Duke Study Suggests New Class Of Drugs Could Bypass Leptin Loop
...chairman of the department of psychiatry, began to search for the pathwayby which leptin signals the body to burn fat. Using genetically obese micethat lacked the leptin protein, researchers administered leptin to one groupand a saline placebo to the other group. Because the genetically obese miceproduced n...What Makes Tics Tick? Clues Found In Tourette Twins' Caudates
...aspects of Tourette Syndrome had led researchersto search for clues in the putamen, according to Weinberger. Subtle changes in receptor availability in one small area appear to explain rather large differences in clinical presentation, say the researchers. Functional brain imaging studies of OCD (obses...Substance from Grapefruit Juice May Make Medications Safer
... This finding is important because it narrows the search for the substance in grapefruit juice that is responsible for its effects on drug metabolism. Isolating this substance could enable manufacturers to produce safer and more effective medications. One of the most interesting findings from the Univers......he amount of timerequire for a search, because the search is roughly de-coupled from thesize of the database...for example.Among the types of data the system can search are acoustical signal waveforms, one-dimensional signals and acoustics, sonar, ultrasound andradar s...Cancer Protection Compound Abundant In Broccoli Sprouts
...of issued and pending patents. A systematic search for dietary sources of compounds that increaseresistance tocancer-causing agents led the Hopkins group to focus on naturally occurringcompounds inedible plants that mobilize Phase 2 detoxification enzymes. These enzymesneutralize highlyreactive, dan...Intervention can help reduce risky sexual behavior, according to results published in Science
... Science. The section also includesarticles on the search for an HIV vaccine; the interplay between HIV proteinsand normal cellular activities; and the virus's wily strategies for evading theimmune system. In addition, there are commentaries on a variety of topics,including: the challenge of testing HIV pat...DFG To Fund Four New Research Units
...s at Dresden Technical University will embark on a search for better implants in the research unit "Studies of, and interactions at, biologised bone-implant interfaces". They will strive to find materials for implants which bond more firmly to human bone than has been possible so far. The researchers will t......ly at the problemsseemingly tied to fen-phen. In a search of literature that is readily availableto physicians, pharmacists and students, Maher quickly discovered While the labels on fenfluramines and other serotonin uptake-blockersclearly warn against combining these drugs with MAO inhibitors, no ...Some CFS Patients Benefit From Low-Dose Steroid, But Side Effects Too Risky
...lief, specific treatments for CFS donot exist, the search for them frustrated by the unknown etiology of theillness. Several years ago, Dr. Straus and his colleagues found that CFS patients hadslightly lower levels of circulating cortisol, the major glucose-regulatingstress hormone, than did healthy individ......e how combinatorial chemistry also is speeding the search fornovel catalysts, specialty chemicals and a wide range of new materials. Someday, combinatorial processes may even help scientists grapple with suchcomplex problems as speech recognition, says honorary conference chairperson H.Mario Geysen, a Disti...Fetal Cell Therapy Benefits Some Parkinson's Patients
...y. These results raise important questions in the search for improvedtreatments for Parkinson's disease. The study, led by Curt Freed, M.D., at the University of Colorado in Denver, andStanley Fahn, M.D., at Columbia-Presbyterian Medical Center in New York,included 40 patients with advanced Parkinson's dis......changes in spinemorphology, but it was the literal search for the needle in the haystack sincethe researchers did not precisely know where the spine changes would occur. Themicro-superfusion technique then was crucial to overcome this problem. Itallowed to reduce synaptic transmission and therefore the pote...Clogged Neck Artery May Warn Of Heart Attack As Well As Stroke
...nvasive ultrasound tests of the carotidarteries to search both the left and right sides, and branches, forobstructions. Researchers found that severe atherosclerosis in the carotid arteries wasrelated to severe coronary heart disease. Conversely, normal carotid arteriesindicated the person had no severe c...Cure For Abnormal Heart Rhythm Available To More People
...rson's blood vessel and guide it into the heart to search forthe tissue housing the abnormal rhythm. Once the abnormal heart tissue isdetected, radiowaves heat and destroy the tissue. "The multielectrode basket catheter adds a new dimension to mapping theelectrical signals of the heart for better t...Mayo Clinic Study Finds Costs For Cancer Clinical Trials Comparable To Costs For Standard Treatment
...f life forpatients, and faster advancements in the search for new treatments for allcancers." The study, to be published in the May 19, 1999, edition of Journal of theNational Cancer Institute, finds that the costs of treating patients in clinicaltrials were modestly higher -- less than 10 percent higher --...Advance reported in search for skin cancer treatment
In a search for skin cancer treatments, chemists at the Universityof Notre Dame have constructed a computer model of the chemical structure of anenzyme that many organisms use to repair DNA damaged by ultraviolet light. Their findings are reported in the Jun...AAPS Symposium to present latest developments in Cheminformatics
...logies puts cheminformatics at the forefrontof the search for new drugs," said Peter M. Smith, Ph.D., chair of thesymposium's planning committee. "All discovery scientists must use a variety ofthese technologies to manage and communicate their research results, and in manycases, these can replace tradition...New protocol to develop compound to treat disorders of the central nervous system is more efficient
...ompany that applies leading-edge technology in its search forinnovative new drugs that meet unmet medical needs of people worldwide,"said August M. Watanabe, M.D., executive vice president, science and technologyat Eli Lilly and Company. "It naturally follows that we should dedicate similarresources to......commercialization effortsare underway, including a search for potential marketing and manufacturinglicensees.......s plan for setting up Clinical GeneticsNetworks to search for the genetic basis of common diseases. "I have known and collaborated with Jonathan Haines for two decades and askedhim to be a consultant when we set up the Genetics Directorate," said Dr. AllenD. Roses, vice president and world-wide director for...