Other highlights in the October 2 issue of JNCI
...n and either PI3K or MAPK led to a nearly complete reversal of cancer cells to cells that appear normal, or to cell death....$12 Million SPORE grant spurs head and neck cancer research
...EGF receptors for chemoprevention; p53 therapy for reversal of pre-malignancies of the oral cavity; and apoptosis or cell death. Since 1992, the National Cancer Institute has awarded SPORE grants into certain cancer sites for concentrated research that focuses on projects with a translational emphasis. M. D....Northwestern on trail of gene mutations that trigger sex reversal
... The mice progeny from the sex determination/sex reversal study will be made available to the scientific com...hese genes can presumably cause not only overt sex reversal XY females and XX males but also much milder manifestations of sex reversal disorder," Weiss said....Report urges Congress to increase medical research
...cent increase an amount that represents a serious reversal of fortune for medical research critical to the health and well-being of aging Americans," according to the report. This budget proposal comes just one year after the historic bipartisan effort to double the budget of the NIH. The Task Force report...Study suggests bipolar disorder may cause progressive brain damage
...wth, or neurogenesis, can occur, offering hope for reversal of damage. NAA measurements may also help us to understand how medications work in bipolar disorder. "Lithium has been around for a long time and nobody really knows how it works," Deicken said. However, he points out that long-term lithium treatmen...Good news on cancer for most EU countries but tobacco still a big problem
...cause for concern. Professor Boyle concluded: "The reversal of a continually increasing trend has been a success that has been associated with the activities of the programme. Its major achievement has been the emphasis on prevention and the increased awareness of the importance of this aspect in wide-ranging...Fetal surgery for spina bifida shows early benefits in leg function, fewer shunts
...a shunt to divert excess fluid from the brain, the reversal of a potentially devastating neurologic condition ...ure delivery. Of the remaining 47 infants, all had reversal of the hindbrain herniation, and 20 infants (43 percent) required a shunt compared to an 85 percent...Experimental drugs reduce neuron death in rats following insulin shock
...that did not receive PARP inhibitors following the reversal of coma, about 70 percent of cells in two regions ... immediately received the inhibitors following the reversal of coma, brain cell death was reduced by about 85 percent in one of these regions, and 35 percent in...Trials on hormone therapy and hypertension treatment change practice, medication usage of patients
... use from 1996 through 1999. "There was a moderate reversal in these trends following ALLHAT early termination and subsequent publications in early 2000," they write. "Between 1999 and 2002, new annual alpha-blocker prescription orders declined by 26 percent (from 5.15 million to 3.79 million), dispensed pres...Scientists grow neurons using nanostructures
...th, a promising development that could lead to the reversal of paralysis due to spinal cord injury. "We have created new materials that because of their chemical structure interact with cells of the central nervous system in ways that may help prevent the formation of the scar that is often linked to paralys...Moderate-fat diet is kinder to heart than low-fat diet, study by UB researcher shows
..., during the weight-maintenance phase, there was a reversal of the weight-loss induced drop in triglycerides and a reduction in HDL cholesterol compared to baseline in the low-fat group, but not in the moderate-fat group. "These results show that although weight loss does improve the lipid profile, a moderat...Prevalence of HIV among childbearing women has declined in New York
...es vertical transmission, resulting in a potential reversal of the observed downward trends in maternal HIV prevalence among childbearing women. Thus, the continued decrease in prevalence is even more remarkable because of this possibility that more women who know their HIV status may be electing to have chi...Synbiotic modulation of gut flora improves minimal hepatic encephalopathy in cirrhotic patients
...ynbiotic preparation or fermentable fiber showed a reversal of MHE, compared to a 13 percent reversal rate in the placebo group. Furthermore, patients in both treatment groups had a lower fecal pH at da...Guideline evaluates treatment of infantile spasms
...atrin offer the best chance of seizure control and reversal of the developmental regression that is often associated with this severe form of epilepsy." There is insufficient evidence to conclude that successful treatment of infantile spasms improves the long-term prognosis, according to the guideline. "There...Imaging studies clarify brain changes associated with language deficits in autism
... showed that most right-handed autistic boys had a reversal of this pattern, with the larger area on the right...side. Other researchers have reported similar reversal of the normal brain asymmetry in people with SLI, a condition of delayed language development withou...MRI shows brain changes underlying language deficits in autism
...nt -- both the autism and SLI groups -- showed the reversal of language area asymmetry, while both groups of language normal boys -- both the autism and control language normal groups -- had typical asymmetry." Furthermore, Harris noted, the degree of language impairment was related to the degree of Broca's a...Scientists reveal significant behavioral impacts of early life stress, study therapies
... adoptive mothers in the second month of life, the reversal took place, but at a slower pace. Monkeys paired in the third month of life did not exhibit a reversal of these atypical behaviors. The researchers believe this study shows a small but distinct window o...PITT, OHSU: When early life stress occurs determines its impact later
... adoptive mothers in the second month of life, the reversal took place, but at a slower pace. Monkeys paired in the third month of life did not exhibit a reversal of these atypical behaviors. The researchers believe this research shows a small but distinct windo...Jefferson scientists use gene therapy to rescue failing hearts in animals
...actually reversed. This is a remarkable rescue and reversal of cardiac dysfunction, with obvious clinical implications for future heart failure therapy." Close to 5 million Americans have heart failure and more than 400,000 new cases are being diagnosed each year. While the overall death toll from heart disea...Researchers identify the link between heart failure and weight loss
...ngineered to overproduce IGF-1 there is a complete reversal of angiotensin-induced weight loss. The authors provide strong evidence that the signaling pathway known as the Akt/mTOR/p70S6 kinase pathway is involved in this ability of IGF-1 to prevent muscle loss. These findings have broad relevance to the even...