Reviparin effective in reducing risk of death after heart attack
...clinical practice without a definitive test of its safety and effectiveness. The conceptual basis for its use is sound, and its rationale has been delineated in a variety of publications cited by the CREATE investigators. Unfortunately, regardless of its scientific rationale and the positive results of smal...More studies on risks and benefits of COX-2 inhibitors published in Archives of Internal Medicine
...prove drugs rapidly, we should not expect that all safety issues will be understood prior to a drug's approv...s brought to the forefront concerns about the drug safety system that have been raised before. These issues must be addressed now if we are to restore the pub...Study estimates number of excess cases of coronary heart disease caused by Vioxx
...sed attention will now focus on the cardiovascular safety of other COX-2 inhibitors (coxibs). Professor Webb concludes: "It now falls to the manufacturers, under the careful review of the regulatory authorities, to provide the evidence that this class of drugs is safe, if necessary including studies that d...Study shows drugs such as Vioxx and Celebrex were widely over-used long before recent problems
...m older, inexpensive drugs with better established safety and efficacy to newer, costly drugs with no real history," said study author G. Caleb Alexander, M.D., M.S., instructor of medicine and a member of the MacLean Center for Clinical Medical Ethics at the University of Chicago. "We pursued our analysi...Study shows strengths, gaps in quality of care for kids in California's public mental health clinics
...hild and Adolescent Psychiatry, the study examines safety and appropriateness of care for attention deficit ... psychoactive medication did not document adequate safety monitoring through vital signs or laboratory studies. "Findings from this study raise serious questi...Two minutes of magnetic stimulation can change your brain for an hour
...ntional TMS. Initial tests performed to assess the safety of TMS showed that there were no long-lasting or side effects from these stimulations. Professor Rothwell says: "Now that we have improved the technique, we can use it to explore whether stimulation of damaged areas in stroke patients' brains can hel...Collaborative care, training boosts adolescent depression treatment in primary care clinics
...Association. After recent controversies about the safety and effectiveness of adolescent depression treatme...ctive treatments. "Recent controversies about the safety and benefits of antidepressant medications in youth have led to concerns regarding how to best treat...Editorial urges 'black-box' warning for Bextra and Celebrex
...n November. "These data raise questions about the safety of the drug in other patients who have heart conditions, but who aren't having surgery," said Furberg. "In the absence of evidence of safety, it is prudent to avoid the use of Bextra altogether or use it only as a drug of last resort," says the edito...PENN study emphasizes need for national guidelines for assisted reproductive technology programs
...value being that they ensure a prospective child's safety and welfare and not risk the welfare of the prospective mother." The study also found that there was a significant variation across programs in their reported likelihood of turning away candidates. The researchers found, for instance, that when pro...New insight into link between homocysteine and stroke
...arge randomised trials to examine the efficacy and safety of this approach are still awaited. Aroon Hingorani (University College London, UK) and colleagues used an approach known as Mendelian randomisation to overcome some of the problems of confounding factors seen in observational studies. The investigat...Complementary & alternative medicine use
...are, and that we need to do more research on their safety and effectiveness - just as we would with any other therapeutic options," concludes Eisenberg. Over the five-year period between the two most recent surveys, the total number of Americans using any CAM therapy remained fairly stable at 72 million. Ho...Complementary and alternative therapies and conventional medical therapies
... patients should have sufficient information about safety and efficacy to take advantage of all useful thera...evidence that the therapy is effective or may have safety issues; whether there is a plausible biological mechanism by which the therapy might work or the lik...Rotary blood pump shows promise for pediatric patients
...recovery. The article relays how the efficacy and safety of VADs were demonstrated in numerous trials along the way. After 50 years of use, VADs are still considered to be in their infancy, but today, the technology has contributed to prolonging support for patients, and has helped to maintain healthy, fu...First new treatment for alcoholism in ten years, now available Campral(R) (acamprosate calcium)
...gency's review of short and long-term efficacy and safety data from double-blind, placebo-controlled trials. In three of the trials, which lasted from 90 days to 360 days, Campral plus psychosocial therapy proved superior to placebo plus psychosocial therapy in maintaining abstinence, as indicated by a grea...New treatment guidelines for pregnant women with asthma
...asthma based on a systematic review of data on the safety of asthma medications during pregnancy. An executi...he guidelines note that there are more data on the safety of budesonide use during pregnancy than on other inhaled corticosteroids; however, there are no data...Care of rural stroke patients improves with telephone support
...pital to receive tPA, in part due to liability and safety concerns. For this study, patients were treated at small rural hospitals with telephone support from the stroke center, and then transported to the stroke center for care. The study compared those who were treated in the rural hospitals and transp...Gene vaccine protects mice against development of Her2/neu breast cancer
...ieves that the vaccine will address two additional safety considerations "because it is built of RNA that cannot insert itself into the genome, and the possibility of autoimmunity to it appears to be low, because normal cells express very small amounts of the HER2/neu growth protein." Contributors to the st...FDA approves Pfizer's Lyrica for the treatment of the two most common forms of neuropathic pain
...tained in studies of up to 12-weeks duration. The safety of Lyrica was established in over 9,000 patients. In all clinical trials, adverse events were mild to moderate. The most common side effects associated with Lyrica compared with placebo included dizziness, somnolence, dry mouth, peripheral edema, blu...Most alcohol-related plane crashes occur at night and in worsening weather conditions
..., and on a minimum of 10 percent of employees with safety responsibilities, including pilots. While the number of alcohol-related infractions is low, statistics compiled by the Federal Aviation Administration indicate that about one person in 200 of the tested flight crew had BACs above the legal limit. I...Study determines commonly used contrast agent safe for 'universal use' in CT
...avenously or intraarterially, but up until now its safety has only been proven for selected procedures such ...agents and to have a benchmark study regarding the safety of the agent in a large group of patients," said Koenraad J. Mortel, MD, lead author of the paper. "...