St. John's wort ineffective for depression
...ressant sertraline (trade name Zoloft), which is a selective serotonin reuptake inhibitor (SSRI), as a "control" to measure the sensitivity of the study for detecting antidepressant effects of hypericum. SSRIs such as sertraline are a class of drug found to be effective in treating several forms of depression....The Lancet Oncology and The Lancet Infectious Diseases
...e evolution of tamoxifen therapy in breast cancer: selective oestrogen-receptor modulators and downregulators Use of minimally invasive oesophagectomy for cancer of the oesophagus Clinical management of dyspnoea Mediastinal (thymic) large B-cell lymphoma: where do we stand? Culprit and victim - DNA topois...Hormone therapy for breast cancer - the treatments of the future
... are proving even more effective than tamoxifen, a selective oestrogen modulator or SERM. Although tamoxifen acts largely as an antioestrogen in breast cancers it actually exhibits pronounced oestrogenic activity when oestrogen levels are very low," said Professor Dowsett. He said there were data from laborato...Raloxifene after tamoxifen not beneficial
...ors caused by low-dose estrogen. Tamoxifen is a selective estrogen receptor modulator (SERM) that reduces breast cancer recurrence in women with early-stage breast cancer. However, studies show that the benefits of tamoxifen diminish after five years and that additional therapy with tamoxifen may significan...Raloxifene following tamoxifen may offer no more reduction in breast cancer risk
...ional Cancer Institute . Adjuvant therapy with the selective estrogen receptor modulator tamoxifen helps some women with early-stage breast cancer reduce their risk of recurrence. But some studies have suggested this benefit levels off after 5 years, and further treatment with tamoxifen not only doesn't help, ...UCSD researchers find raloxifene is not associated with early cardiovascular harm
...said Dr. Barrett-Connor. "We know that raloxifenea selective estrogen receptor modulator, or SERMacts through estrogen receptors in a more selective fashion than estrogen therapy. But we wanted to know if there might be a similar increase in early c...Stroke news tips for Friday, Feb. 8, 2002
...placebo-controlled, 26-week treatment study of the selective serotonin re-uptake inhibitor sertraline. Depression improved in stroke survivors treated with sertraline and placebo. Researchers will report detailed results of sertralines effects on neurological recovery, quality of life, healthcare costs and o...A peptide whose absence leads to narcolepsy also might play role in pain sensation
...t studies showed that narcolepsy was caused by the selective neurodegeneration of the hypocretin system. Prior to that finding, narcolepsy was sometimes blamed on laziness or indistinct mental problems. Van den Pol said the new findings show that in addition to hypocretins role in enhancing arousal, the neurot...MetaPhore Pharmaceuticals initiates Phase I clinical trial of enzyme mimetic compound for oncology
...een able to reproduce that benefit in a stable and selective drug form, said Denis Forster, Chief Operating Officer of MetaPhore. These novel therapeutics have tremendous potential, based on the growing body of research linking free-radical mediated damage with a wide range of acute and chronic disease state...Smokers more likely to experience impotence, Wake Forest study shows
...t most of these earlier studies looked at a highly selective group of patients going to urology or cardiology clinics, he said. "This is the first study that looked at a primary care population and is more reflective of the general population." Spangler said smoking has "both acute and chronic effects on e...Highest known catalytic rate for superoxide dismutation achieved
...o reproduce that beneficial effect in a stable and selective drug form, said Dennis Riley, MetaPhores Senior Vice President of Research & Development. MetaPhores SOD enzyme mimetics are well suited for use as drugs because they have a low molecular weight, are highly stable and do not appear to elicit an immu...Animal studies indicate new approach for treating end-stage skin and kidney cancers
...o reproduce that beneficial effect in a stable and selective drug form, said Dennis Riley, MetaPhores Senior Vice President of Research & Development. MetaPhores synthetic SOD enzyme is well suited for use as a drug because it has a low molecular weight, is highly stable and does not appear to elicit an immune...Beyond Viagra: other phosphodiesterase inhibitors are candidates for potential therapies
...een for the drug companies to find agents that are selective for specific phosphodiesterases so that they can t...the most widely prescribed drugs. Viagra is a very selective drug. It acts on one specific PDE found in the penis. In the presence of nitric oxide, a signaling m...... have been searching for estrogen alternatives, or selective estrogen-receptor modifiers (SERMs), that interact with the cell receptor for estrogen and confer estrogens beneficial properties, yet curtail its tumor-promoting role. The MORE trial showed that raloxifene blocks the estrogen receptors in estrogen-r...Mouse provides clues about chronic pain
... for the development of drugs that would be highly selective for persistent pain. They would allow people to ignore chronic pain while leaving the rest of the pain system intact."...... identifying the Nogo protein as one important and selective blocker of axon regeneration in the brain after central nervous system injury. Axons are the telephone lines of the nervous system, carrying a nerve impulse to a target cell. "Once we had Nogo in hand, we needed to know: How does it function? How do...Getting older and feeling weaker?
...ide maximum strength or force, and we experience a selective loss of these fibers as we age. So, Nussbaum explains, we are left with more of the fatigue-resistant fibers. "If young and older workers are performing the same tasks, the older ones are typically working at a higher proportion of their capacit...Estrogen has antitumor activity in hormone therapy-resistant breast tumors
...he drugs tamoxifen and raloxifene. Tamoxifen is a selective estrogen receptor modulator (SERM) used to treat estrogen receptor-positive breast cancers and prevent recurrence of the disease. However, tamoxifen often loses effectiveness over time and can subsequently stimulate breast cancer growth. New endocrin...New discovery may revolutionize treatment for pain related to surgery, illness and injury
...t particular segments of the body, this allows the selective delivery of drugs to relevant parts of the nervous system involved in pain sensation and other disease processes. The researchers created a complex made up of an axonal transport facilitator (ATF) attached to a linker molecule bearing up to a hundr...Brain imaging technology can reveal what a person is thinking about
...revious studies have shown that brain areas can be selective for processing a particular type of visual information. In the cortical brain regions associated with mental processing, the 'fusiform' face area responds strongly to faces while the 'parahippocampal' place area responds strongly to indoor and outdoo...