Making cancer cells susceptible to therapeutic attack
...nse occurs when E1A gene products bind to cellular retinoblastoma proteins -- proteins that normally regulate a cell's life cycle. The finding suggests that the E1A gene renders malignant cells susceptible to attack not by interfering with their physiological functioning, but by preventing their use of normal cellu...Smart virus eliminates brain cancer in animal experiments
...gliomas as well as in many other solid tumors the retinoblastoma (Rb) protein. Found in all cells of the body, an Rb protein acts like a brake on cell division by preventing certain other regulatory proteins from triggering DNA replication. If the Rb protein is missing or non-functioning, a cell can replicate itse...MGH researchers find way of regenerating cells key to hearing
... The activity of certain genes suggested that the retinoblastoma (Rb) protein, known to suppress the cell cycle, could be important for halting the cell cycle in hair cells. To follow up that observation, the researchers used a genetically modified mouse strain in which Rb was no longer made in the inner ear. ...International gathering of experts to share retinoblastoma breakthroughs
Experts in the fields of retinoblastoma research and treatment will gather to update colle...curs at a time of great excitement in the field of retinoblastoma studies, according to Michael A. Dyer, Ph.D., assistant member of St. Jude Developmental Neurobiolog...