Innovation attracts new research funding
...d the processes underlying chronic and acute organ rejection and to improve long-term organ survival. Max Buch...erapeutic advances, today, the risk of acute organ rejection following transplantation can be as low as 10%. About ROTRF Roche Organ Transplantation Research F...Pitt receives $14.5 million from NIH to improve pediatric heart transplantation outcomes
...ntation. Nearly every patient faces bouts of acute rejection and some sort of immunosuppressive drug-related co...ic injections indicated significantly fewer "late" rejection episodes and less immunosuppression requirements one to five years after the procedure compared to 2...Kidney transplant patients who develop diabetes show poor short-term outcomes
... drug therapies taken to help patients avoid organ rejection can actually cause patients to develop diabetes. Limited data form other studies also has suggested that post-transplant diabetes is associated with higher rates of long-term sickness and death primarily due to an increase in infections or heart and ...U of M researchers a step further in Type 1 diabetes treatment
...blood cells that cause Type 1 diabetes and mediate rejection of transplants. Study participants received two other immunosuppression drugs. In a subsequent trial supported by the NIH Immune Tolerance Network ( www.immunetolerance.org ), the research team at the University of Minnesota and UCSF will test wh...NIH researchers test promising new therapy for blinding eye disease
...nd Drug Administration for use in preventing organ rejection in patients receiving kidney transplants, daclizumab's safety profile is already well characterized. These factors paved the way for FDA approval to begin the present clinical trial. Dr. Thomas Waldmann, a co-author of the current study and chief ...Univ. of Pittsburgh to lead international trial for vocal cord paralysis and paresis
... being reabsorbed and other materials triggering a rejection response to the material. It is hoped that the CaHA injection material will be an improvement over presently available substances." In vocal cord disorders such as paralysis, atrophy and paresis, one or both vocal cords are weakened and lack the abi...Study finds lesbian and bisexual girls are at heightened risk for tobacco use
...in public health. "Antigay stigma and harassment, rejection from family, friends, peers and sometimes even physical violence can create a hostile environment for many young people coming to terms with their sexual orientation. This combined with the tobacco industry's targeted marketing to lesbian and gay co...Improving the chances of successful organ transplants
...ue type between donor and recipient that can cause rejection of the donor organ by the recipient's immune system. If this rejection reaction is not successfully treated through the administration of immunosuppressive drugs, the dono...Heart transplant survival: Results may be key to rejection prevention, detection, treatment
...erolimus used to prevent acute cardiac disease and rejection 24-month study results (Abstract #28) Using mol...use of death during the first three years is acute rejection of the transplanted organ. The patient's immune system attacks the heart as if it were a foreign obj...Mycophenolate mofetil superior to azathioprine: Slows vascular disease progression after transplant
...pt (mycophenolate mofetil), a drug used to prevent rejection in organ transplantation, have significantly lower progression of intimal thickening, or thickening of the inner artery walls, compared with azathioprine (AZA). Intimal thickening is becoming increasingly important as a surrogate marker for long-term...CellCept's cardioprotective profile reinforced
...mmunosuppression used in patients at risk of organ rejection following kidney transplant. CellCept has also been approved for prevention of rejection in heart, liver and paediatric kidney transplant in 1998, 2000 and 2001 respectively. Over this time...Insights from intravascular ultrasound explore treatment benefits
...sculopathy, and its concomitant reduction in acute rejection rates, is maintained through 24 months. In this 634-patient study conducted in 54 centers worldwide, prospective analysis of the IVUS-population (matched analysis, n=149) was performed. This study, using rigorous IVUS techniques, revealed that the ...New drug is safer and more effective in preventing heart tranplant rejection
Although cyclosporine is widely used to prevent rejection in organ transplant recipients over the long term,...orine and steroids, everolimus prevents transplant rejection and lowers risk of infection and other complications better than the current standard anti-rejection...Data announced at ISHLT: Molecular testing proves effective in monitoring heart transplant rejection
...es the patient's immune response enough to prevent rejection of the transplanted organ, but not so much that th...e quiescent state and predict future occurrence of rejection during the first year after cardiac transplantation. "The development of alternative, no...Mothers' cells can cause immunity illness in children
...o. Because of this resemblance to a type of organ rejection disease, the Mayo Clinic team investigated the idea that "non-self" or chemeric cells may play a role in initiating JDM. The Mayo Clinic researchers discovered two new aspects of chimeric cells. First, they remain in the offspring after birth an...CellCept associated with reduced incidence of cancer, compared to AZA, following heart transplant
...sporine and corticosteroids) for the prevention of rejection in patients receiving heart, kidney and liver tran... received FDA approval for the prevention of organ rejection in kidney (May 1995), heart (February 1998), and liver (July 2000). The recommended dosages for Cell...Tacrolimus + mycophenolate mofetil & steroids: Safe, effective in preventing acute cardiac rejection
...est and most effective in preventing acute cardiac rejection the most common cause of mortality in the first y...lling 343 patients was to compare any incidence of rejection requiring treatment in the three triple-therapy regimens. Secondary objectives were to compare in ea...Bone implants could aid healing after tooth removal
... own tissue. It also eliminates the risk of tissue rejection and disease transfer from donor grafts, and it requires no additional surgery to harvest grafts from the patient. "The development of a method for healing critical-size defects in the bone of the jaw would benefit not only those who have teeth pul...Study shows heart biopsy possible via arm catheterization
...lant patients so physicians can check for signs of rejection of the transplanted heart. Heart biopsies also are used to diagnose the cause of a patient's heart failure, or to check the hearts of some patients who are being treated with chemotherapy. Originally, surgeons would do heart biopsies through a large ...University of Pittsburgh approach has lung recipients taking far fewer drugs
...ard the donor organ from immune system attack. But rejection plagues these patients more often and more vigorou...ore broadly and for a longer period of time. Acute rejection episodes have been less in the Campath patients reported on at ATC compared to those who received Th...