Beijing conference to address lung cancer crisis in China
...e, PhD, will discuss recent findings about the Wnt signaling pathway. Wnt signaling likely plays an important role in lung cancer, they said, and modulating this signaling pathway coul...Prostate cancer program at UCLAs Jonsson Cancer Center designated a site of research excellence
...ttack against the disease. Were covering the major signaling pathways that we think are involved in prostate cancer, he said. UCLA has invested in basic science programs that are bearing fruit now and have clinical implications. This is an opportunity to put these ideas into clinical trials. Dr. Judith C. Gass...$2 million federal grant to study cancer drug action
...nal Institutes of Health to model key colon cancer signaling pathways and to test the predictions of the company's cell computer simulations. The GNS ATP award was one of 40, totaling $101.6 million, granted by the program in the 2002 annual competition. The awards will be matched by industry cost-sharing of ...Carcinogen in cigarettes causes mutation linked to lung cancer
... clinically significant differences in biochemical signaling pathways that can potentially be therapeutically targeted."...Other highlights in the October 2 issue of JNCI
...l When treated with inhibitors that block certain signaling components, breast cancer cells can revert back to... breast cancer cell lines with inhibitors of three signaling components: 1 integrin, mitogen-activated protein kinase (MAPK), and/or phosphatidylinositol 3-kinas...Patient race is a determinant in receiving coronary angiography referral
...cedure, researchers question if these patients are signaling to physicians, in direct or indirect ways, that they would not be willing to submit to an invasive procedure such as coronary angiography or if physicians may simply assume this fact without communication from the patient. Previous research showed th...Study finds new target for development of anti-cancer drugs
...n causes traffic jams to occur among intracellular signaling proteins. Such a high frequency of km23 alterations in human tumors suggests that the alterations are important for tumor development and growth. Finding drugs to override these defects should prevent the tumor from growing and spreading further. We ...Molecular mechanism underlaying anthrax infection described by UCSD School Of Medicine researchers
...t defense against pathogens, and also disables the signaling mechanism triggering immune activation. This allo...prevent secretion of chemokines and cytokines, the signaling agents that alert the immune system to the presence of an invading pathogen. According to Karin, the...FINAL ALERT: RPB Science Writers Seminar in Eye Research to be held in Washington, DC Sept. 22-25
...with the retinal "chips" of today, but by chemical signaling via light-activated release of appropriate neurotransmitters at precisely the right sites. *Studies of newly approved 30-day-wear, "sleep-in" contact lenses that point to a 10- to 40-fold decrease in infection risk over conventional lenses. *A "unif...Potent experimental drug shown to slow the growth of breast and prostate cancer tumors in mice
...nly targeted HER-2/neu, but that it disrupted cell signaling among the entire HER family of proteins," said Dr....an important role in tumor growth, it's the growth signaling process that we ultimately want to block," commented Dr. Agus. Earlier studies by Dr. Agus' research...Common treatment for cancer pain stimulates breast tumor growth in mice
...tivate the mitogen-activated protein kinase (MAPK) signaling pathway in human endothelial cells (cells that form blood vessels). MAPK plays a key role in promoting endothelial cell multiplication and angiogenesis (formation of new blood vessels). Angiogenesis can cause tumor growth by providing nutrients to gr...Quick blood test for heart failure proves successful in multinational trial
...eased by the heart ventricles when pressure rises, signaling a failing heart. The BNP test received approval by the Food and Drug Administration (FDA) in 2000, and is currently the only blood test cleared by the FDA as an aid in diagnosing congestive heart failure. It proved effective in an earlier pilot st...Genetic variant reduces immune response, yet protects against atherosclerosis
...lar polymorphism appears to attenuate the receptor signaling ability and to diminish the inflammatory response. Our results suggest that the diminished inflammatory response is responsible for a decreased risk of atherosclerosis," said Duke's David Schwartz, M.D., principal investigator for the study, the resu...Gene expression profiles predict survival of lymphoma patients after chemotherpy
...at NCI and other institutions. Blocking the NF-kB signaling pathway with PS-341 will allow DLBCL tumor cells to die more readily, which researchers hope will improve patient survival. This trial will enroll DLBCL patients who have relapsed after standard chemotherapy. Gene expression profiles of the patient...Scientists identify brain mechanism that boosts response to alcohol
...ens may become hypersensitive to alcohol because a signaling molecule links two chemical pathways: one involvin...synergy" between the two chemical pathways via the signaling molecule, the researchers discovered, so this molecule may make a promising target for drugs to trea...Researchers shed light on mechanisms of voluntary alcohol consumption
...ing to one of its receptors (D2 subtype) generates signaling proteins known as beta gamma dimers that, through ...enosine type 2, or A2), ethanol generates the same signaling protein and subsequent activation of PKA. Further, dopamine and ethanol applied together to the cell...Protein essential for switching on T-cell response
...ing triggers a number of chemical reactions-called signaling pathways--within the T-cell, enabling it to react to the disease-causing substance. Two key signaling pathways that lead to activation in all cells are the calcium pathway and the Ras pathway. The LAT ...Other highlights in the June 5 issue of JNCI
...revents Local But Not Distant Metastases Blocking signaling by the vascular endothelial growth factor receptor...ignaling. The authors found that blocking VEGFR-3 signaling suppressed primary tumor and regional lymph node metastasis but had no effect on distant lung metast...UNC studies add new dimension to 'lock-and-key' theory of drug action
... the key to the different effects relates to other signaling proteins, called G proteins, that are required for the receptors to function. The different G proteins may be the doors in which the lock, or receptor, is installed, awaiting the key, or drug, Mailman said. What makes this research noteworthy is that...Calcium-dependent potassium channels as target to increase drug delivery to brain tumors
...dilation of vessels. Bypassing the normal cellular signaling mechanisms, they were able to directly activate the potassium channels. This enabled them to increase blood-brain tumor barrier permeability and significantly increase the amount of a tracer going into tumors. Not only was the BTB effectively opened,...