Mouse model reveals potential way to reduce cardiac deaths in kidney patients
...s during bone reconstruction. With those processes shut down, scientists theorized, the bloodstream levels of minerals increase, raising pressure to deposit them elsewhere. Hruska and his colleagues first showed that injection of BMP-7, previously shown to stop the bone disorder, also stopped vascular ...Drug that hinders blood vessel growth under study in ovarian cancer
...gulate them and prevent growth. If that process is shut down, the tumor should not grow or spread." A6 has been shown to inhibit cancer metastasis in animal studies and showed "encouraging responses" in patients with advanced ovarian cancer in Phase 1 clinical trials, according to Virgil Thompson, pr...CK2 protein sustains colon cancer cells by sabotaging ability to commit suicide
...y bit of genetic material specifically designed to shut down a particular gene--in this case, the gene for the alpha proteins that make up part of CK2. Again, CK2 activity was lost, the cancer cells were sensitized to TRAIL, and the cells committed suicide. The researchers also showed that the ability o...UCSD-Salk team show protein's gene-silencing role in development of nervous system
...ere they shouldn't be. When these phosphatases are shut off in the nervous system, neuronal stem cells can develop into specialized neurons. The researchers determined that SCPs are a component of a previously identified master gene complex called REST/NRSF, which is known to control neuronal genes. In t...Mayo Clinic discovers potential marker for aggressive kidney cancer
...ncers by protecting their immune system from being shut down. About Kidney Cancer There are different kinds of kidney cancers. Renal cell carcinoma accounts for approximately 85 percent of all kidney cancers. In the United States, an estimated 35,000 patients will be diagnosed with kidney cancer a...Study may lead to new means of increasing effectiveness of existing cancer treatments
...rthermore, they discovered that the pathway can be shut off at the cell surface by compounds that block the receptor. Once turned off, such cancer cells become more sensitive to agents that induce cell death. While it was previously known that the Wnt pathway is involved in almost all cases of colon cance...UCLA brain researchers uncover new clues to SIDS
...ildren do not struggle to breathe when their lungs shut down -- even after turning blue from lack of air. IMPACT: The findings suggest that the irregular brain mechanisms provoking CCHS may also underlie sudden infant death syndrome (SIDS). Children afflicted by the two conditions share many of the...Gene-silencing technique offers new way to fight drug-resistant leukemia
...of Lyn kinase protein, the Lyn gene is effectively shut down, or "silenced." With Lyn out of the picture, the cancer cell dies. "We hope that this therapy will be able to enter the clinic rapidly, perhaps even within the next couple of years," say Gewirtz. "The basic methodologies are in place but an siRN...New hope for ALS seen with genetic techniques, growth factors
... PhD, used a technology called RNA interference to shut off the toxic SOD1 mutant gene that causes the motor neuron disorder in ALS mice models. RNA, or ribonucleic acid, is a molecular intermediate between DNA and protein. Each DNA gene holds the code for production of a particular protein. That code is...Two novel agents work synergistically to treat lung cancer in animal experiment
...so have the independent ability to enter cells and shut down the growth cycle and induce the cell to self destruct," says Lee. While previous work at M. D. Anderson has shown that IGFBP-3 successfully stops the growth of head and neck cancers when tested in animal models, other research has demonstr...Sealing corneal incisions with a drop of chemistry, BU researchers develop gel for cataract surgery
... incision to seal itself or stitching the incision shut using nylon sutures. Each closing method has its drawbacks. Self-sealing, in which the open wound closes gradually over time, carries the risk of infection as well as leakage of intraocular fluid. Suturing likewise can carry the risk of infection...$5 million grant awarded to U.VA health system targets leukemia drug development, creates new jobs
...hibit these proteins, we hope that leukemia can be shut down. Since the molecules are selective, the side effects of treatment and the long-term prognosis for leukemia patients should be significantly better than they are today." Bushweller also expects the grant to create about eight new research j...Stanford scientists help bring study of smallpox virus into 'molecular age'
...itical molecules that control immune response were shut down in smallpox infection but not Ebola, indicating that smallpox may be producing inhibitors of these molecules. Of particular interest in future studies, said Relman, is to identify the events that happen soon after infection - the "early mo...New technology blocks gene to increase immune response against deadly brain tumor cells
...ogy that uses short strands of genetic material to shut down a specific gene, researchers have regulated immune system proteins to boost production of cells that seek and destroy cancer cells. This approach may improve the effectiveness of vaccines in the treatment of tumors, including malignant brain tum...Novel vitamin discovery offers clues for cancer chemotherapy and lipid disorders
...e enzyme, every known NAD biosynthetic pathway was shut down, so in theory, the cells should die; no vitamins or supplements were known to keep the cells alive. However, the researchers discovered that another NAD precursor, nicotinamide riboside, thought to be a vitamin form of NAD only in certain bacte...Cancer gene therapy news backgrounder: New ideas fuel next generation gene therapy research
...it on. After each incident, the federal government shut down related gene therapy clinical trials for a period of time and has increased oversight of all clinical trials.While there have been no similar serious reactions to adenovirus-based cancer gene therapies, the major hurdle any such therapy faces is...Iressa news backgrounder: Testing of smart drug expands at M. D. Anderson Cancer Center
...r gefitinib) that worked on the inside of cells to shut down the EGF receptor signaling pathway. ZD1839 was developed in the labs of AstraZeneca pharmaceuticals after researching many new chemical entities that had a high affinity to the EGF receptor site. Baslega, currently at a university hospita...Researchers identify leukemia-linked pathway targeted by a new kinase inhibitor
...mall molecule kinase inhibitors," medicine slammed shut a door used by cancer. Researchers at The Jackson Laboratory just found another door that kinase inhibitors may close to cancer. The gene BCR-ABL1 causes two types of leukemia: chronic myelogeneous leukemia (CML) and B-cell acute lymphoblastic leukem...'Switched-off' genes put first chink in colon cell's anti-tumor armor
... Our key finding is that the cell also may need to shut off SFRP genes to become cancerous," says Baylin. When Baylin's team put SFRPs back into colon cancer cells with inactivated SFRP genes and mutations in the WNT pathway, the cells stopped growing uncontrollably and died. The research team also f...Cancer markers news backgrounder: Future of cancer diagnosis, treatment lies in tumor 'barcode'
...es, such as the drug Gleevec, which is designed to shut down the crucial genetic/protein pathway involved in chronic myeloid leukemia and another rare cancer of the gastrointestinal tract, called gastrointestinal stromal tumor. Herceptin treats metastatic breast cancer that is driven by a gene known as HE...