Duke Study Suggests New Class Of Drugs Could Bypass Leptin Loop
...ry, began to search for the pathwayby which leptin signals the body to burn fat. Using genetically obese micethat lacked the leptin protein, researchers administered leptin to one groupand a saline placebo to the other group. Because the genetically obese miceproduced no natural leptin, it was easier to trac...Digital Speech Analysis Tests Sobriety
...speech. She then spent several years analyzing the signals produced bythe sounds, looking specifically at the glottal excitation waveform. During speech production, air passes from the lungs through theglottis, an opening in the vocal cords, then is shaped into sounds byparts of the vocal tract, such as the...Fertilization Protein Structure To AID in Leukemia Treatment
...ell membrane, providing a means for it to transmit signals to the inside of white blood cells. "By modifying the chemical bonds in molecules outside the cell, the size and shape of the protein cavity may be changed, and this effect can be transmitted across the cell membrane by the attached tail," explain...KUMC Researchers Announce Breakthrough Method For Predicting Epileptic Seizures
...lgorithm measures brain activity and separates the signals into seizure and non-seizure components. This crea... seizure components reach a certain critical level signals that a seizure is about to occur. Epilepsy is caused by factors such as head trauma, brain t......h are acoustical signal waveforms, one-dimensional signals and acoustics, sonar, ultrasound andradar signatures. "Law enforcement may be able to use it to find marijuana productionfields in aerial photography, and oil companies could use it to domineral analyses of spectral images," Barnes said. "It could h...New Approach To Multidrug Resistance
...o damage than genesinduced in response to external signals -- such as hormone fluctuations or anincursion of foreign chemicals. Because the gene for P-glycoprotein isinducible, activated by cues from its environment, investigators were interestedin how it would be affected by cancer chemotherapy drugs. The...NIH Honors Emory Researcher With Merit Award For Work On Renin-Angiotensin System
...e Jak2 kinase, which in turn initiates acascade of signals often referred to as the Jak-STAT pathway. Through thiscascading pathway, messages are sent from the cell surface to the cell nucleus.Although receptors for several other kinds of cell mediators are known to usethis pathway, the AT1 receptor is a mem...Jefferson Researcher Finds New Digital X-Ray Technology May Cut Costs And Improve Patient Care
...nergy is captured and converted into electronic signals that form a precise digital image on a video screen, said Dr. Shaber. These images can be duplicated and transmitted electronically with no loss of quality, he said. Furthermore, there is software available that would allow a radiolo...Transcranial Magnetic Stimulation Enhances Short-Term Brain Plasticity
...offthe blood supply to the forearm, blocking nerve signals to the brain andtemporarily mimicking what occurs after amputation. The loss of normal signalscaused the brain to reorganize. When the researchers applied TMS to the plasticcortex, or the part of the brain that was undergoing reorganization because...Research Trial To Test New Drug For Diabetic Neuropathy
... Gaithersburg, MD. " Nerves conduct electrical signals to the arms and legs. When this doesn't work properly, it is called neuropathy. This drug shows great promise to improve nerve conduction for patients with diabetic neuropathy," says Zachary Simmons, M.D., associate professor of medicine at Penn S...New Math, High-Tech Imaging Solving Old Riddle: How Does The Brain Operate When We Think?
...newexactly howto interpret changes in the magnetic signals caused by changes in brainactivity," says Peter C.... in thatarea of the body. Inturn, this alters MRI signals released by molecules in there. The researchers demonstrated the accuracy of their math by com......ility of serotonin required to transmit electrical signals in nervepathways affecting mood. The new findings suggest that drugs affecting specific signaling pathways in thebrain--pathways affected by serotonin in the case of paroxetine--can lead tochanges in particular personality characteristics. Personal......e needed to transmit moderate or more intense pain signals in a variety ofpainful conditions. Although the mutant and normal mice needed the same amountof morphine to relieve mild pain, the mutant mice, which lacked the tachykinins,needed less morphine to experience pain relief under more intense paincondit...Radio Frequencies Used To Kill Inoperable Liver Tumors At Penn's Cancer Center
By transforming radio signals into a surgical laser,surgeons at the University of Pennsylvania Cancer Center are using high-energy radio frequency sound waves to destroy inoperable primary and metastatic liver tumors. The powerful procedure -- called radio frequency ablation -- i...Is Ritalin As Effective--And As Harmless--As It Could Be?
...he brains ofbaboons and humans. (Radiotracers emit signals as they decay that can becollected by a PET scan to generate images.) The study showed that the d-threoenantiomer bound precisely to the dopamine targets in the brain, while thebinding of l-threo was mostly non-specific. What's more, Ding says, the l...Adding Progestins May Negate Heart Protection From Estrogen Replacement Therapy
...ase, althoughother research has documented that it signals the first stages ofatherosclerosis," he says. In atherosclerosis, blood vessels narrow due to blockages fromcholesterol or blood clots, setting the stage for a heart attack or stroke. Previous studies have found that women taking est...Most People Cant Identify Stroke Symptoms
...stroke treatment, people must learn howto read the signals that are telling them to seek medical help so that they cantake immediate action," said John R. Marler, M.D., of the NINDS Division ofStroke, Trauma, and Neurodegenerative Disorders. "The best way for patients to receive the most effective stroke tre...Researchers Identify Candidate Immunosuppressant With Fewer Side Effects
...eurin, a key molecule in the pathway thattransmits signals from the T cell receptor to the nucleus. The key differencebetween how the peptide and the drugs cyclosporin A and FK506 work is the regionon calcineurin where each of these agents bind. Cyclosporin A and FK506 blockthe active site of calcineurin and...Neurotransmitter-Induced Electrical Activity Identified As Key Regulator Of Synaptogenesis
...It remained enigmatic, however, which signals instruct a cytoplasmic protein about the presence or absence of an apposing glycinergic nerve terminal. By paralyzing cultured spinal neurons with tetrodotoxin Kirsch and Betz now found that electrical activity is required f...Effective Obesity Treatment Likely To Require Targeting Of Multiple Weight Control Systems
...ience. The authors focus on the molecular signals that control food intake.The research review shows...central nervoussystem participate in responding to signals informing the brain about the fatcontent of the body. "While the notion of a single 'magic b...