Tag: "replication" at medical news

Researchers Synthesize Compounds For New Class Of Antibiotics

...ronin A and B, two naturalcompounds known to block replication of drug-resistant strains of bacteria.Before this breakthrough, the compounds could only be isolated from theirbacterial source, a process that yielded quantities too small to be usable. From a therapeutic standpoint, the compounds look parti...

International Panel Evaluates Testing For Drug Resistance In HIV

...regimensthat have the best chance of keeping viral replication at an undetectable level. Two types of resistance assays are currently available: genotypic assays thatlook for known resistance-associated genetic mutations, and phenotypic assaysthat directly measure whether a particular drug will kill a sample o...

Promising Results For Woman-Controlled Anti-HIV Product

...n how the genital tract can have highlevels of HIV replication even when the virus is not readily detected in theblood. Media Contacts: Kenneth Mayer 401-729-2776 kenneth_mayer@brown.edu...

UCSF AIDS Expert Warns Against Early Treatment For HIV Infection

...al strategy that concern Levy include: If virus replication takes place, mutations might develop that could le...hat mutations occurring at a steadyrate during HIV replication are random and would not select for virusesresistant to current drugs. Instead, he adds, it is the ...

Study Shows Efavirenz Promising In Treating Pediatric HIV Infection: Leads To Approval Of New Drug For Testing HIV-Infected Children

...her antiretrovirals, suppressed HIV replication over a 20-week period in most children. "This study demonstrates that efavirenz used in combination with other antiretrovirals can have potent antiviral effects in children,...

WFU And IntraVec To Develop Innovative Cancer And HIV Treatments

...V infection ofcells, rather than on inhibiting HIV replication in already-infected cells, asdoes most current treatment. Also, he said, the new technology is less likelythan current drug therapies to have toxic side effects and generatedrug-resistant HIV mutants. Recent data indicate that the lifetime tr...

Fred Hutchinson Cancer Research Center And Targeted Genetics Corp. Publish Data On Adoptive Immunotherapy For HIV

...can migrate to lymph nodes, themajor site of HIV-1 replication - and that this is associated with greatercytotoxi...f we can provide levels of CTLs that control viral replication for a period ofweeks to months, this may markedly extend the ability of antiviral drugs toHIV-1 to c...

New Vaccine Provides Protection From HIV In Monkeys

...nt of a vaccine capable of seriouslyreducing viral replication and thus stemming the transmission of AIDS," says Dr.Robinson. Challenges For Finding An AIDS Vaccine Most scientists believe an AIDS vaccine will be completely effective only if itinvolves both components of the immune response: humoral and cellular...

Newly Updated HIV Treatment Guidelines For Adults And Adolescents Available On The World Wide Web

...3TC have shown that thiscombination suppresses HIV replication and boosts CD4+ T-cell counts to a degreecomparabl...abacavir+AZT+3TCregimen to adequately suppress HIV replication in individuals with high baselinelevels of plasma viral load," says John G. Bartlett, M.D., chief of...

UCSF researchers report new risk factors for non-Hodgkin's lymphoma

...ne system.Macrophages stimulate the production and replication of B cells by driving Tcell activation. Therefore,...n of macrophages and, therefore, theproduction and replication of B cells. Normally, macrophages become activatedupon ingestion of fat and cholesterol. Like NSAIDS...

Some HIV patients show no viral rebound after stopping drugs

...aking antiviral drugs yetcontinued to suppress HIV replication may have somehow boosted their immuneresponse against the virus by temporary therapy interruptions, researchers fromthe Aaron Diamond AIDS Research Center at Rockefeller University report. Although scientists strongly advise against halting drug ther...

New data provide further evidence of effectiveness of targeted delivery of Relenza and efficacy in both A&B strains

...nued anti-viral activity at the major site ofviral replication and were retained up to 24 hours after a single 10mg inhaleddose. These data strongly support the use of an inhaled therapy that deliversits effect direct to the site of major viral replication. A further benefit of the high concentrations achieved ...

New model suggests that AIDS drugs may not abolish HIV infection

...due tothe rapid but incomplete inhibition of viral replication by anti-HIV drugs. Over time, the rate of HIV decline decreases substantially for a variety ofreasons. These include a progressively increasing proportion of drug-resistantHIV particles as the overall viral load decreases, and a non-uniformdistribut...

A new ion channel involved in cell proliferation: evidence for its oncogenic potential

...ent for division is appropriate, and every step of replication of the cell isfollowed by checkpoints that determine if it has been successfully completed. Under normal conditions, an alteration detected at any of these checkpointsresults in the immediate destruction of the cell (see Figure 1) Such a complexmecha...

Despite the best available anti-aids drugs, Jefferson scientists detect active HIV in the bloodstream

...n's Center for Human Virology. "There had not been replication previously detectable in the bloodstream or in gen...e the virus," he says. "We need to be able to stop replication before we think about eradication." Dr. Pomerantz calls for better detection methods as well. "In...

Study links one human gene to multiple diseases of old age

...ted more than 40 genes known to be involved in DNA replication and cell division, thus immediately arresting cell growth. At the same time, p21 increased the activity of about 50 other genes. Unexpectedly, the researchers said, about 20 of these turned out to be genes manufacturing proteins secreted by t...

Purdue 'stealth compounds' attack cancer cells

...ical wrench into the cell's machinery to block the replication of viruses and cancer cells. "Nucleotides can be used in a number of ways to inhibit a specific critical pathway that a cell requires to proliferate," Borch says. "The problem was, we couldn't deliver nucleotides directly into a cell because they c...

UI-led study shows experimental anti-cancer drug also has anti-HIV properties

... a drug manufactured by Aventis Inc., blocks HIV-1 replication in cell culture experiments. These findings appeared in the July 21 online issue of the Journal of Biological Chemistry. Flavopiridol strongly hinders the cellular process known as transcription, a multi-step process which results in the production o...

Researchers battle drug-resistant HIV on promising new ground

...at inhibition of this vital process will block the replication of the virus, thereby arresting the disease," Pandey said. "These results suggest that [this treatment] may be a potentially attractive therapy." The researchers bonded a synthetic form of DNA - called PNA [polyamide nucleic acid] - to the virus's ge...

Virco first to introduce drug-specific biological cut-offs for its HIV resistance tests

...terms of how much drug was required to inhibit the replication of the virus by 50% (the IC50), and then, compared to the IC50 for a laboratory standard reference virus. By repeatedly running a test with the standard reference virus, the reproducibility of the test was measured and a cut-off was set at this leve...

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