Duke Study Suggests New Class Of Drugs Could Bypass Leptin Loop
...rsity Medical Center show thatthe protein leptin's role in weight loss has as much to do with burning stored fat reservesas it does with signaling the brain that the stomach is full -- a discovery that could leadto a new class of drugs that bypass the leptin brain circuit and target the fat cell itself. ...Shark-Liver Substance May Slow Growth Of Brain Tumors
...ine, named for the shark genus Squalus, may find a role with chemotherapy, radiation and surgery in treating brain cancer and other solid tumors in people, say scientists from Hopkins and Magainin Pharmaceuticals, which processes squalamine and funded the studies. Hopkins scientists added squalamine, a ho...Testosterone May Affect Learning Skills; May Be Put In Tablet Form
...may provide additional insight into testosterone's role in the brain. "This is an interesting, early findi...ists also are investigating whether estrogen has a role in brain function, including preventing or delaying the onset of Alzheimer's disease. Other authors ...New Colorectal Cancer Treatment Available
...uished history, the Center has played a leadership role in defining the standard of care for patients with cancer. In 1995, Memorial Sloan-Kettering was named the nation's best cancer center for the third consecutive year by U.S. News & World Report....Emory Doctors Discuss "Killing Heat" In This Week's NEJM
...ice providers. Letter carriers play an important role by hand-delivering the mail to elderly customers on their route." Dr. Kellermann is director of the Division of Emergency Medicine, Department of Surgery, Emory University School of Medicine, and director of the Center for Injury Control and Pre...Alzheimer's disease center seeks patients for new drug studies
...esearchers have made progress in understanding the role played by genes. The new generation of medications target various sections of the brain that degenerate during the course of the disease. Alzheimer's disease affects approximately 4 million Americans. The UT Southwestern clinic currently sees about ...What Makes Tics Tick? Clues Found In Tourette Twins' Caudates
...r. "While we know that genetics plays an important role in transmission of Tourette Syndrome, the fact that identical twins show differences in symptom severity suggests that environmental influences modify the clinical expression of the disorder," he explained. "We studied identical twins discordant for...Childhood Sex Abuse Impacts Adult Relationships
...use on attachment in later life and to examine the role of childhood attachment relationships in moderating the effects of sexual abuse. "We looked at attachment because attachment theory provides a model of individual development in the context of family relationships, whereby the child's sense of self ...ACTG Protocol 185 Enrollment Halted
... pregnancy, it will not be possible to address the role of HIVIG in reducing perinatal transmission in a timely fashion. However, in areas of the world in which HIVIG may be a more practical option, it is possible that this question could be addressed. It is still unknown whether passive immunization by...Duke Study Uses Tiny Temperature Changes To Probe Water-Exclusion At Protein Binding Sites
...t" to show that water plays anunexpectedly crucial role in determining whether a drug will bind with aprot...e atoms are arranged in a molecule plays a crucial role in determininghow important water reorganization is to ligand binding. If removing water from ...Mother's Milk: Nutrition And Nurture For Infants -- And The Best Defense Against Disease
...pregnancy, and lactation, also plays a significant role in stimulatingimmune-system cells in the infant. A...the infant. Another molecule with an antibacterial role islactoferrin, a protein that acts by binding iron in different situations. Insome circumstances, la...'Bathtub' Equation Aids Diabetes Research
...se processes." Her initial research focused on the role of insulin, which allows sugar inthe bloodstream to enter into the body's tissue. She went on to study thecells that make insulin. Applying her engineering perspective, she developeda mathematical model that could describe how the cells were formed a...NIH Honors Emory Researcher With Merit Award For Work On Renin-Angiotensin System
...icfashion? and (2) Is there any real physiological role of testis ACE in malereproductive biology? He answ...kout mice to understand more about the physiologic role of ACE inreproduction and blood pressure; and the biochemistry of testis ACE expressionas a model of...Affordable, Hand-Held Biosensor For Diagnostics
...to its complementary strand, suggestinga potential role for a variety of genetic studies and tests, including DNAfingerprinting for clinical and forensic applications. Another biosensor provedsensitive to the binding of certain antibodies, manufactured by the body'simmune system, to small amounts of their...Women Say Overwhelming Yes To Ultrasound In New Study
... health care dollars, we are planning to study the role of education in changing patient's beliefs about screening prenatal ultrasound." This study was conducted by researchers from the departments of radiology, obstetrics and gynecology , and CHOICES (Centers for Health Outcomes, Innovations and ...Transcranial Magnetic Stimulation Enhances Short-Term Brain Plasticity
...nction that they see afterinjury play a beneficial role by helping the brain to compensate, or if they areharmful or simply irrelevant, says Dr. Cohen. They also need to understand moreabout how plasticity occurs so they can design and test new strategies forcontrolling it. The NINDS, one of the ..."Powerful New Tool" For AIDS Is Reported In Science
...e College, PA., which is playing a crucial ongoing role in developing the required instrumentation. Initial in vivo results of T cell proliferation rates in AIDS patients using isotope mass spectrometric techniques were announced Feb. 3, 1998 at the 5th Conference on Retroviruses and Opportunistic Infecti...Tighter Chemical Binding = Better Meds
...nson's and Alzheimer's diseases. FKBP also playsa role in transplant rejection, making it a doubly important protein tocontrol. Jorgensen and his co-workers have performed calculations on FKBPwith a series of potential drugs, analyzing why they vary in bindingstrengths and suggesting ways to improve the...National Health Study Launched On The Internet
... 56,000 runners. Thesurvey has played a prominent role in the ongoing national debate overrecommendations on the desirable levels of physical activity. Williams alsolaunched a companion study, the National Walkers' Health Study, which currentlyincludes 5,000 walkers. Williams says the Internet could pro...Clinical Pharmacists Improve Outcomes Of Heart Failure Patients
...are taking their medications can play an important role inreducing rehospitalizations, Gattis said. Joining Gattis and O'Connor in the study, which was funded by the DukeClinical Research Institute and Duke's Division of Cardiology, were Dr. VicHasselblad, Dr. David Whellan and Rhonda Larsen....