Researchers find better way to predict childhood brain tumor outcomes
...medulloblastoma, but because it suggests that such signatures are likely to be detectable for other cancers as well." Golub is an assistant professor of Pediatrics at Harvard Medical School and holds joint appointments at Childrens Hospital Boston, Dana-Farber Cancer Institute and the Whitehead Institute. "The...Detecting breast cancer spread by white light - groundbreaking technology
... few days. A computer was used to learn the cancer signatures from most of these comparisons chosen at random, and then the accuracy of the technique was tested on the rest of the samples. "The number of patients is still relatively low, but the preliminary results indicate that the same diagnostic information ...Research helps explain why perception of pleasure decreases with chronic cocaine use
...hresholds appears to be one of the neurobiological signatures of the transition to addiction. WHAT IT MEANS: Based on this study, it appears that promising new therapies for addiction may be based on treatments that mute the desire to escalate cocaine intake by blocking the elevation of brain reward thresholds...Study suggests bipolar disorder may cause progressive brain damage
...ture and function. Researchers determined chemical signatures of different brain structures in these two groups using proton magnetic resonance spectroscopy. One finding focused on the level of an amino acid called N-acetylaspartate, or NAA, in the hippocampus, which is made up of a right and left half and is p...Testing may one day pinpoint which early-stage cancer patients are at risk for relapse
...ies will be able to identify molecular and genetic signatures in cancers that will allow physicians to know which diseases are more aggressive and have acquired metatastic capabilities, and which tumors have not. This information will result in better clinical decisions about what the optimal therapies are for ...Emory School of Medicine receives $16 million NIH grant to lead biodefense consortium
...use genomics and proteomics to study the molecular signatures of vaccine-induced innate and adaptive immune responses, says Rafi Ahmed, PhD, director of the Emory Vaccine Center, a Georgia Research Alliance Eminent Scholar, and principal investigator of the Emory grant. "These molecular 'signatures' will help ...NYU School of Medicine attracts a powerful MRI machine
...renia by their biochemical brain signatures. These signatures could provide early clues to chemical changes in the brain that are occurring due to disease, and potentially offer new treatment options that could modify these alterations. For example, Dr. Grossman's laboratory has identified the signature of a ch...Protein that predicts tamoxifen resistance is identified
...ime of diagnosis to determine what their molecular signatures are and then to select the best therapy aimed at treating the tumor." Other authors on the research team, all from Duke, include Mark Dewhirst, Ph.D., Donald McDonnell, Ph.D., Holly Dressman, M.D., Stacey A. Snyder, and Jeffrey R. Marks, Ph.D....Novel technique may help detect certain head and neck cancers
...iomarkers are molecular or biochemical features or signatures that can indicate disease. Newly developed techno...iling" technology could help them identify protein signatures specific to patients with HNSCC. The researchers screened blood serum samples from 99 patients w...Promising diagnostic test for sleeping sickness
...Mass spectrometry created distinct blood proteomic signatures characteristic of human African trypanosomiasis. The test was shown to have a sensitivity of 100% and a specificity of 986% (ie, importantly, a very low chance of recording 'false-positive' results). Professor Krishna comments: "We report the accur...Chemical brain scans may help reassure brain tumor patients
...-voxel scans are created by averaging the chemical signatures from a broader area, which means that tumor tissue and nearby dying tissue might be considered together. Multi-voxel scanning also allows radiologists to look at the tissue in a variety of locations inside and outside the original tumor area -- possi...NCI scientists create model that predicts follicular lymphoma survival
... tumors have an important impact on survival--both signatures came from such immune cells. The progression rate ...," added Staudt. The fact that the most predictive signatures came from immune cells suggests an important interplay between the host immune system and malignant ...Fred Hutchinson receives $9.7 million to lead early detection consortium
...atterns of protein fragments. These unique protein signatures are then sorted with an artificial-intelligence computer program that identifies the discrepancies in protein patterns between people with and without cancer. Proteins linked to cancer may then serve as biomarkers to detect early disease and predict ...... Dr Jenssen comments: "Faced with alternative gene signatures for very similar prediction problems, we are left with the obvious questions of which to trust and why they differ. Although Wang and colleagues present the largest study of this type of data, it may still be too small to provide a final selection of...