Tag: "signaling" at medical news
Chemical decoy shows promise for slowing Alzheimer's by acting as decoy
... to be involved in many cell activities, including signaling
and differentiation. Sialic acids are particularly abundant on the surfaces of brain cells but also found in lower amounts in the rest of the body. The researchers theorized that creating a polymer that acts like the surface of a brain cell, with its...
Mechanism of RNA recoding: New twists in brain protein production
...teins responsible for fast chemical and electrical signaling
in animal nervous systems are the main targets of this process. In a prior study, Reenan's group identified species-specific patterns of RNA recoding on such targets, but didn't explain how they were determined or how they may have evolved. His new s...
News tips from the 2005, 54th Annual Scientific Sessions of the American College of Cardiology
...ge County Convention Center.) Disrupted fat cell signaling
in obese mice has been linked to increased cell de...obese mice and normal mice showed that when leptin signaling
was disrupted, the hearts became enlarged and apoptosis increased by more than 10 times what occurs ...
Researchers discover link between insulin and Alzheimer's
...ing a gene abnormality in rats that blocks insulin signaling
in the brain, researchers found that insulin and IGF I and II are all expressed in neurons in several regions in the brain. Additionally, researchers determined that a drop in insulin production in the brain contributes to the degeneration of brain ...
Potential treatment for Fragile X Syndrome demonstrated in fruit fly model
...ork is that maintaining proper regulation of mGluR signaling
is a conserved function of the dFMR1 and FMRP proteins and that loss of dfmr1 function in flies leads to at least a subset of the cognitive and behavioral defects observed in the fly model," says Jongens. "These results provide a potential route by w...
US cancer researchers launch first American-Israeli cancer conference
...address research advances in cancer genetics; cell signaling
at the DNA/RNA level; immune system therapies; targeted treatments; novel approaches to breast cancer and solid tumors; and stem cell transplantation in the treatment of leukemia. A mini-symposium will address environmental causes of cancer. Israeli ...
CK2 protein sustains colon cancer cells by sabotaging ability to commit suicide
...ect within a structure called DISC (death-inducing signaling
complex). The DISC is a large jumble of proteins that interact with each other after TRAIL binds to the outer cell membrane. After DISC forms, an enzyme called caspase-8 triggers the cascade of biochemical events outside DISC that eventually leads to...
Researchers model brain's electrical storm during a seizure
...There are several possible causes for the abnormal signaling
in epilepsy, including illness, injury, abnormal brain development and an imbalance of the chemical neurotransmitters needed to convey messages in the brain. Some seizures begin in a very specific area of the brain called the "seizure focus" before s...
UCLA neuroscientists pinpoint new function for mirror neurons
...ping of a tea cup within each of the two contexts, signaling
intent either to drink or to clean. Actions embedded in context, compared with the other two conditions, increased blood flow in the posterior part of the brain's inferior frontal gyrus, known to be important for grasping control, and in the adjacent...
News tips from the Journal of Neuroscience
...l transducer and activator of transcription (STAT) signaling
downstream of the cytokines. The JAK2STAT3 pathway appears to be growth-promoting after a peripheral nerve injury....
COX-2 product offers good and bad news in 'test tube' strokes
... part by a huge release of glutamate, an important signaling
molecule in the brain. In their experiments with brain cells and brain tissue from rats, the Hopkins researchers used glutamate to simulate the aftereffects of a stroke. After strokes and other injuries to the brain, levels of glutamate rise, trigger...
New way to block pox shows promise in lab study
...ws that it is possible to block temporarily a cell signaling
pathway and thereby inhibit activity of a virus," ...Dr. Reinherz explains. "The advantage of targeting signaling
pathways is that cells--and the structures that send and receive signals--are far less likely to mut...
News Tips from the Journal of Neuroscience
... , Sairanen et al. assess BDNF- and trkB- mediated signaling
in mice chronically injected with antidepressants. 2. Crossing Bridges to Spinal Cord Regeneration Karim Fouad, Lisa Schnell, Mary B. Bunge, Martin E. Schwab, Thomas Liebscher, and Damien D. Pearse Unfortunately, there seem to be plenty of obstacle...
Drug treatment promising for halting Huntington's-related nerve death
...e Huntington's disease mutation, defective calcium signaling
in the cell, and subsequent degeneration of medium...tion of mutant huntingtin protein with the calcium signaling
proteins in striatal neurons," he said. "We have a nice model system set up where we can easily look...
Rice scientist recognized as pioneer in tissue engineering
...-based polymeric carriers for targeted delivery of signaling
molecules including peptides, proteins, and plasmid DNA. A pioneer in the field of tissue engineering, Mikos is a founding editor of the journal Tissue Engineering and member of the editorial boards of the journals Biomaterials, Advanced Drug Deliver...
JCI table of contents, January 20 2005
... The study demonstrates that IL-6 signaling
controls the balance between the production of pro...nflammation. As such, drugs designed to block IL-6 signaling
may represent a promising approach to the treatment of the inflammation associated with allergic ast...
Researchers identify the link between heart failure and weight loss
... to demonstrate that angiotensin II inhibits IGF-1 signaling
in skeletal muscle and that this effect is causall...loss. The authors provide strong evidence that the signaling
pathway known as the Akt/mTOR/p70S6 kinase pathway is involved in this ability of IGF-1 to prevent m...
USC/Norris oncologists test new front-line therapy for pancreatic cancer
.... BAY 43-9006's first strategy is to disrupt cell signaling
in what scientists call the Ras gene pathway. The ...reatic cancers. By throwing a roadblock in the Ras signaling
pathway, BAY 43-9006 attempts to keep cancer cells from proliferating. "This compound also has anti-...
USC researchers find evidence that progesterone signaling influences ovarian cancer risk
...gesterone receptor, which is the first step in the signaling
pathway by which the progesterone hormone does its...nt evidence that direct modulation of progesterone signaling
influences cancer risk," the researchers note. "Understanding how this variation influences risk of ...
Four teams awarded inaugural translational cancer research grants
...lecular genetics, regulatory proteins and cellular signaling
can be applied to new diagnostic technologies and targeted treatments to help the cancer patients. The V Foundation-AACR Grants in Translational Cancer Research offer awards to top doctors and scientists at National Cancer Institute (NCI)-designated ...
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