Unexpected target may unlock the door to fighting sepsis
...e University of Michigan Health System, found that septic rats injected withan immunoglobulin (IgG) antibody against C5a had powerful protection againstsepsis. In the group of rats treated with the antibody against C5a, more thanhalf survived. By contrast, in a second group treated with standardimmunoglobul......ausing a fulminant blood infection, bringing about septic shock and shutting down the body's organs. This can occur very rapidly," says Dr. Arditi. Although the bacterium that causes meningococcal infections -- Neisseria meningitidis - is easily passed through direct contact activities such as coughing, sne......tal blood pressure drop that typically accompanies septic shock if new treatments are developed based on an ...roxide anions produced in large quantities during septic shock deactivate dopamine, norepinephrine and epinephrine destroying their biological activity and o...NIH awards grant to MetaPhore Pharmaceuticals to study novel pain treatments
...d often fatal blood pressure drop that accompanies septic shock. The company's first drug candidate is targeted at cancer, where it is proceeding toward an Investigational New Drug (IND) submission to the FDA by year-end. The second drug candidate, for acute and chronic pain, is expected to move into cli...FDA awards grant to metaphore pharmaceuticals to study septic shock in humans
... perplexing blood pressure drop that occurs during septic shock and leads to death in up to 50 percent of ca...at oxygen free radicals, produced in excess during septic shock particularly superoxide anions play in deactivating the bodys vascular regulation system. ...Highest known catalytic rate for superoxide dismutation achieved
...effects in animal models of reperfusion injury and septic shock at dosage levels one hundred times less than those required using the original SOD enzyme mimetic. The lower dosage plus retention of the originals high degree of stability makes the improved SOD mimetic an even more attractive candidate for...Sepsis on the increase in U.S., according to Emory University and CDC study
...th an identifiable infection, when patients become septic their immune systems are intensely activated, setting off a cascade of events that may result in uncontrolled inflammation throughout the body. Sepsis also activates the coagulation system by promoting thrombosis and inhibiting fibrinolysis, which i...Bleach-producing enzyme found to modulate blood vessel dilation during inflammation
...be useful for treating systemic hypotension during septic shock. Alternatively, drugs aimed at blocking the activity of myeloperoxidase may be useful for treating chronic vascular diseases, such as atherosclerosis, which are commonly characterized by a deficit in the vasodilatory substance nitric oxide and...Sepsis vaccine proves protective in preliminary studies at The Scripps Research Institute
...A Rapid and Deadly Disease Sepsis, also known as septic shock and systemic inflammatory response syndrome,...ody, from the bones to the brain, and death due to septic shock can occur in a matter of hours. According to the National Institutes of Health, two percent o...JCI Table of Contents, November 14, 2003
...of TNF-alpha, such as would occur in patients with septic conditions or related infectious disorders, actually inhibited platelet aggregation and thrombus formation in vivo. Platelets from TNF-alphatreated mice had decreased fibrinogen binding and P-selectin expression and reduced platelet aggregation in re...Changes needed to reduce migrant farm worker exposure to pesticides
...ng systems, ill-fitting windows and doors, and old septic systems," said Arcury. "Many of these houses are surrounded by agricultural fields." In North Carolina, more than 100,000 mostly Mexican natives work on farms. They are either permanent residents or migrate to the state. On these farms, pesticides ar...Study shows that diabetes increases risk of blood poisoning
...y bloodstream infection, and may lead to fever and septic shock, a potentially fatal drop in blood pressure. Diabetic people are more vulnerable to bacterial blood infections called bacteremia, particularly if they develop other bacterial infections, such as urinary tract infections (UTIs). Danish researche...American Thoracic Society Journal news tips for February 2005 (first issue)
.... In the control group, one patient admitted with septic shock died on Study Day 3, and nine patients developed delayed septic shock that was complicated by acute respiratory distress syndrome in four. One additional control p...