Treatment guidelines for HIV infection announced by international panel of AIDS experts
...ilure remains an important clinical issue. Viruses resistant to an increasing number of drugs raise challenges, both for the clinicians who need to design alternative regimens active on such viruses using their expertise as well as results from virus resistance testing, and for new drug discovery. Several new...Eficiency, feasibility of antiretroviral therapy in Africa demonstrated in IRD-coordinated surveys
... Africa might prompt the large-scale appearance of resistant strains of HIV. A unit has been set up to monitor instances of resistance, with the support of the French National Agency for Aids Research ANRS, by the IRD jointly with several African laboratories including that of Professor Mboup in Dakar. The IRD...Infant mortality rate drops, children more likely to have working parent, be read to
...man Development. "Infant mortality is a stubborn, resistant problem, so even a slight decline is a victory." Dr. Alexander noted that Healthy People 2000, a series of national health objectives published by the U.S. Department of Health and Human Services, set a goal for reducing the infant mortality rate to...Researchers discover shift in organisms causing early-onset sepsis in low-birth-weight infants
... g). Eighty-five percent of the E.coli cases were resistant to ampicillin. Although there were no significant differences in the rates of early infection between infants whose mothers received antibiotics during labor and delivery and those who did not, mothers of infants with ampicillin-resistant E. coli in...Dual action drug fights heart failure
...ortunately, patients with heart failure seem to be resistant to this potential side effect of the drug. This was a very gratifying finding."...Brain tumor therapy needs longer treatment time
...cal trials, the invading cell clusters have proved resistant to treatment, taking up less BPA than their counterparts in the main tumor mass. The new research indicates that with a longer drug infusion time, the BPA levels in the invading cells could come closer to those in the main tumor mass. Other authors ...UCSD study shows increased transmission of drug-resistant HIV infection
... United States carry strains of the virus that are resistant to drug therapy. In the current New England Journal of Medicine article, Little, Richman and their team said that "increases in the prevalence of drug-resistant virus among patients with established HIV infection may be associated with more frequen...Women with PCOS and their siblings with hormone problems have same gene defect
...esistance, while the other 25 percent were insulin resistant but showed no PCOS symptoms and had normal menstrual periods. The PCOS sisters and those with high androgen levels were more obese than unaffected sisters. The PCOS brothers also had significantly elevated levels of the androgen DHEAS, which cor...Potent experimental drug shown to slow the growth of breast and prostate cancer tumors in mice
... HER-2/neu and in prostate cancer tumors that were resistant to treatment with hormone blocking drugs. In ...stosterone to grow or was the type that had become resistant to treatment and now grew independently of testosterone. In the prostate tumors that grew independe...Reducing side effects of retinoic acid cancer treatment
...toxic. Moreover, cancer patients frequently become resistant to RA therapy over time. Noy decided to take a different approach by seeking to understand how the gene-transcription activity of RA is regulated by two proteins called cellular retinoic acid-binding proteins (CRABP-I and CRABP-II). These proteins we...Making cancer cells susceptible to therapeutic attack
...py or radiation, typically tumor cells become more resistant later on, when the cancer recurs or metastasizes. ...aking, physicians may one day be able to alter the resistant malignant tissue itself, making it vulnerable to therapy. "E1A is helping us identify the set of cel...Blocking pathway overcomes tumor vessel resistance to radiation
...ger a chemical pathway that makes the vessels more resistant to therapy. "We know that if vascular endothelium...on Oncology. "However, the blood vessels are often resistant to the therapy. Our initial hypothesis was that the cell survival pathways that allowed the blood ve...Drug improves survival in primary pulmonary hypertension patients
...the smaller blood vessels in the lungs become more resistant to blood flow, the heart's right ventricle must work harder to pump enough blood through the lungs. Epoprostenol is marketed in the United States as Flolan by Glaxo-Smith-Kline and is also known as PGI 2. It works by relaxing blood vessels, thereby...Virus that can infect both mice and humans is driven to extinction with cancer drug
...cate and mutate so quickly, viruses rapidly become resistant to individual anti-viral drugs. Thus, the effectiveness of these drugs is very limited. Now, researchers currently at Cedars-Sinai Medical Center, and the Universidad Autonoma de Madrid, in Spain, report that treating a common virus with a mutation-c...Futile cycle both fights diabetes and causes weight gain
...cerning type II diabetes: how cells become insulin resistant and how TZDs cause them to lose resistance to insulin. By studying how the drug works, the researchers have uncovered a fundamental clue that may allow the development of better therapies "Right now, our findings suggest that weight gain is an inhere...Stanford researcher to find cure for widespread Celiac disease
...Sprue patients. This gluten fragment is unusually resistant to breakdown by digestive enzymes in the intestine, where it remains intact to have a destructive effect on the intestinal lining. Using this information, they identified a bacterial enzyme (a peptidase) that can rapidly degrade this and other relat...'Glutaid' on the horizon? Study may someday spell relief for people on gluten-free diets
...tact throughout these experiments, and also proved resistant to digestion in live rats. The peptide was also readily modified by tissue transglutaminase, the authors found, and the resulting product was a potent stimulant of inflammatory T cells isolated from small intestines of celiacs. Although other pepti...Cipro, related antibiotics over-prescribed, fueling microbe resistance
...seudomonas aeurginosa has become dramatically more resistant to these drugs. The drugs were 95 percent effective in 1992, and now that effectiveness has dropped to about 62 percent....GlaxoSmithKline Drug Discovery and Development Award 2002
...ge between the sugar analog and the purine base is resistant to stomach acid and purine nucleoside phosphorylase," said Dr. Sartorelli, the Alfred Gilman professor of pharmacology at Yale University School of Medicine. "Hopefully these agents will lead to new drugs that will be more potent and effective at in......d more challenging as the malaria parasite becomes resistant to drugs and as the mosquito that transmits the parasite develops insecticide resistance. In many countries where mosquitoes can breed in every rain-filled leaf and people can expect up to 500 infectious mosquito bites in a year, traditional means o...