UCSD-Salk team show protein's gene-silencing role in development of nervous system
...uired for maintenance of neural stem cells and for silencing expression of neuronal genes in non-nervous system tissues. Published in the January 28, 2005 issue of the journal Science, the study found that the phosphatases, called small carboxyl-terminal domain phosphatases (SCPs) are expressed in almost all...Study of hypoxia and new gene reveals early-stage action of p53 tumor suppressor gene
...humans that another reason for tumor growth is the silencing of Bnip3L," says El-Deiry. "We think one of the ways that p53 suppresses tumors at their earliest stages is by turning on Bnip3L, and that's new. There is no information at present about how p53 works in the earliest stages of tumor growth, especiall...Molecular tailoring of chemotherapy with novel imaging techniques
...ple, to my knowledge, of the use of inducible gene silencing and non-invasive bioluminescence imaging in a mouse model for cancer." Gene silencing is a technique that allows researchers to control the expression of any gene in a given cell by intr...New hope for ALS seen with genetic techniques, growth factors
SAN DIEGO, Oct. 24 -- Cell transplants, silencing mutant genes, and use of a neuron support factor may represent new ways to treat the fatal brain disorder amyotrophic lateral sclerosis (ALS). Research suggests that implanting cells to support the motor neurons that die off in ALS can help stave of...Duke scientists overcome immune resistance in dendritic cell vaccines for cancer
...rs, and activating them is critical to temporarily silencing regulatory T-cells. "We don't know the specific chain of events that Toll-like receptors activate inside dendritic cells to temporarily silence regulatory T-cells," said Yang. "But we hypothesize that signals enter through the Toll-like receptors and...More than $34 Million in SPORE Grants
...ease in AML, targeting hypermethylation-associated silencing of tumor suppressor genes identify target antigens for both graft versus leukemia effect (GVL) and graft versus host disease (GVHD), ultimately taking specific T cells for GVL and transferring those antigens to leukemia patients validate and imple...Magnetic Hearing Aid Could Open New "Window" For Hearing Impaired
... with feedback and digitally enhances speech while silencing backgroundnoise. Such a device is under development and has been tested in animals withencouraging results. Jonathan Spindel, Ph.D., a biomedical engineer andassistant professor at the University of Virginia's Department ofOtolaryngology, is prepari...