Tacrolimus Stops Rejection Of Kidney Transplants
... drug tacrolimus (also known as FK506) can halt or reverse unmanageable rejection of transplanted kidneys in three out of four cases says a report from 13 of the country's leading transplant centers. Despite tremendous progress in regulating the immune system, stubborn or "refractory" rejection-an unrelentin...NIAID Stops AIDS Study Prematurely Because Drug 'Cocktail' Boosts Survival
...as ZDV and 3TC work by inhibiting an enzyme called reverse transcriptase. That enzyme enables the virus' genetic material, or RNA, to convert human genetic material known as DNA into more virus. The Food and Drug Administration approved use of the combined ZDV and 3TC in November 1995, in part because of a ......y becombination therapy since no single agent will reverse all of the abnormalitiesseen in our diabetic patients," Dr. Shulman explains. "Therefore, it isessential that we understand the mechanism by which these novel oral medicationslower patients' blood glucose. We then will be able to combine them in ar...ONYX Pharmaceuticals Reports Phase II Clinical Trial Results At ASCO Meeting
...e cancer, and on developing innovativetherapies to reverse the effects of the mutation or to kill thecancer cell. Onyx pursues a strategy of establishing corporate partnershipsthat provide complementary skills in chemistry, drugdevelopment, and marketing and sales. This press release contains certain forwa...Metrifonate, A New Alzheimer Drug, Helps Behavior Problems
...isease." He stresses that the drugs do not reverse Alzheimer symptoms or keeppatients stable forever. "If people are cognitively impaired to the point whereit no longer is safe for them to drive a car, for example, taking an AChEinhibitor won't restore them to a point where they will be able to resum...World's First Producer To Repair Brain Damage From Stroke
... this trial. "Use of manufactured cells to reverse brain damage removes the ethicalconcerns many people have about the use of fetal tissue," said Peter Jannetta,M.D., chairman emeritus of the UPMC Department of Neurological Surgery andWalter Dandy Professor of Neurological Surgery, University of Pitt......nsible for relaying messagesbetween neurons -- can reverse symptoms of a rat model of schizophrenia withoutapparent side effects, according to a Yale University School of Medicine study. The research, published in the Aug. 28 issue of the journal Science,suggests a possible new class of medications t...... of efavirenz, a new non-nucleoside reverse transcriptase inhibitor (NNRTI) tha...inhibitor nelfinavir and nucleoside reverse transcriptase inhibitors (NRTIs). As a safeguard, this highly intensive study was ...Steroids May Reverse Loss Of Substance Tied To Nervous-System Diseases
...nois scientists suggest they also could be used to reverse a lossof myelin -- a major problem in multiple sclerosis and other demyelinatingdiseases and injuries associated with the central and peripheral nervoussystems. Treatment of MS already includes the use of steroids, because they relieveinflammation a...Candles with lead wicks emit lead into the air
...heenvironment and medical treatment does not fully reverse the health effects, theoptimal strategy for minimizing the risk involves the reduction or eliminationof exposure in various forms. This study shows that there are still otherimportant domestic sources of lead exposure that have escaped public scruti...UNC Researchers Find Drug-Resistant HIV In Semen
...s for HIV. Six had received previoustreatment with reverse transcriptase (RT) drugs, which are designed to block HIVfrom delivering its DNA into the cell. All subjects were identified withdetectable levels of the AIDS virus both in their blood and semen when the studybegan. At the beginning of the s...UNC-CH Studies Show Medicine Can Reverse Osteoporosis From Transplants, Cystic Fibrosis
...nd the United States,have explored ways to stop or reverse post-transplant osteoporosis but withoutmuch success," Aris said. "We think this is the first evidence not only that youcan treat osteoporosis after lung transplantation for cystic fibrosis, but alsoit's the first evidence of a good drug response to ...UCSF Study Finds DHEA Benefits Cardiovascular Function
...imal study, conducted on pigs, shows that DHEA can reverse theeffects of Endothelin-1, or ET-1, a peptide that is elevated in most heartdiseases, including heart attacks and high blood pressure. A balance between ET-1 and nitric oxide is essential for maintainingvascular tone, which is necessary for...Differences In Brain Function Found For Attention Deficit Disorder
...whennot. The healthy boys, in contrast, showed the reverse - less activity in thoseareas when taking the drug than when not. "From past work with adults and children, some of which required injectingradioactive material, a consensus developed that it is the frontal striatalcircuitry of the brain that is wha......drugs such as AZT. Once HIV invades a human cell, reverse transcriptase (RT), one of three enzymes used by HIV, reads the retrovirus's genetic material, RNA, and synthesizes DNA, which codes for viral proteins that commandeer the infected cell's protein-making machinery. In an article published in the Nove...U-M Researcher Addresses Changes In The Heart As It Ages
...prevent all of the age-related changes,but they do reverse or prevent some of the changes that occur, such as...uyt said. "Regular exercise can delay or partially reverse some of these changes in theheart and improve the reserve capacity while reducing the risk of heart ...New approach supercharges immunotherapy
...n immune response have not been ableeffectively to reverse the immune tolerance that develops between a patient's Tcells and their cancer." But by growing billions of a patient's T cells in the laboratory, away fromtumor cells and under constant co-stimulation with CD3 and CD28, Liebowitz'steam has been able...Discovery May Boost Effectiveness Of Chemotherapy
...patients and mayopen the door to new strategies to reverse resistance to cancer-fighting drugs. "We have found a cancer resistance protein that rapidly pumps outchemotherapy from a certain line of breast cancer cells," says L. Austin Doyle,M.D., associate professor of medicine at the University of ......xposing the neuron to MAG or myelin, youcompletely reverse the inhibition of axonal regrowth," explains Filbi...lying MAG antibodies to the affected cells had the reverse effect and actually fostered nerve regeneration. Marie T. Filbin, a resident of Manhattan's Upper We...... detection andchemoprevention - ways to chemically reverse precancerous lesions and blockcancer development - for those at high risk." The scientists found that men had a significantly higher incidence ofprecancerous lesions in the large central airways than women. They also foundthat fewer women than men ha...