Discarded Treatment For Heart Attacks May Yet Prove To Be A Life-Saver
...K II International Study, each patientwill undergo reperfusion therapy and none will receive the drug more than 12hours after the onset of symptoms. It is scheduled to conclude in 2001. "We are expecting a reduction in death of about 15 or 20 percent amongpatients treated with GIK," Diaz says. "Nobody c...Extract from traditional Chinese herb enhances recovery in stressed cells
...ly great start,"says Vanden Hoek. Cell death after reperfusion of oxygen and sugar decreased from 47 percent inuntreated cells to 26 percent in cells receiving the baicalensis extract. "Though this extract is far from human trials, this paves the way for developingnew therapies for cardiac arrest as well as oth......ally reduced tissue damage due to inflammation and reperfusion the latter involving the return of blood flow to a surgical site following a surgical procedure. These results provided a scientific rationale for an entirely new class of molecules based on the mimic of SOD to treat inflammation, pain, shock, arth...NIH awards grant to MetaPhore Pharmaceuticals to study novel pain treatments
...ally reduced tissue damage due to inflammation and reperfusion - the latter involving the return of blood flow to an organ following removal of a blockage, such as after a heart attack. A study published in the Proceedings of the National Academy of Sciences in August 2000 indicated potential new treatments to c...FDA awards grant to metaphore pharmaceuticals to study septic shock in humans
...ally reduced tissue damage due to inflammation and reperfusion the latter involving the return of blood flow to an organ following removal of a blockage, such as after a heart attack. MetaPhore recently announced that it has received an SBIR grant from the National Institutes of Health (NIH) to conduct Phase ...Heart attack help: Program helps boost use of key therapies in hospitals
...e ER and at discharge, clot-busting drugs known as reperfusion therapy in the ER, measurements of blood cholesterol and the pumping capacity of the heart's left ventricle, catheterization or heart imaging studies in certain patients, selected angioplasty or bypass surgery, and use of beta blockers and ACE inhibi...Animal studies indicate new approach for treating end-stage skin and kidney cancers
...ncer, complications of diabetes mellitus, strokes, reperfusion injury, as well as pain and inflammation.One of th...ally reduces tissue damage due to inflammation and reperfusion injury the latter involving the return of blood flow following removal of blockade, such as after a...Highest known catalytic rate for superoxide dismutation achieved
..., exhibited protective effects in animal models of reperfusion injury and septic shock at dosage levels one hundr...ncer, complications of diabetes mellitus, strokes, reperfusion injury, as well as pain and inflammation. One of the bodys primary defense mechanisms against free-...COOL AID safe after stroke, may deter side effect of clot-busters
...ring blood flow causes more tissue damage known as reperfusion injury. This injury occurs when the rush of resto...and inflammatory responses known to play a role in reperfusion injury. The goal of this pilot study was to provide brain protection to patients at high risk of de...International study highlights underuse of reperfusion therapy for heart-attack patients
...ts with a severe heart attack may not be receiving reperfusion therapy, despite the well-known benefits of this t...in this weeks issue of THE LANCET. The benefits of reperfusion therapy- the use of fibrinolytic agents and/or coronary angioplasty to restore coronary artery blood...Light-weight heparin has heavy-weight results in heart attack treatment
...articipants were randomly assigned either standard reperfusion with a full dose of the clot-dissolving drug tenec...arin as adjunctive treatment with various forms of reperfusion therapies (TNK, abciximab). To evaluate reperfusion (blood flow) researchers used the TIMI grading ...Experts recommend increased funding, focus on resuscitation science
...animals tolerate ischemia (loss of blood flow) and reperfusion (restoration of blood flow) without injury and therefore represent a potentially valuable model for studying ways to improve outcomes from ischemic injury, researchers say. Based on experience in animal studies, the heart rate decreases to as littl...Trial opens new possibilities for improving survival with a novel heart attack drug
... return of oxygen-rich blood, a condition known as reperfusion injury. To date, no effective therapy has been discovered to reduce or stop the damage of reperfusion injury. According to Granger, while the mechanisms of this reperfusion injury are poorly understood,...Drug combination opens clogged arteries faster, keeps them open longer
...ndomized trials to better understand if this early reperfusion has any effect on outcome," Roe said. A Phase II I trial dubbed ADVANCE-MI, being led by Duke cardiologists, is currently under way to answer these questions. The INTEGRITI trial was funded by Millennium Pharmaceuticals, Cambridge, Mass., and Scherin...Angioplasty clears clogged brain arteries
... occurred in the periprocedural period, one due to reperfusion hemorrhage and one due to vessel perforation. Follow-up was available in 34 patients and varied between four and 128 months (average follow-up 53 months) with 29 patients (or 85.3 percent) having greater than 24 months follow-up. The annual stroke ...Zengen's new study reviews novel approach to control inflammation using melanocortin receptors
...europathies, systemic host reactions, ischemia and reperfusion injury and infections. "The study results also indicate that certain melanocortin peptides have antimicrobial effects," said James Lipton, Ph.D., chief scientific officer and director of Zengen and study author. "Unlike corticosteroids, melanocort...State-required continuing medical education does not affect heart attack care
...s, the researchers examined the use of aspirin and reperfusion therapies (such as thrombolytics) on admission, as...ity rates, he continued. "However, the rate of reperfusion therapy at admission was significantly higher -- 53.1 percent -- in states requiring CME when compar...Heart attack deaths increase during winter holidays
...ficant difference in the adjusted rates of overall reperfusion strategies, suggesting that the decreased use of angioplasty was not recognition of the need for reperfusion, but perhaps an inability to utilize the catheterization laboratory during holiday down times." Meine pointed out that the database they used...Emory researchers find race and gender gaps in treatment of heart attack
...mended treatments and procedures for MI (including reperfusion therapy, aspirin, beta blockers, and coronary angi...dy. Gender and racial differences were greater for reperfusion therapy, coronary angiography and coronary artery bypass graph (CABG) surgery than for other MI trea...Duration of hospital stay has shortened for patients with heart attack
...gement of AMI, including increased use of coronary reperfusion modalities [techniques to restore blood and oxygen flow to the heart muscle]," write the researchers....