Tag: "selective" at medical news

Depression may explain higher risk of heart attack associated with antidepressants

... drugs. And patients prescribed the newer class of selective serotonin reuptake inhibitors (SSRIs) were over twice as likely to have a heart attack within the next seven days. But the increased risks of a heart attack were much lower among patients who took antidepressants for longer than a month. These risks ...

Celecoxib safe for short-term use in patients with cirrhosis

Short-term use of selective COX-2 inhibitors may be safe for patients with cir... studies in experimental cirrhosis have shown that selective COX-2 inhibitors, such as celecoxib, do not affect renal function. By contrast, nonsteroidal anti-in...

Study finds new designer drug is potent treatment for chronic myelogenous leukemia

...ancer Institute has shown that a potent and highly selective therapy for chronic myelogenous leukemia (CML) may ultimately be more effective than Gleevec, the current standard of care. The researchers report in the February issue of Cancer Cell that the new compound, AMN107, is about 20 times more potent than ...

Promise of 'bladder pacemaker' for people with spinal cord injury

...edical Company, which has exclusive license to the selective stimulation patent relevant to this research. NDI Medical is also the U.S. distributor of the Vocare device....

Smoking causes cognitive impairment in adolescents

...and smokers have comparable focused, sustained and selective attention, and improved working memory, suggesting...d were significantly more impaired during tests of selective and divided attention, she said. All of the adolescent smokers also showed further disruption of wor...

Penn study shows how next-generation diabetic drugs could work more selectively

...s already underway to design drugs called SPPARMs, selective PPAR modulators, which would specifically target g...h the same fat-cell target as TZDs, but which is a selective regulator of gene expression in such a way that will increase the benefit-to-risk ratio of the diabe...

More studies on risks and benefits of COX-2 inhibitors published in Archives of Internal Medicine

...hage Patients taking warfarin at the same time as selective COX-2 inhibitors or nonselective NSAIDs have an in...rly heighted in warfarin users treated with either selective COX-2 inhibitors or nonselective NSAIDs. physicians and pharmacists who care for elderly patients ...

Study estimates number of excess cases of coronary heart disease caused by Vioxx

... to a class of cyclo-oxygenase 2 (COX-2) inhibitor selective non-steroidal anti-inflammatory drugs (NSAIDs), which are prescribed for the treatment of arthritis. Vioxx was withdrawn from the pharmaceutical market at the end of September 2004 after use of the drug was linked to heart problems. David J Graham (...

Routine use of nose-to-stomach tube slows recovery from abdominal surgery

...ended goals and so should be abandoned in favor of selective use of the nasogastric tube," the authors conclude. The review appears in the January issue of The Cochrane Library, a publication of The Cochrane Collaboration, an international organization that evaluates medical research. Systematic reviews draw...

Invasive procedures do not necessarily improve survival for heart patients

...d on bmj.com today. The researchers recommend more selective use of procedures, and argue against early routine...ry syndrome is harmful but that a more restrictive selective use of invasive procedures is at least as effective as a more liberal routine use, say the authors. ...

Common antidepressants lower effects of tamoxifen in many women

... confirmed data from an earlier study showing that selective serotonin reuptake inhibitor antidepressants may hinder the effectiveness of tamoxifen, a drug commonly administered to breast cancer patients. The study also reports that researchers now have pinpointed genetic types that are linked with this effect...

News tips from the Journal of Neuroscience

...d body position. Evoked potential mapping revealed selective activation at the temporoparietal junction. It seems that out of the body is not necessarily out of the brain....

2001-2002 survey finds that many recover from alcoholism

... state the authors. However, they acknowledge, the selective survival of less chronic alcoholics (the fact that persons who recover from alcohol dependence may be more likely to have survived to the survey date) may have inflated the recovery estimate. When the authors compared their results with findings from...

Penn researchers add more evidence to demonstrate role of COX inhibitors in heart-disease risk

... Therapeutics at Penn, raised the possibility that selective COX-2 inhibitors might predispose patients otherwise at risk for an increased incidence of heart attack and stroke. This proposal was based initially on his studies of how celecoxib (Celebrex) and rofeocoxib (Vioxx) worked in human volunteers. The fi...

Study identifies predictors of HIV drug resistance in patients beginning triple therapy

...that they are taking enough medication to create a selective pressure," Dr. Harrigan said. "Which means that resistant virus mutations still have an opportunity to replicate instead of reducing the viral load to levels so low it can't replicate at all." "The good news is that although they require a very high ...

News tips from the Journal of Neuroscience

...erential actions of serotonin modulation (e.g., by selective serotonin reuptake inhibitors) on frontal lobe functions. 2. Blocking A-Stimulated Inflammation with Statins Andrew Cordle and Gary Landreth This week, Cordle and Landreth examine a novel action of statins beyond their well known ability to lower c...

New guidelines conclude all aerosol therapy devices equally effective

...of obstructive respiratory disease by allowing the selective delivery of optimal concentrations of drugs to the airway without creating the undesirable side effects that might result from systemic administration," said Myron J. Zitt, MD, President of the American College of Allergy, Asthma & Immunology. "Nonet...

New protein discovered by Hebrew University researchers

...us enhance the effectiveness of chemotherapy. This selective penetration is based on the fact that the blood vessels which feed tumors are considerably more porous than those reaching healthy cells. Therefore, the units of SP-1 carrying the drug would invade only the tumor-feeding blood vessels and not normal...

Residual tumor cells are a barrier to targeted cancer therapeutics

.... "Any way you look at it, when physicians apply a selective pressure to a tumor by blocking an oncogenic pathway, cells escape," says Chodosh. "They find a back door and progress to a more aggressive state that becomes independent of that pathway." Chodosh concludes that the type of genetically engineered mou...

Social development program in childhood aids in positive functioning as an adult

...d alcohol. Studies have shown the effectiveness of selective interventions in children from families in poverty in encouraging positive adolescent and adult outcomes. J. David Hawkins, Ph.D., from the Social Development Research Group, School of Social Work, University of Washington, Seattle, and colleagues...

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