Hunger hormone may be key in weight loss
...n the operation, 95 percent of the stomach is sewn shut so it cant receive food. As a result, the patient feels full much sooner and eats less at each meal. However the new study suggests another mechanism may be at work. Cummings and colleagues believe the cells in the stomach that produce ghrelin become...Researchers identify a key 'brake' of the immune response
... from the body itself, explains Dr. Suciu-Foca. To shut down the immune response, the body presses its "foot" harder on the brake pedal to boost ILT3 and ILT4 activity in the dendritic cells. To enhance the immune response, the body lowers the ILT3 and ILT4 activity. In the study, the investigators showed...University of Rochester awarded patent for class of drugs known as cox-2 inhibitors
...e production of the new protein could be virtually shut down by administering an anti-inflammatory steroid. This finding led Young to conclude that aspirin and other NSAIDs were effective at controlling inflammation because they were acting on the new protein - which was later named cox-2 - and that the ...Genetic test for melanoma developed at UCSF
...mosome 7. Cancer cells that are missing DNA have shut down certain genes on that chromosome and, similarly, extra DNA suggests that the melanoma has generated extra copies of some genes on that chromosome. By testing suspicious looking skin cells for these abnormalities, dermatologists can be muc...New understanding of a key control mechanism in the brain
... filter inhibitory messages, enabling I-neurons to shut down the activity in neighbors as required. These synapses act as fast-switching "if-then" filtering gates that allow inhibition to be applied only at the exact millisecond and to the right degree. Each I-neuron establishes complex if-then gates onto...NICHD funded researchers discover gene for Rett syndrome
...e permanently switched off. The Xchromosomes are shut down in an apparently random pattern. In about ha...sence of this genetic switch,certain genes fail to shut down, and excessive amounts of otherwise beneficialproteins are made. The cells that have an active...UI researchers discover that aggressive cancer cells may make their own blood vessels
...n though more complexly orchestrated processes are shut off bydrugs or by the tumor itself as it grows," Maniotis said. "In addition, becausethese vascular channels can be constructed in the laboratory with human cells,new forms of cancer therapy could be developed that would specifically interferewith th...UI study finds types of decision-making deficiencies depend on area of brain damage
...ck to another any time they wished. The experiment shut offautomatically after 100 card selections; however, the researchers did not tellthe subjects in advance how many cards they would be able to pick. Using a mouse, the subjects could click on a card in any of the four decks. Thecomputer tracked the se...Researchers discover the driving force behind cancer cells in Hodgkin's disease
...s to multiply. We are nowworking to find a way to shut down that engine. These findings have hugeclinical potential," said Dr. Tak W. Mak, senior scientist at the Ontario CancerInstitute, director of the Amgen Research Institute and professor of MedicalBiophysics and Immunology at the University of Toro...Novel Biological Interaction Found To Explain Blood Vessel Growth To Tumors
...atin's "key" fit intothe cellular "lock" that then shut down vessel growth. Since plasminogen is known to bind to a protein called annexin II on endothelialcells, they expected to find that angiostatin bound to same site.After several years of gathering material and analyzing data, Moser found adifferent...UCSF Study In Rats Suggests Synthetic Drug Mimicking Marijuana Might Be Used To Treat Pain
...drug reduced pain. However, after the researchers shut down the RVM, ratsthat were given WIN55,212-2 no l...of motor coordination. However, after the RVN was shut down, a conditionthat reversed the analgesic effects, rats continued to show a loss of motorcoordina...Transcranial Magnetic Stimulation Enhances Short-Term Brain Plasticity
...rwell used a simple tourniquet around the elbow to shut offthe blood supply to the forearm, blocking nerve signals to the brain andtemporarily mimicking what occurs after amputation. The loss of normal signalscaused the brain to reorganize. When the researchers applied TMS to the plasticcortex, or the p...Discovery Hints At Multitude Of New Targets For Drugs
...not be triggered by a 'round' receptor, andthey'll shut off." For example, he said, the same estrogen receptorinfluences a variety of processes throughout the body, including developmentof the female reproductive system, muscle and bone. "We believe that nature has managed to produce a wide array of effe...... can become super-heated if the windows are nailed shut to thwart burglars. Some residents will not leave their home unguarded. Others are simply too proud or too fearful to seek refuge in a 'public' shelter. "(Public) money spent on fans (for poor citizens) should be redirected elsewhere" since "...fa...