smokers quit while limiting post cessation weight gain
... other parts of the body. Associated with systems regulating the body's intake of food, the EC system is also involved in tobacco dependency. Chronic tobacco use over-stimulates the EC system creating an imbalance. By blocking the CB1 receptor, rimonabant helps restore balance to the EC system resulting in r...ERI patents treatments for insulin resistance in diabetes accompanying obesity
...am. Brennan and Hochgeschwender instead focused on regulating insulin resistance in genetically engineered mice by manipulating the amount of MSH in the bloodstream. "It's a whole new way of looking at diabetes," says Brennan. "People have been working on diabetes for years, and this is an entirely unexpected...Unraveling the secrets of the brain's smallest cells
... US, and dysmetria, where patients have difficulty regulating the rate, range and force of movement. The group also found that the activity of granule cells is kept in check by a 'tonic inhibition' mechanism. There is growing evidence that alcohol can boost this inhibition and thus affect cerebellar function, ...Researchers identify cancer-causing gene involved in aggressive leukemia, lymphoma
...ay alter the expression of those genes involved in regulating cell growth, in turn leading to cancerous transformations. "We believe the transgenic mouse used in this study will also provide a valuable tool for determining how overexpression of the HMG-I gene leads to cancer cell growth and for identifying new ...UCI Tobacco research center reports why teens are most vulnerable to smoking addiction
... in the brain occur, including those involved with regulating the effects of drugs and other stimuli. The Transdisciplinary Tobacco Use Research Center at UCI is one of seven centers in the United States established to study the factors involved with one of the nation's health crises: teen smoking. Part of its...Use of cameras to monitor nursing-home care is subject of controversy
...er at night knowing that the independent source is regulating and reviewing the tapes should any problems arise," Cottle wrote. "This service, like the cost of the cameras or of the tapes, is an added institutional cost that the nursing home will incur. Nevertheless, it is likely the best ...UW to lead most comprehensive study of air pollution and cardiovascular disease
...really form a strong enough scientific basis to be regulating against pollution. This study is designed to answer those questions," Kaufman said. The study will be based at the UW in Seattle, and will include faculty from the UW departments of Environmental and Occupational Health Sciences, Biostatistics and E...Molecular clock genes influence metabolism of sugar and dietary fats
... the circadian clock proteins, Bmal1 and Clock, in regulating the day-to-day levels of glucose in the blood. Sup...pothalamus. Many of our basic functions, including regulating body temperature and hormone levels, vary throughout the day and night. Some of these changes may re...Marine sponge leads researchers to immune system regulator
...t a sugary lipid known as iGb3 plays a key role in regulating the response of natural killer T cells, a componen...portant, although still poorly understood, role in regulating all sorts of immune responses. Defects in the system may allow the body to attack itself, leading t......e next step will be to study the role of nAChRs in regulating the behavioral and cellular responses to antidepressants. They will see if there is a direct effect mediated by nAChRs or an indirect effect of modulating neurotransmission in other cell types. "Use of more specific nAChRs antagonists, both alone and...