Tag: "situ" at medical news

Risk of cardiac death after radiotherapy for breast cancer has declined, study finds

...ery-good-prognosis invasive tumors and even for in situ breast cancers, for which life expectancy is almost equal to that of the general population and will exceed 20 years in many cases," he writes. "A major advancement in the use of this modality appears to be emerging, but it is still too early to decl...

Non-invasive and invasive breast cancers share the same genetic mutations

...rly stage breast cancer called ductal carcinoma in situ (DCIS). Led by Elizabeth B. Claus, M.D., associate professor in the Department of Epidemiology and Public Health (EPH) at Yale School of Medicine, the Yale team examined genetic and environmental risk factors for the development of DCIS. They genetic...

Mothers' exposure to air pollutants linked to chromosome damage in babies

...omosome painting" technique called fluorescence in situ hybridization, one that enabled researchers to observe the structural changes within the chromosome. Chromosomes are the threadlike packages in the nucleus of the cell that contain the cell's genetic information. "This evidence that air pollutants ca...

Other highlights in the December 15 JNCI

... with tumor receptor status or invasive versus in situ status. Stacey A. Missmer, of Brigham and Women's...vels tended to be most strongly associated with in situ disease. Contact: Amy Smith, Public Affairs, Brigham and Women's Hospital, 617-534-1603, asmith28@p...

USC researchers highlight disparities in cancer rates among racial and ethnic groups in California

...t Latinas, among whom incidence rates declined. In situ breast cancers increased rapidly among all groups, indicating far-reaching effects of mammography screening. Cervical cancer rates declined among all racial and ethnic groups, presumably due to screening, but the decline was small in Korea...

Breast MRI moderately useful for detecting breast cancer, but does not eliminate need for biopsy

...er in 356 of 404 cancer cases (ductal carcinoma in situ [DCIS] or invasive cancer), resulting in a sensitivity of 88.1 percent, and correctly identified as negative for cancer 281 of 417 cases without cancer, resulting in a specificity of 67.7 percent. MRI performance was not significantly affected by mam...

Advances in prevention and treatment research hold promise for 'pipeline'

...plasia associated with HPV, with 55,000 bearing in situ carcinomas. Approximately 15,000 U.S. women have cervical cancer. Globally, HPV-induced cervical cancers are the most common cancers in women in developing countries. One half-million new cases of cervical cancer occur yearly across the globe, leadi...

New study highlights misunderstanding surrounding risks and benefits of tamoxifen

... atypical hyperplasia (AH) or lobular carcinoma in situ (LCIS) derived the greatest benefit e.g., an absolute risk reduction of 86 percent for women with AH in one study. Approximately 2.4 million women are estimated to be eligible to benefit from tamoxifen....

Conservation treatment or mastectomy for DCIS?

...ssuring evidence to women with ductal carcinoma in situ (DCIS) that if they chose to have only the affected area of their breast removed (lumpectomy) rather than the whole breast removed (mastectomy), it would make no difference to their chances of surviving the disease. Even although there was a higher r...

Treatment of ductal carcinoma in situ varies widely in United States

...dy has found that treatment of ductal carcinoma in situ (DCIS), a group of abnormal cells confined to the breast ducts, varies widely in the United States. Treatment ranges from potential overtreatment with aggressive surgical therapy to possible undertreatment by not providing radiation therapy after bre...

Persistently abnormal liver function tests: Marker of occult hepatitis C?

...of the 57 patients. The second method used was in situ hybridization, which demonstrated positive-strand HCV RNA in liver biopsies from the same 57 patients, but in none of those from the controls, and negative-strand HCV RNA in 48 (84%). The investigators noted that the latter finding suggested viral re...

Tumor vaccine to begin clinical trials

... An estimated 267,000 new cases of invasive and in situ breast cancer are expected to occur among women in the United States during 2003, resulting in an estimated 39,800 deaths. "A goal of cancer immunologists is the development of viable cancer vaccines. As we progress into human trial...

Freezing technique kills majority of small malignant breast cancers

...a, and another's biopsy showed ductal carcinoma in situ (DCIS), a non-invasive pre-cancerous condition, in addition to invasive ductal carcinoma. One patient had complete necrosis of the invasive portion of her tumor, but her lumpectomy showed further evidence of nearby DCIS that had not been seen on her ...

High nuclear grade associated with recurrence of in situ breast lesions

Women with ductal carcinoma in situ , a non-invasive form of breast cancer, are more likely to experience a recurrence after treatment if their DCIS is of a high nuclear grade or is detected by palpation during a breast examination, according to a study in the November 19 issue of the ...

Working out may keep breast cells working well

...rcent lower risk of developing breast carcinoma in situ than did inactive women, according to a study in an upcoming issue of the journal Cancer released on the journal's Web site today. Alpa Patel, Ph.D., former doctoral student at the Keck School and now a researcher with the American Cancer Society, is...

Contrast mammography reveals hard-to-find cancers

...nother patient, a case of intraductal carcinoma in situ showed a weakly enhanced duct. The 12 benign cases either showed weak enhancement or none at all. Dr. Lewin said that the new technique is less costly than MRI, which is being used to screen high-risk women. The procedure is similar to conventional ...

North American mammographers prone to more false positives, study finds

...entage of women diagnosed with ductal carcinoma in situ (DCIS), and the percentage of women diagnosed with minimal disease. The percentage of mammograms deemed abnormal by North American programs was 2 to 4 percentage points higher than it was in programs in other countries, even after adjusting for fac...

Mammography frequently detects noninvasive tumors

... will result in a diagnosis of ductal carcinoma in situ (DCIS), and this type of noninvasive tumor makes up roughly 20% of breast cancers detected by screening mammography, according to a study in the October 16 issue of the Journal of the National Cancer Institute . As the use of screening mammography ...

20% of mammogram-detected cancers are in situ lesions of unknown aggressiveness

..., approximately 20 percent are ductal carcinoma in situ (DCIS), a non-invasive tumor contained within the walls of the breast duct, according to a multi-state study led by UCSF researchers. The researchers found that the likelihood of DCIS diagnosis increases with age and, overall, one in every 1300 scree...

National Lung Screening Trial

...he last five years (except some skin cancers or in situ cancers) Are not currently enrolled in any other cancer screening or cancer prevention trial Have not had a CT scan of the chest or lungs within the last 18 months. Additionally, participants can receive referrals to smoking cessation programs if...

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